A5039914669- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Peripheral Artery Disease Management
- Brain Metastases and Treatment
- Cerebrospinal fluid and hydrocephalus
- Radiation Dose and Imaging
- Ear Surgery and Otitis Media
- Cancer, Hypoxia, and Metabolism
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- Vasculitis and related conditions
- Advanced X-ray and CT Imaging
- Neurological Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
University Hospital Augsburg
2016-2025
University of Augsburg
2020-2024
Schön Klinik Vogtareuth
2021-2024
Augsburg University
2012-2023
Université de Reims Champagne-Ardenne
2023
Hôpital Maison Blanche
2023
Centre Hospitalier Universitaire de Reims
2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2023
Berufsverband der Deutschen Dermatologen
2020-2022
University of Freiburg
1994-2018
Background and Purpose— The purpose of this study was to assess the safety performance Wingspan stent system Gateway percutaneous transluminal angioplasty balloon catheter in treatment high-grade, intracranial atherosclerotic lesions patients who had failed medical therapy. Methods— In prospective, multicenter, single-arm study, medically refractory with a modified Rankin score ≤3 recurrent symptoms attributable angiographically demonstrated stenosis ≥50% vessel 2.5 4.5 mm diameter were...
Data from recent reports have indicated that mechanical thrombectomy may potential as a treatment for acute ischemic stroke. The purpose of this study was to assess the safety and performance Penumbra System (PS): novel device designed reduce clot burden in stroke due large-vessel occlusive disease.A prospective, single arm, independently monitored core laboratory adjudicated trial enrolled subjects with an neurologic deficit consistent stroke, presenting within 8 hours symptom onset...
Background: There are limited therapeutic options in cases of failed reperfusion (modified thrombolysis cerebral infarction [mTICI] score < 2b) after stent-retriever and/or aspiration based endovascular treatment (EVT) for acute ischemic stroke. Despite the absence data supporting its use, rescue therapy (balloon angioplasty stent implantation) is often utilized such cases. Studies to large vessel occlusions, while outcomes and complications medium/distal occlusions (MDVOs) have not been...
<h3>BACKGROUND AND PURPOSE:</h3> Several small case series reported a favorable clinical outcome for emergency stent placement in the extracranial internal carotid artery combined with mechanical thrombectomy acute stroke. The rate of postinterventional symptomatic intracranial hemorrhages was to be as high 20%. Therefore, we investigated safety and efficacy this technique large multicentric cohort. <h3>MATERIALS METHODS:</h3> data bases 4 German stroke centers were screened all patients who...
Use of the WEB intra-aneurysmal flow-disruption device in unruptured wide-neck bifurcation aneurysms has proven safety and efficacy. However, ruptured are underrepresented existing studies. This retrospective multicenter study describes use patients with a intracranial aneurysm.Ten centers contributed to this study. Clinical procedural data 47 52 were analyzed retrospectively together follow-up angiographies.There 37 anterior 15 posterior circulation neck size ≥4 mm 49 (94%) aneurysms; 45...
<h3>BACKGROUND AND PURPOSE:</h3> Flow diverters with antithrombotic coatings are increasingly used to improve the safety of flow diverter treatments intracranial aneurysms. This study aimed investigate and short-term efficacy new FRED X diverter. <h3>MATERIALS METHODS:</h3> Medical charts procedural imaging data a consecutive series patients aneurysms who were treated at 9 international neurovascular centers retrospectively analyzed. <h3>RESULTS:</h3> One hundred sixty-one (77.6% women; mean...
We present the results of endovascular photoacoustic recanalization (EPAR) treatment for acute ischemic stroke from Safety and Performance Study at 6 centers in Europe North America. The objectives mechanical thrombolysis are rapid vessel minimal use chemical thrombolysis.This study was a prospective, nonrandomized study. National Institutes Health Stroke Scale (NIHSS) score modified Rankin (mRS) were recorded before treatment. presence assessed by angiography. To measure outcome, follow-up...
The transcription factor family of nuclear I (NFI) proteins is encoded by four closely related genes: Nfia, Nfib, Nfic, and Nfix. A potential role for NFI in regulating developmental processes has been implicated their specific expression pattern during embryonic development analysis NFI-deficient mice. It was shown that loss NFIA results hydrocephalus agenesis the corpus callosum NFIB deficiency leads to neurological defects severe lung hypoplasia, whereas Nfic knockout mice exhibit tooth...
Endoluminal reconstruction with flow-diverting stents represents a widely accepted technique for the treatment of complex intracranial aneurysms. This European registry study analyzed initial experience 15 neurovascular centers Flow-Redirection Intraluminal Device (FRED) system.Consecutive patients aneurysms treated FRED between February 2012 and March 2015 were retrospectively reviewed. Complications adverse events, transient permanent morbidity, mortality, occlusion rates evaluated.During...
Background and purpose The focus of this study was to determine ease deployment, safety effectiveness the LVIS Jr device. Methods A retrospective analysis performed 32 cases comprising 34 aneurysms in which device used for stent-assisted coil embolization intracranial from February October 2012, including all clinical angiographic data as well mid-term follow-up (1–12 months treatment). Results median age patients 54 years (range 21–76) 19 (59%) were women. ruptured 12/34 (35.3%); 26 (76.4%)...
