Francesco Deleo
A5053193830- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Autoimmune Neurological Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Infectious Encephalopathies and Encephalitis
- Radiomics and Machine Learning in Medical Imaging
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Peripheral Neuropathies and Disorders
- Head and Neck Surgical Oncology
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
- Neurological disorders and treatments
- Long-Term Effects of COVID-19
- Advanced MRI Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- Advanced Neural Network Applications
Fondazione IRCCS Istituto Neurologico Carlo Besta
2016-2025
Stichting Epilepsie Instellingen Nederland
2024
University of Amsterdam
2024
Amsterdam Neuroscience
2024
University of Florence
2022-2024
Brazilian Institute of Neuroscience and Neurotechnology
2024
Universidade Estadual de Campinas (UNICAMP)
2022-2024
Meyer Children's Hospital
2022-2024
University Medical Center Utrecht
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023
ABSTRACT Pre‐surgical and post‐surgical data were examined compared from 215 consecutive patients undergoing surgery for intractable epilepsy. Patients selected on the basis of a proven histopathological diagnosis type I focal cortical dysplasia (FCD I), alone or associated with other lesions. The divided into five sub‐groups: i) 66 isolated FCD I, ii) 76 hippocampal sclerosis, iii) 49 tumours, iv) 16 malformations development v) eight anoxic‐ischaemic inflammatory diseases. duration...
ABSTRACT Focal cortical dysplasias (FCDs) are highly epileptogenic malformations associated with drug‐resistant epilepsy, susceptible to surgical treatment. Among the different types of FCD, type II includes two subgroups based on absence (IIa) or presence (IIb) balloon cells. The aim this retrospective study was investigate possible differences in electroclinical presentations and outcomes between 100 consecutive surgically treated patients FCDs. All underwent a comprehensive presurgical...
Magnetic resonance imaging-positive temporal lobe atrophy with temporo-polar grey/white matter abnormalities (usually called 'blurring') has been frequently reported in patients epilepsy associated hippocampal sclerosis. The poor distinction of grey and white attributed to various causes, including developmental cortical abnormalities, gliosis, myelin alterations, a non-specific increase water content metabolic/perfusion alterations. However, there is still no consensus regarding the genesis...
To test the hypothesis that a multicenter-validated computer deep learning algorithm detects MRI-negative focal cortical dysplasia (FCD).We used clinically acquired 3-dimensional (3D) T1-weighted and 3D fluid-attenuated inversion recovery MRI of 148 patients (median age 23 years [range 2-55 years]; 47% female) with histologically verified FCD at 9 centers to train convolutional neural network (CNN) classifier. Images were initially deemed in 51% patients, whom intracranial EEG determined...
Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared lesional patients. In this study, we aimed to characterize large group patients who underwent despite normal and had no lesion histopathology. Determinants their postoperative seizure outcomes were further studied.
ABSTRACT The present study included analysis of data from 243 patients surgically treated for Temporal Lobe Epilepsy (TLE). Resection was confined to the temporal lobe, with at least two years follow‐up, and specimens sufficiently preserved allow a precise evaluation both lateral neocortex hippocampus. frequency different types lesion hippocampal sclerosis (HS), isolated or associated neocortical lesions, risk factors surgical outcomes in relation neuropathological findings were evaluated....
Hippocampal sclerosis (HS) is the most frequent neuropathologic finding in patients undergoing surgery for intractable temporal lobe epilepsy (TLE). The International League Against Epilepsy (ILAE) has recently proposed a new classification of HS based on specific patterns cell loss. aim this study was to investigate relationships between types, their etiologic factors, and short- long-term postsurgical outcomes because drug-resistant TLE with HS.Two hundred thirteen diagnosis minimum...
In patients with temporal lobe epilepsy (TLE), assessment of language lateralization is important as anterior lobectomy may lead to impairments. Despite the widespread use fMRI, evidence its usefulness in predicting postsurgical performance scant. We investigated whether preoperative functional related performance, peri-ictal aphasia, and can predict outcome one year post-surgery. studied a total 72 TLE (42 left, 30 right), by using three fMRI tasks: Naming, Verb Generation Fluency....
