A5067125690- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Cerebrospinal fluid and hydrocephalus
- Spectroscopy Techniques in Biomedical and Chemical Research
- Fetal and Pediatric Neurological Disorders
- Spectroscopy and Chemometric Analyses
- Neurological disorders and treatments
- Spinal Dysraphism and Malformations
- Tuberous Sclerosis Complex Research
- Neuroblastoma Research and Treatments
- Optical Imaging and Spectroscopy Techniques
- Meningioma and schwannoma management
- Neonatal and fetal brain pathology
- Neurofibromatosis and Schwannoma Cases
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Parkinson's Disease Mechanisms and Treatments
- Chromatin Remodeling and Cancer
- Advanced MRI Techniques and Applications
- Head and Neck Surgical Oncology
- Diverse academic and cultural studies
- Renal Diseases and Glomerulopathies
- Genetic Neurodegenerative Diseases
- Optical Coherence Tomography Applications
Meyer Children's Hospital
2016-2025
University of Florence
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
Meyer Children's Hospital
2008-2024
Accademia di Belle Arti di Frosinone
2024
Ospedale Santa Maria
2024
Agostino Gemelli University Polyclinic
2024
University of Amsterdam
2024
Amsterdam Neuroscience
2024
University Medical Center Utrecht
2024
Purpose To delineate clinically relevant molecular signatures of intracranial ependymoma. Materials and Methods We analyzed 24 primary ependymomas. For genomic profiling, microarray-based comparative hybridization (CGH) was used results were validated by fluorescent in situ loss heterozygosity mapping. performed gene expression profiling using microarrays, real-time quantitative reverse transcriptase polymerase chain reaction, methylation analysis selected genes. applied class comparison...
The variability in the clinical phenotype of Parkinson's disease seems to suggest existence several subtypes disease. To test this hypothesis we performed a cluster analysis using data assessing both motor and non-motor symptoms large cohort newly diagnosed untreated PD patients.We collected on demographic, motor, whole complex from 100 consecutive outpatients. Statistical allowed identification different subgroups, which have been subsequently explored.The driven approach identified four...
<h3>Background</h3> Non-motor symptoms are very common among patients with Parkinson9s disease since the earliest stage, but little is known about their progression and relationship dopaminergic replacement therapy. <h3>Methods</h3> We studied non-motor before after 2 years from therapy introduction in ninety-one newly diagnosed previously untreated PD patients. <h3>Results</h3> At baseline, nearly all (97.8%) referred at least one symptom. follow-up, only few significantly changed....
Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared lesional patients. In this study, we aimed to characterize large group patients who underwent despite normal and had no lesion histopathology. Determinants their postoperative seizure outcomes were further studied.
Abstract Background COVID-19 pandemic is thought to have changed the epidemiology of some pediatric neurosurgical disease: among them are intracranial complications sinusitis and otitis (ICSO). According studies on a limited number cases, both streptococci-related ICSO would increased immediately after pandemic, although reason not clear yet (seasonal changes versus pandemic-related effects). The goal present survey European Society for Pediatric Neurosurgery (ESPN) was collect large cases...
Summary Objective To report on six patients with SCN 1A mutations and malformations of cortical development ( MCD s) describe their clinical course, genetic findings, electrographic, imaging, neuropathologic features. Methods Through our database epileptic encephalopathies, we identified 120 mutations, which 4 had magnetic resonance imaging MRI) evidence s. We collected two further similar observations through the European Task‐force for Epilepsy Surgery in Children. Results The study group...
Background: Longitudinal studies on healthy participants have shown that subjective memory impairment (defined as cognitive complaints with normal objective performance) might be a strong predictor of mild (MCI). Parkinson disease (PD) also manifests disturbances, but whether may predict the development MCI in PD has not yet been explored. Methods: We prospectively screened newly diagnosed, untreated patients order to evaluate over 2-year follow-up evaluation. Results: enrolled 76 de novo...
Abstract Objective This study was undertaken to prospectively assess the frequency and type of psychiatric disorders (PDs) in pediatric surgical candidates evaluate effects epilepsy surgery on their psychopathological profile. Methods is a prospective controlled study. Psychopathology assessed using both diagnostic interviews questionnaires completed by clinicians, parents, whenever possible, patients, at baseline (T0) 1 year after operated patients (T1) first evaluation control group...
With two study protocols, one retrospective and the other prospective, we evaluated hypothalamo-hypophysial dysfunction (HHD) in paediatric patients treated for traumatic brain injury (TBI) neurosurgical or intensive care department at our hospital. The group comprised 22 who had experienced TBI 0.7-7.25 years before study. prospective included 30 assessed (T0), 26 of after 6 months (T6), 20 12 (T12). Auxological hormonal basal parameters function were recall group, T0, T6 T12 group. Basal...
