Silvio Brusaferro

ORCID: 0000-0003-1018-7094
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About
Contact & Profiles
Research Areas
  • SARS-CoV-2 and COVID-19 Research
  • Vaccine Coverage and Hesitancy
  • COVID-19 epidemiological studies
  • COVID-19 Clinical Research Studies
  • Infection Control in Healthcare
  • Antibiotic Use and Resistance
  • Patient Safety and Medication Errors
  • Nosocomial Infections in ICU
  • Health Systems, Economic Evaluations, Quality of Life
  • COVID-19 and healthcare impacts
  • Long-Term Effects of COVID-19
  • Influenza Virus Research Studies
  • Healthcare Quality and Management
  • Geriatric Care and Nursing Homes
  • Quality and Safety in Healthcare
  • Healthcare Facilities Design and Sustainability
  • COVID-19 Pandemic Impacts
  • Medical Malpractice and Liability Issues
  • Emergency and Acute Care Studies
  • Pharmaceutical Practices and Patient Outcomes
  • Healthcare cost, quality, practices
  • Viral gastroenteritis research and epidemiology
  • Antibiotic Resistance in Bacteria
  • Medical Device Sterilization and Disinfection
  • COVID-19 and Mental Health

University of Udine
2016-2025

Istituto Superiore di Sanità
2019-2025

Azienda Unità Sanitaria Locale di Ferrara
2024

Ekiti State University
2023

Network Group (Czechia)
2023

Ospedale di Macerata
2023

University of Macerata
2023

Brunel University of London
2023

Lagos State Health Service Commission
2023

University of Catania
2023

This Viewpoint from physicians with the Italian National Institute of Health confirms a higher case-fatality rate coronavirus disease 2019 (COVID-19) in Italy compared China and explains possible reasons, including age, cause death definitions, testing strategy.

10.1001/jama.2020.4683 article EN JAMA 2020-03-23
Ann Versporten Peter Zarb Isabelle Caniaux Marie-Françoise Gros Nico Drapier and 95 more Mark L. Miller Vincent Jarlier Dilip Nathwani Herman Goossens Andi Koraqi Iris Hoxha Silva Tafaj Denada Lacej Martín Hojman Rodolfo Quirós Lilit Ghazaryan Kelly A. Cairns Allen C. Cheng Kylie Horne Fiona Doukas Thomas Gottlieb Jameela Alsalman Koen Magerman Gounongbe YT Marielle Amela Dedeić-Ljubović André Afonso Machado Coelho Ana Cristina Gales Emma Keuleyan Deana Sabuda Jennifer Boswell John Conly Álvaro Rojas Camila Carvajal Jaime Labarca Antonio L. Solano Carlos Ramírez Valverde Juan Villalobos-Vindas Irina Pristaš Vanda Plečko Niki I. Paphitou Erjona Shaqiri Maija-Liisa Rummukainen Karaman Pagava Irma Korinteli Tobias Brandt Sabine Messler Anthony Enimil Εlias Iosifidis Emmanuel Roilides Mamadou Saliou Sow Sharmila Sengupta Joby V. George Aruna Poojary Priyanka Patil Jafar Soltani Zahra Jafarpour Hadi Ameen David Fitzgerald ‪Yasmin Maor‬‏ Michal Chowers Elizabeth Temkin Susanna Esposito Luca Arnoldo Silvio Brusaferro Yoshiaki Gu Feras Darwish Elhajji Nam Joong Kim Baktygul Kambaralieva Jana Pavāre Lelde Zarakauska Vytautas Usonis Sigita Burokienė Inga Ivaškevičienė Gordana Mijović Nataša Duborija-Kovačević Kristen Bondesio Kenneth Iregbu O.O. Oduyebo Denis Raka Lul Raka Svetlana Rachina Mushira Enani Mohamed Al Shehri Biljana Carević Gorana Dragovac Dušanka Obradović Aleksandra Stojadinović Lili Radulovic Jia En Wu Gladys Wei Teng Chung Hui Hiong Chen Paul Anantharajah Tambyah David Chien Lye Sock Hoon Tan Tat Ming Ng Hui Lin Tay Moi Lin Ling Maciej Piotr Chlebicki Andrea Lay‐Hoon Kwa Winnie Lee

BackgroundThe Global Point Prevalence Survey (Global-PPS) established an international network of hospitals to measure antimicrobial prescribing and resistance worldwide. We aimed assess in hospital inpatients.MethodsWe used a standardised surveillance method collect detailed data about from worldwide, which were grouped by UN region. The internet-based survey included all inpatients (adults, children, neonates) receiving who on the ward at 0800 h one specific day between January September,...