The safety and efficacy of the Woven EndoBridge (WEB) device for treatment cerebral aneurysms has been investigated in several studies. Our objective was to report experience 2 neurovascular centers with WEB broad-based intracranial aneurysms, including technical feasibility as well short- midterm angiographic clinical follow-up-results.We performed a retrospective analysis all ruptured unruptured treated (WEB Single-Layer Sphere) between August 2014 February 2017. Primary outcome measures...
The Contour is a novel intra-aneurysmal flow disrupting device to treat intracranial aneurysms.To evaluate the safety and effectiveness of for treatment nonruptured bifurcation aneurysms through prospective, multicenter, single-arm study.Thirty-four patients were enrolled. Primary end points successful occlusion at 6 mo efficacy any major stroke or nonaccidental death up 30 d disabling within safety. Secondary 12 mo, retreatment rate, procedure time, procedure-related/device-related adverse...
Chronic subdural hematoma (CSDH) is a common neurosurgical condition with high recurrence rates. Repeated microbleedings from fragile neo-vessels supplied by peripheral branches of the middle meningeal artery (MMA) are believed to be responsible for growth and CSDH. Thus, MMA embolization might promising method prevent re-bleedings recurrences. This study aims assess efficacy, complication rates, mid-term outcome or without burr hole irrigation compared alone.Patients diagnosed CSDH who...
The therapeutic impact of tumor resection is poorly defined. Therefore the current study was conducted.A retrospective, 2-institutional conducted (1991-1994) to compare treatment results stereotactic biopsy plus radiation therapy (99 patients; dose: 60 gray [Gy]) with those surgical (126 Gy). Only adult patients supratentorial, lobar located, de novo glioblastoma were included. Survival time analyzed Kaplan-Meier method. Prognostic factors obtained from multivariate Cox proportional hazards...
Abstract This investigation is based on measurements of 60 macerated adult European skulls from the Alexander-Ecker Collection at Anatomy Department University Freiburg. Computer tomographical (CT) and anatomical were compared to assess accuracy CT representation osseous structures. Nine structures examined: optic canal; superior orbital fissure; foramen rotundum; ovale; spinosum; Vesalii (venosum); carotid internal auditory canal, hypoglossal canal. The results show a good even excellent...
Background and purpose Thrombectomy has become the standard of care for acute ischaemic stroke due to large vessel occlusion. Aim this study was compare radiological outcomes time metrics various thrombectomy techniques. Methods In retrospective, multicenter we analysed data 450 patients with occlusion anterior circulation, treated in five high-volume center from 2013 2016. The treatment techniques were divided three categories: first-pass use a large-bore aspiration-catheter;...
<h3>BACKGROUND AND PURPOSE:</h3> The safety and efficacy of the Woven EndoBridge (WEB) device for treatment cerebral aneurysms have been investigated in several studies. Most these studies focused on specific or a certain WEB device. Our objective was to report experience 2 German centers with device, including technical feasibility, safety, short-term angiographic outcome. <h3>MATERIALS METHODS:</h3> We performed retrospective study all ruptured unruptured that were treated (WEB...
<h3>BACKGROUND AND PURPOSE:</h3> The safety and efficiency of the dual-layer Woven EndoBridge (WEB) device has already been published. However, this international multicenter study sought to evaluate single-layer devices, which are newest generation WEB intrasaccular flow-disrupter family. They have designed offer smaller-sized devices with a lower profile optimize navigability delivery, may, in turn, broaden their range use. <h3>MATERIALS METHODS:</h3> Data from all consecutive patients...
Endovascular embolization of intracranial aneurysms with hydrogel-coated coils lowers the risk major recurrence, but technical limitations (coil stiffness and time restriction for placement) have prevented their wider clinical use. We aimed to assess efficacy softer, second-generation hydrogel coils.A randomized controlled trial was conducted at 22 centers in France Germany. Patients aged 18 75 years untreated ruptured or unruptured measuring 4 12 mm diameter were eligible (1:1 using a...
Background Due to its high efficacy, flow diversion is increasingly used in the management of unruptured and recanalized aneurysms. Because need for perioperative dual antiplatelet treatment (DAPT), not indicated ruptured To overcome this major limitation, surface modification—‘coating’—of diverters has been developed reduce platelet aggregation on implanted device, thromboembolic complications, facilitate use coated diverter patients with single (SAPT). COATING (Coating Optimize Aneurysm...
Vessel perforation during thrombectomy is a severe complication and hypothesized to be more frequent medium vessel occlusion (MeVO) thrombectomy. The aim of this study was compare the incidence outcome patients with MeVO large (LVO) report on procedural steps that led perforation.
Head and neck paragangliomas (HNPs) pheochromocytomas are rare tumors. Sporadic hereditary forms recognized. Four different paraganglioma syndromes (PGLs 1–4) have been described: PGL 1 is associated with mutations of the succinate dehydrogenase (SDH) subunit D (SDHD) gene; 3 caused by SDHC gene mutations; 4 SDHB susceptibility for 2 unknown. The objective this study to review distinct clinical features PGLs. An international registry HNPs was founded in Freiburg, Germany, 2000. data...