A5041468356- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Autoimmune Neurological Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Infectious Encephalopathies and Encephalitis
- Acute Ischemic Stroke Management
- Genetic Neurodegenerative Diseases
- Neurological and metabolic disorders
- Glioma Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Stroke Rehabilitation and Recovery
- Metabolism and Genetic Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Functional Brain Connectivity Studies
- Hemoglobinopathies and Related Disorders
- Advanced MRI Techniques and Applications
- Peripheral Neuropathies and Disorders
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Advanced Chemical Sensor Technologies
- Multiple Sclerosis Research Studies
- Olfactory and Sensory Function Studies
Policlinico di Modena
2018-2024
University of Modena and Reggio Emilia
2015-2024
Azienda Unita' Sanitaria Locale Di Modena
2015-2024
IRCCS Eugenio Medea
2024
Ospedale Policlinico San Martino
2024
Universidad Alfonso X el Sabio
2020
National Operating Committee on Standards for Athletic Equipment
2019
Azienda Sanitaria Unità Locale di Reggio Emilia
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
Christian Doppler Klinik
2018
Summary Objective In 2015, the International League Against Epilepsy ( ILAE ) proposed a new definition of status epilepticus SE ): 5 minutes ongoing seizure activity to diagnose convulsive CSE , ie, bilateral tonic–clonic and 10 for focal absence rather than earlier criterion 30 minutes. Based on semiology, several types with prominent motor phenomena at any time (including were distinguished from those without (ie, nonconvulsive NCSE ). We present first population‐based incidence study...
To characterize the clinical, EEG, and brain imaging findings in an adult case series of patients with de novo refractory status epilepticus (SE) occurring after a febrile illness.
This study aimed to group acute symptomatic etiologies of consecutive episodes status epilepticus (SE) into different subcategories and explore their associations with clinical outcome. Etiologies were first categorized as "acute," "remote," "progressive," "SE in defined electroclinical syndromes," "unknown." Four then defined: (1) withdrawal, low levels, or inappropriate prescription antiseizure medications, sleep deprivation patients pre-existing epilepsy; (2) insults central nervous...
Abstract Objective Status epilepticus (SE) may lead to long‐term consequences. This study evaluated the risk and predictors of seizure occurrence after SE, with a focus on SE due acute symptomatic etiologies. Methods Prospectively collected data about adults surviving first non‐hypoxic were reviewed. The outcome was unprovoked seizures during follow‐up. Kaplan–Meier survival curve analysis log‐rank test used analyze time determine statistical significance between etiological groups. Three...
New-onset refractory status epilepticus (NORSE) is a rare but challenging condition occurring in previously healthy patient, often with no identifiable cause. We describe the electro-clinical features and outcomes group of patients NORSE who all demonstrated typical magnetic resonance imaging (MRI) sign characterized by bilateral lesions claustrum. The includes 31 (12 personal 19 published cases; 17 females; mean age 25 years). Fever preceded (SE) 28 patients, 6 days. SE was...
Magnetic resonance imaging (MRI) provides an opportunity for identifying peri-ictal MRI abnormalities (PMAs) related to status epilepticus (SE). Extremely variable alterations have been reported previously during or after SE, mainly in small selected populations. In a retrospective monocentric study, we analyzed brain changes observed the ictal/postictal periods of SE adult population. We included all consecutive patients 5-year period with electroclinical diagnosis and performed within 30...
Objective To describe the clinical and paraclinical findings, treatment options long-term outcomes in autoimmune encephalitis (AE), with a close look to epilepsy. Methods In this retrospective observational cohort study, we enrolled patients new-onset seizures context of AE. We compared findings without evidence antibodies. Results Overall, 263 (138 females; median age 55 years, range 4–86) were followed up for time 30 months (range 12–120). Antineuronal antibodies detected 63.50%....
Abstract Biomarkers of neuronal damage in status epilepticus (SE) would be great relevance for clinical and research purposes. In a retrospective cross‐sectional study, serum neurofilament light chain (NfL) levels were measured patients with SE (30 subjects), drug‐resistant epilepsy healthy controls subjects). Serum NfL higher (median = 26.15 pg/ml) compared to both 7.35 6.81 pg/ml; p < .001). SE, showed high correlation cerebrospinal fluid (CSF) (τ .68, .001) as well CSF total tau...
Abstract Considering the growing age of world population, incidence epilepsy in older adults is expected to increase significantly. It has been suggested that late-onset temporal lobe (LO-TLE) may be neurodegenerative origin and overlap with Alzheimer’s disease (AD). Herein, we aimed characterize pattern cortical atrophy CSF biomarkers AD (total phosphorylated tau amyloid-β) a selected population LO-TLE unknown origin. We prospectively enrolled individuals onset after 50 no cognitive...
Summary Neuroactive steroids are increasingly considered as relevant modulators of neuronal activity. Especially allopregnanolone ( AP ) and pregnenolone sulfate PS have been shown to possess, respectively, anticonvulsant or proconvulsant properties. In view the potential role these steroids, we aimed at evaluating levels in cerebrospinal fluid CSF blood samples obtained from patients with status epilepticus SE ). To this purpose, enrolled 41 affected by subjects investigated for...
Together with hippocampus, the amygdala is important in epileptogenic network of patients temporal lobe epilepsy. Recently, an increase volumes (i.e. enlargement) has been proposed as morphological biomarker a subtype epilepsy without MRI abnormalities, although other data suggest that this finding might be unspecific and not exclusive to In these studies, treated single entity, while instead it composed different nuclei, each peculiar function connection. By adopting recently developed...
To evaluate in a real clinical scenario the impact of ILAE-recommended "Harmonized neuroimaging epilepsy structural sequences"- HARNESS protocol patients affected by focal epilepsy.We prospectively enrolled who underwent brain MRI between 2020 and 2021 at Modena University Hospital. For all patients, MRIs were: (a) acquired according to HARNESS-MRI (H-MRI); (b) reviewed same neuroradiology team. outcomes measures number positive (diagnostic) negative MRI; type radiological diagnosis...
Long-term consequences after status epilepticus (SE) represent an unsettled issue. We investigated the incidence of remote unprovoked seizures (RS) and drug-resistant epilepsy (DRE) in a cohort first-ever SE survivors.