Abstract Neuronal dendritic arborizations and spines are crucial for a normal synaptic transmission may be critically involved in the pathophysiology of epilepsy. Alterations morphology spine loss mainly hippocampal neurons have been reported both epilepsy animal models human brain tissues from patients with However, it is still unclear whether these abnormalities relate to cause or generated by seizure recurrence. We investigated fine neuronal structures at level organization using Golgi...
In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Studies performed a naturalistic setting are useful complement to characterize the drug profile. This multicentre study assessed effectiveness and tolerability of adjunctive BRV large population epilepsy context real-world clinical practice. The BRIVAFIRST (BRIVAracetam First Italian netwoRk STudy) was retrospective, including adult prescribed BRV. Patients...
Abstract The identification of the epileptogenic zone (EZ) boundaries is crucial for effective focal epilepsy surgery. We verify value a neurophysiological biomarker ictogenesis, characterized by low‐voltage fast‐activity ictal pattern (chirp) recorded with intracerebral electrodes during invasive presurgical monitoring (stereoelectroencephalography [SEEG]). frequency content SEEG signals was retrospectively analyzed semiautomatic software in 176 consecutive patients epilepsies that either...
OBJECTIVE Epilepsy surgery is an effective means of treating focal epilepsy associated with long-term epilepsy-associated tumors. This study evaluated a large population surgically treated patients childhood onset and histologically confirmed diagnosis The authors analyzed seizure outcomes to establish whether the time patients' ages were determinant factors. METHODS separately investigated several presurgical, surgical, postsurgical variables in operated on before (pediatric group) at or...
Objective The contribution of recurring seizures to the progression epileptogenesis is debated. Seizure‐induced brain damage not conclusively demonstrated either in humans or animal models epilepsy. We evaluated expression injury biomarkers on postsurgical tissue obtained from 20 patients with frequent and a long history drug‐resistant focal Methods patterns specific glial, neuronal, inflammatory molecules were by immunohistochemistry core type II cortical dysplasias (FCD‐II), at FCD...
Objective To describe the clinical and paraclinical findings, treatment options long-term outcomes in autoimmune encephalitis (AE), with a close look to epilepsy. Methods In this retrospective observational cohort study, we enrolled patients new-onset seizures context of AE. We compared findings without evidence antibodies. Results Overall, 263 (138 females; median age 55 years, range 4–86) were followed up for time 30 months (range 12–120). Antineuronal antibodies detected 63.50%....
This retrospective study assessed long-term effectiveness of add-on perampanel (PER) in patients with Lennox-Gastaut syndrome (LGS). Outcomes included time to PER failure and seizure relapse responders. was defined as either discontinuation or initiation another treatment. Seizure responders occurrence a seizure-free increase at least 50% average monthly frequency for those who were Eighty-seven included. Treatment occurred 52 (59.8%) subjects median 12 months. due lack efficacy 27 (52.0%)...
Abstract Musicogenic epilepsy (ME) is characterized by seizures triggered music. The epileptogenic focus in this rare reflex often the temporal lobe, although precise localization still unclear. A correlation between ME and presence of GAD65 antibodies indicates a potential immunological pathogenic mechanism. We evaluated 32‐year‐old woman with drug‐resistant lobe as candidate for surgery. In absence clear clinical lateralizing signs, video‐EEG monitoring intracranial electrodes inserted...
Subjects with intellectual disability are usually excluded from clinical trials and there is limited evidence-based guidance for the choice of antiseizure medications in this vulnerable population. The study explored effectiveness brivaracetam (BRV) people epilepsy disability. BRIVAracetam add-on First Italian netwoRk Study (BRIVAFIRST) was a 12-month retrospective, multicenter including adults prescribed adjunctive BRV. Main outcomes included rates seizure‐freedom, seizure response (≥ 50%...