Subependymal giant‐cell astrocytoma (SEGA) is a rare intra‐ventricular low‐grade tumor which frequently occurs as manifestation of tuberous sclerosis complex. The histogenesis SEGA controversial and its astrocytic nature has been doubted. First studies suggested the while several recent reports demonstrate glio‐neuronal nature. In spite this, in recently revised WHO classification CNS tumors, still included group astrocytomas. We studied nine complex‐associated SEGAs. Patients were 1–18...
Somatic and germline duplications or activating mutations of AKT3 have been reported in patients with hemimegalencephaly megalencephaly. We performed array comparative genomic hybridization on brain tissue blood 16 consecutive symptomatic epilepsy due to focal multilobar malformations cortical development who underwent surgical treatment epilepsy. One patient infantile spasms a dysplastic left frontal lobe harboured somatic trisomy the 1q21.1-q44 chromosomal region, encompassing gene, but...
// Anika Bongaarts 1, * , Krinio Giannikou 2, Roy J. Reinten 1 Jasper Anink James D. Mills Floor E. Jansen 3 Wim G.M. Spliet 4 Willfred F.A. den Dunnen 5 Roland Coras 6 Ingmar Blümcke Werner Paulus 7 Theresa Scholl 8 Martha Feucht Katarzyna Kotulska 9 Sergiusz Jozwiak 10 Anna Maria Buccoliero 11 Chiara Caporalini Flavio Giordano 12 Lorenzo Genitori Figen Söylemezoğlu 13 José Pimentel 14 Mark Nellist 15 Antoinette Y.N. Schouten-van Meeteren 16 Anwesha Nag 17 Angelika Mühlebner David...
Tuberous sclerosis complex (TSC) is a genetic disease presenting with multiple neurological symptoms including epilepsy, mental retardation, and autism. Abnormal activation of various inflammatory pathways has been observed in astrocytes brain lesions associated TSC. Increasing evidence supports the involvement microRNAs regulation astrocyte‐mediated response. To study role inflammation‐related TSC, we employed real‐time PCR situ hybridization to characterize expression miR21, miR146a,...
Summary Objective To analyze the attitude and results of Italian epilepsy surgery centers in surgical management “low grade associated neuroepithelial tumors” ( LEAT s). Methods We conducted a retrospective study enrolling 339 consecutive patients with s who underwent between January 2009 June 2015 at eight centers. compared demographic, clinical, pathologic, features favorable (Engel class I) unfavorable II , III, IV ) seizure outcome. In addition, we tumor‐associated focal cortical...
Abstract Background Chiari malformation type 1 (CM1) is a rare condition where agreed classification and treatment are still missing. The goal of this study to achieve consensus on the diagnosis CM1 in children. Methods A multidisciplinary panel formulated 57 provisional statements based review literature. Thirty-four international experts (IE) participated Delphi by independently rating each statement 4-point Likert scale (“strongly disagree,” “disagree,” “agree,” “strongly agree”)....
Vessel perforation during thrombectomy is a severe complication and hypothesized to be more frequent medium vessel occlusion (MeVO) thrombectomy. The aim of this study was compare the incidence outcome patients with MeVO large (LVO) report on procedural steps that led perforation.
The surgical procedure for severe, drug-resistant, unilateral hemispheric epilepsy is challenging. Over the last decades landscape disconnection procedures changed from anatomical hemispherectomy to functional hemispherotomy with a reduction of complications and stable good seizure outcome. Here, task force European surgeons prepared, on behalf EANS Section Functional Neurosurgery, consensus statement different aspects procedure. To determine history, indication, timing, techniques, current...
Abstract Objective Epilepsy surgery is a standard treatment for drug‐resistant epilepsy, resulting in seizure freedom significant number of cases. Although frequently performed low‐grade brain tumors, it rarely considered high‐grade despite the impact chronic epilepsy on quality life and cognition. Methods This retrospective multicenter study across 43 European centers evaluated outcomes children with tumors (World Health Organization grades III IV). Two cohorts patients younger than 25...
Object Neuroendoscopic surgery is being used as an alternative to traditional shunt and craniotomy in the management of hydrocephalus intracranial fluid-filled cavities. In this study, authors evaluated incidence type complications occurring after neuroendoscopic procedures that were performed a consecutive series pediatric patients at single institution determine effectiveness neuroendoscopy such patients. Methods Four hundred ninety-five consecutively 450 one over 10-year period. Charts...