A5090676395- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Drug Transport and Resistance Mechanisms
- Ethics in Clinical Research
- Health and Medical Research Impacts
- Delphi Technique in Research
- Statistical Methods in Clinical Trials
- Artificial Intelligence in Healthcare and Education
- Parallel Computing and Optimization Techniques
- Medical Imaging Techniques and Applications
- Embedded Systems Design Techniques
- Healthcare cost, quality, practices
- Sex and Gender in Healthcare
- Pharmacy and Medical Practices
- Advanced Causal Inference Techniques
- Digital Mental Health Interventions
- Pharmaceutical industry and healthcare
- Cystic Fibrosis Research Advances
- Pharmaceutical Practices and Patient Outcomes
- Fetal and Pediatric Neurological Disorders
- Anesthesia and Sedative Agents
Medisch Centrum Haaglanden
2020-2022
Utrecht University
2015-2022
University Medical Center Utrecht
2015-2022
Heidelberg University
2022
University Hospital Heidelberg
2022
National Hospital for Neurology and Neurosurgery
2022
University College London
2017-2022
University of Southern Denmark
2022
Sahlgrenska University Hospital
2018
University of Gothenburg
2018
<h3>Objective</h3> Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. <h3>Methods</h3> Sixteen European centers retrospectively identified cohorts of children adults who underwent epilepsy the period 1997 to 1998 (n = 562) or 2012 2013 736). Data collected included patient (sex, age) disease (duration, localization...
Many randomized controlled trials (RCTs) are biased and difficult to reproduce due methodological flaws poor reporting. There is increasing attention for responsible research practices implementation of reporting guidelines, but whether these efforts have improved the quality RCTs (e.g., lower risk bias) unknown. We, therefore, mapped risk-of-bias trends over time in RCT publications relation journal author characteristics. Meta-information 176,620 published between 1966 2018 was extracted....
Summary Objective Over the past decades, number of epilepsy surgeries in children has increased and indications for surgery have broadened. We studied changes patient characteristics between 1990 2011 a nationwide cohort related these to seizure outcome postoperative medication status. Second, we tried identify predictors after pediatric surgery. Methods To study over time, divided this retrospective 234 into two consecutive time periods 11 years, statistically compared epochs terms...
Abstract Objective Children with refractory focal epilepsy differ from adults, although many centers will offer invasive electroencephalography (iEEG) to both. Outcomes in terms of likelihood resection and subsequent seizure outcome after either subdural grid electrode implantation (SDE) or stereoelectroencephalography (SEEG) have, however, not been directly compared between age groups. Methods We retrospectively included adults children undergoing iEEG monitoring at four European centers....
The goals of intentional curative pediatric epilepsy surgery are to achieve seizure-freedom and antiepileptic drug (AED) freedom. Retrospective cohort studies have indicated that early postoperative AED withdrawal unmasks incomplete surgical success dependency sooner, but not at the cost long-term seizure outcome. Moreover, seemed improve cognitive A randomized trial is needed confirm these findings. We hypothesized in children only safe, also beneficial with respect functioning. This a...
Summary The objective of this study was to create a clinically useful tool for individualized prediction seizure outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery. We used data from the European retrospective TimeToStop study, which included 766 children 15 centers, perform proportional hazard regression analysis. 2 outcome measures were recurrence and freedom in last year follow‐up. Prognostic factors identified through systematic review literature. strongest...
More than half of adults with epilepsy undergoing resective surgery achieve long-term seizure freedom and might consider withdrawing antiseizure medications. We aimed to identify predictors recurrence after starting postoperative medication withdrawal develop validate predictive models. performed an international multicentre observational cohort study in nine tertiary referral centres. included 850 who started following were free seizures other focal non-motor aware before withdrawal....
ABSTRACT Aims . Following the results of multicentre European retrospective “TimeToStop” cohort study, we initiated a randomised trial to determine cognitive benefits early postoperative antiepileptic drug withdrawal. Unfortunately, failed recruit and was terminated, as almost all parents preferred The objectives current survey were obtain insight into practices regarding withdrawal after paediatric epilepsy surgery among epileptologists, better understand reasons for difficulties in...
The clinical profile of children who had possible seizures is heterogeneous, and accuracy diagnostic testing limited. We aimed to develop validate a prediction model that determines the risk childhood epilepsy by combining available information at first consultation.We retrospectively collected data 451 visited our outpatient department for workup related 1 or more paroxysmal event(s). At least year follow-up was all were diagnosed with in whom diagnosis remained inconclusive. Clinical...
Clinical trials have a vital role in ensuring the safety and efficacy of new treatments interventions medicine. A key characteristic clinical trial is its statistical power. Here we investigate whether power related to gender first last authors on paper reporting results trial. Based an analysis 31,873 published between 1974 2017, find that adequate was most often present with male author female (20.6%, 95% confidence interval 19.4-21.8%), this figure significantly higher than percentage for...
This cross-sectional study evaluates the existence and timing of trial registration for randomized clinical trials (RCTs) published from 2002 to 2017 as well substantive changes primary outcomes entered into registry information after those studies started.
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Antiseizure medication may have long-term effects on the neurodevelopment of children. We aimed to investigate association between cumulative antiseizure load and intelligence quotient (IQ) in relation brain volume cortical thickness.A retrospective analysis children with focal epilepsy who underwent neuropsychological assessment MRI ages 5-12 years a tertiary centre was performed. Cumulative presented years. studied total IQ multivariable linear regression, corrected for epilepsy-related...
Abstract More than half of adults with epilepsy undergoing resective surgery achieve long-term seizure freedom and might consider withdrawing antiseizure medications (ASMs). We aimed to identify predictors recurrence after starting postoperative ASM withdrawal develop validate predictive models. performed an international multicentre observational cohort study in nine tertiary referral centres. included 850 who started following were free seizures other focal non-motor aware (auras) before...
Abstract Background Many randomized controlled trials (RCTs) are biased and difficult to reproduce due methodological flaws poor reporting. There is increasing attention for responsible research practices including reporting guidelines, but it unknown whether these efforts have improved RCT quality (i.e. reduced risk of bias). We therefore mapped trends over time in trial publication, registration, according CONSORT, characteristics publication authors. Methods Meta-information 176,620 RCTs...