10.1016/s2214-109x(18)30186-4 article EN cc-by-nc-nd The Lancet Global Health 2018-04-23

Background On 20 February 2020, a locally acquired coronavirus disease (COVID-19) case was detected in Lombardy, Italy. This the first signal of ongoing transmission severe acute respiratory syndrome 2 (SARS-CoV-2) country. The number cases Italy increased rapidly and country became Europe to experience SARS-CoV-2 outbreak. Aim Our aim describe epidemiology dynamics COVID-19 amid control measures. Methods We analysed all RT-PCR-confirmed reported national integrated surveillance system until...

10.2807/1560-7917.es.2020.25.49.2000790 article EN cc-by Eurosurveillance 2020-12-10

Abstract Background Aim of the present study is to describe characteristics COVID-19-related deaths and compare clinical phenotype course occurring in adults (<65 years) older (≥65 years). Method Medical charts 3,032 patients dying with COVID-19 Italy (368 aged < 65 years 2,664 ≥65 were revised extract information on demographics, preexisting comorbidities, in-hospital complications leading death. Results Older presented a higher number comorbidities compared those <65...

10.1093/gerona/glaa146 article EN other-oa The Journals of Gerontology Series A 2020-06-07

New SARS-CoV-2 mutations are constantly emerging, raising concerns of increased transmissibility, virulence or escape from host immune response. We describe a nested RT-PCR assay (~1500 bps) to detect multiple nucleotide changes resulting in key spike protein distinctive the major known circulating variants, including three Variants Concern (VOCs) 20I/501Y.V1 (United Kingdom), 20H/501Y.V2 (South Africa), and 20 J/501Y.V3 (Brazil), as well 20E.EU1 variant (Spain), CAL.20C recently identified...

10.1016/j.watres.2021.117104 article EN cc-by-nc-nd Water Research 2021-04-02

Background Our study aimed to estimate the prevalence of pregnancy e-health seekers in a large Italian sample; explore factors influencing choices childbearing women regarding their lifestyles after internet consultation; and finally investigate potential differences between primiparous multiparous use find information about pregnancy. Methods A multicentre survey was carried out seven cities. Data were collected through validated questionnaire administered waiting rooms outpatient...

10.1136/jech-2013-202584 article EN Journal of Epidemiology & Community Health 2013-09-26

Since electronic prescribing is limited to few hospitals, point prevalence surveys, such as the standardized European Surveillance of Antimicrobial Consumption survey (ESAC PPS), are an alternative tool for monitoring and helping identify performance indicators trends. The main objective this study was assess targets quality improvement. Each hospital had carry out within 2 weeks. department be surveyed in 1day. Data collected, all inpatients, included age gender. For patients on systemic...

10.1093/jac/dkq430 article EN Journal of Antimicrobial Chemotherapy 2010-11-17

SUMMARY Background In February 2020, a locally-acquired COVID-19 case was detected in Lombardia, Italy. This the first signal of ongoing transmission SARS-CoV-2 country. The outbreak rapidly escalated to national level epidemic, amid WHO declaration pandemic. Methods We analysed data from case-based integrated surveillance system all RT-PCR confirmed infections as March 24 th collected Italian regions and autonomous provinces. Here we provide descriptive epidemiological summary on 62,843...

10.1101/2020.04.08.20056861 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2020-04-11

Abstract Background Standardized mortality surveillance data, capable of detecting variations in total at population level and not only among the infected, provide an unbiased insight into impact epidemics, like COVID-19 (Coronavirus disease). We analysed temporal trend excess deaths positive cases SARS-CoV-2 by geographical area (north centre-south), age sex, taking account deficit previous months. Methods Data from Italian rapid system was used to quantify during epidemic, estimate months...

10.1186/s12889-020-09335-8 article EN cc-by BMC Public Health 2020-08-14

The eHealth Literacy Scale (eHEALS) is a tool for the self-assessment of perceived comfort and skills in using internet as source health-related information. Although evidence exists reliability construct structural validity scale, there lack relation to what proposed by Norman Skinner their theoretical lily model literacy; particular it not clear whether having higher level health literacy can positively influence electronic (eHealth) measured eHEALS.Our study aim was assess real-life...

10.2196/jmir.9401 article EN cc-by Journal of Medical Internet Research 2018-07-20

SARS-CoV-2 infection is heterogeneous in clinical presentation and disease evolution. To investigate whether immune response to the virus can be influenced by genetic factors, we compared HLA AB0 frequencies organ transplant recipients waitlisted patients according presence or absence of infection.A retrospective analysis was performed on an Italian cohort composed transplanted a January 2002 March 2020 time frame. Data from this were merged with registry COVID+ subjects, evaluating status...

10.1097/tp.0000000000003507 article EN Transplantation 2020-10-30

Significance We use a mathematical model to evaluate the Italian exit strategy after lockdown imposed against COVID-19 epidemics, comparing it number of alternative scenarios. highlight that successful reopening requires two critical conditions: low value reproduction and incidence infection. The first is needed allow some margin for expansion lifting restrictions; second because level will be maintained approximately constant has grown values close one. Furthermore, we suggest that, even...

10.1073/pnas.2019617118 article EN cc-by Proceedings of the National Academy of Sciences 2021-01-07

On March 11, 2020, Italy imposed a national lockdown to curtail the spread of severe acute respiratory syndrome coronavirus 2. We estimate that, 14 days after lockdown, net reproduction number had dropped below 1 and remained stable at »0.76 (95% CI 0.67-0.85) in all regions for >3 following weeks.

10.3201/eid2701.202114 article EN cc-by Emerging infectious diseases 2020-10-20

The International Classification of Sleep disorders, the Diseases and Diagnostic Statistical manual Mental Disorders defines insomnia as an experience insufficient or poor sleep quality, characterized by at least one following symptoms: difficulty in initiating maintaining sleep, early awakenings restorative sleep. In Italy, Morfeo 1 study detects a prevalence 20% 40% cases with day-time symptoms. chronic deprivation is responsible for cognitive disorders effects on social life. Being common...

10.7416/ai.2018.2247 article EN PubMed 2019-01-08

Since February 21 2020, when the Italian National Institute of Health (Istituto Superiore di Sanità-ISS) reported first autochthonous case infection, a dedicated surveillance system for SARS-CoV-2-positive (COVID+) cases has been created in Italy. These data were cross-referenced with those inside Information Transplant System order to assess cumulative incidence (CI) and outcome SARS-COV-2 infection solid organ transplant recipients (SOTRs) who are assumed be most at risk. We compared our...

10.1111/ajt.16428 article EN cc-by-nc-nd American Journal of Transplantation 2020-12-06

Abstract To counter the second COVID-19 wave in autumn 2020, Italian government introduced a system of physical distancing measures organized progressively restrictive tiers (coded as yellow, orange, and red) imposed on regional basis according to real-time epidemiological risk assessments. We leverage data from integrated surveillance publicly available mobility evaluate impact three-tiered restriction human activities, SARS-CoV-2 transmissibility hospitalization burden Italy. The...

10.1038/s41467-021-24832-z article EN cc-by Nature Communications 2021-07-27

Effectiveness against severe COVID-19 of a second booster dose the bivalent (original/BA.4-5) mRNA vaccine 7-90 days post-administration, relative to first an received ≥ 120 earlier, was ca 60% both in persons 60 years never infected and those > 6 months before. Relative effectiveness 4-6 earlier indicated no significant additional protection (10%; 95% CI: -44 44). A vaccination after latest infection may be warranted.

10.2807/1560-7917.es.2023.28.8.2300105 article EN cc-by Eurosurveillance 2023-02-23

Abstract Background A significant proportion of individuals reports persistent clinical manifestations following SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection. Nevertheless, knowledge the burden this condition—often referred to as ‘Long COVID’—on health care system remains limited. This study aimed evaluate healthcare utilization potentially related Long COVID. Methods Population-based, retrospective, multi-center cohort that analyzed hospital admissions and...

10.1093/eurpub/ckae001 article EN cc-by-nc European Journal of Public Health 2024-01-18

To examine the effectiveness of reflexology foot massage in hospitalized cancer patients undergoing second or third chemotherapy cycles.Since late-1970s, studies have been conducted to assess efficacy behavioural and relaxation approaches controlling nausea/vomiting, anxiety other side-effects associated with chemotherapy.The study consisted 30 being admitted oncology unit at a Scientific Research Hospital Italy. Only 15 participants received therapeutic massage. The subjects' self-reports...

10.1111/j.1365-2934.2006.00557.x article EN Journal of Nursing Management 2006-02-17
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