A5039807679- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Diabetes Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological Disorders and Treatments
- Schizophrenia research and treatment
- Organ Transplantation Techniques and Outcomes
- Pharmaceutical studies and practices
- Blood Pressure and Hypertension Studies
- Neurological disorders and treatments
- Antibiotic Use and Resistance
- Long-Term Effects of COVID-19
- Biosimilars and Bioanalytical Methods
- Pregnancy and Medication Impact
- Alzheimer's disease research and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pneumonia and Respiratory Infections
- Transplantation: Methods and Outcomes
- Dementia and Cognitive Impairment Research
- Amyotrophic Lateral Sclerosis Research
Istituto Superiore di Sanità
2010-2024
National Centre for Disease Prevention and Control
2014-2024
National Institutes of Health
2009-2015
Azienda Ospedaliero-Universitaria Careggi
2007-2008
University of Florence
2007-2008
University of Pisa
2007
Federico II University Hospital
2007
University of Padua
2007
Azienda Unita' Sanitaria Locale Di Modena
1999
Alleanza Contro il Cancro
1999
To estimate the effectiveness of mRNA vaccines against SARS-CoV-2 infection and severe covid-19 at different time after vaccination.
Cardiovascular disease (CVD) is the main cause of morbidity/mortality in diabetes. We set forth to determine incidence and identify predictors (including microvascular complications treatment) first coronary heart (CHD) event CVD-free type 2 diabetic patients.A cohort 6,032 women 5,612 men, sampled from a nationwide network hospital-based diabetes clinics, was followed up for 4 years. Baseline assessment included retinopathy, nephropathy, foot ulcers. First CHD events (myocardial infarction,...
<h3>Importance</h3> Convalescent plasma (CP) has been generally unsuccessful in preventing worsening of respiratory failure or death hospitalized patients with COVID-19 pneumonia. <h3>Objective</h3> To evaluate the efficacy CP plus standard therapy (ST) vs ST alone <h3>Design, Setting, and Participants</h3> This prospective, open-label, randomized clinical trial enrolled (1:1 ratio) pneumonia to receive between July 15 December 8, 2020, at 27 sites Italy. Hospitalized adults a partial...
Background Myocarditis and pericarditis following the Coronavirus Disease 2019 (COVID-19) mRNA vaccines administration have been reported, but their frequency is still uncertain in younger population. This study investigated association between Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) vaccines, BNT162b2, mRNA-1273 myocarditis/pericarditis population of vaccinated persons aged 12 to 39 years Italy. Methods findings We conducted a self-controlled case series (SCCS) using national data...
Type 2 diabetes mellitus is a strong predictor of cerebrovascular disease, yet few studies have assessed the incidence stroke and role other risk factors in unselected type populations.We prospectively followed-up 14,432 patients, aged 40 to 97 years, with without history cardiovascular disease at enrollment, we estimated hazards ratios respect clinical variables.During 4-year follow-up, 296 incident events were recorded. In persons no age-standardized (per 1000 person-years) was 5.5 (95%...
Introduction: COVID-19 case fatality rate in hospitalized patients varies across countries and studies. Reliable estimates, specific for age, sex, comorbidities, are needed to monitor the epidemic, compare outcome different settings, correctly design trials interventions. The aim of this study was provide population-based survival curves patients. Materials Methods: A cohort conducted three areas Northern Italy, heavily affected by SARS-CoV-2 infection (Lombardy Veneto Regions, Reggio Emilia...
The epidemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spreading globally, raising increasing concerns. There are several controversial hypotheses on the potentially harmful or beneficial effects of antihypertensive drugs acting renin–angiotensin–aldosterone system (RAAS) in disease 2019 (COVID-19). Furthermore, there is accumulating evidence, based observational studies, that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin...
Although the etiologic relation between nonsteroidal antiinflammatory drug (NSAID) use and gastrointestinal lesions is well documented, newly introduced NSAIDs deserve a fresh examination for their risk/benefit ratio. To estimate association consumption of ketorolac occurrence gastroduodenal lesions, we conducted case-control study. The study population comprised 600 outpatients with confirmed endoscopic diagnosis ulcer erosion in 1991 1992 6,000 community controls matched by age sex. We...
OBJECTIVE—The purpose of this study was to assess incidence and risk factors for recurrent cardiovascular disease (CVD) in type 2 diabetes. RESEARCH DESIGN AND METHODS—We estimated the events diabetic patients, aged 40–97 years, followed by a network diabetes clinics. The analysis conducted separately 2,788 patients with CVD at enrollment (cohort A) 844 developing first episode during observation period B). RESULTS—During 4 years follow-up, cohort A age-adjusted event (per 1,000...
To assess the risk of maternal, fetal, and neonatal outcomes associated with administration an MF59 adjuvanted A/H1N1 vaccine during pregnancy.Historical cohort study.Singleton pregnancies resident population Lombardy region Italy.All deliveries between 1 October 2009 30 September 2010. Data on exposure to pandemic vaccine, pregnancy, birth were retrieved from regional databases. Vaccinated non-vaccinated women compared in a propensity score matched analysis estimate risks adverse...
To assess the real-world impact of vaccines on COVID-19 related outcomes, we analysed data from over 7 million recipients at least one vaccine dose in Italy. Taking 0–14 days post-first as reference, SARS-CoV-2 infection risk subsequently decreased, reaching a reduction by 78% (incidence rate ratios (IRR): 0.22; 95% CI: 0.21–0.24) 43–49 dose. Similarly, hospitalisation and death risks with 89% (IRR: 0.11; 0.09–0.15) 93% 0.07; 0.04–0.11) reductions 36–42 Our results support ongoing...
Biological drugs have improved the management of immune-mediated inflammatory diseases (IMIDs) despite being associated with important safety issues such as immunogenicity, infections, and malignancies in real-world settings.The aim this study was to explore potential a large Italian multi-database distributed network for use postmarketing surveillance biological drugs, including biosimilars, patients IMID.A retrospective cohort conducted using 13 regional claims databases during 2010-2019....
Background Recently published studies have reported association of COVID-19 vaccine ChAdOx1-S (Vaxzevria) with Guillain Barré Syndrome (GBS). Less is known about the safety other vaccines respect to GBS outcome. This study investigated in more than 15 million persons aged ≥12 years Italy. Methods Study population was all individuals who received at least one dose vaccines, admitted emergency care/hospital for from 27 December 2020–30 September 2021 Identification cases and receipt mRNA-1273...
Background Switch patterns among different biologics and from originators to biosimilars (and vice versa) can be complex in patients with psoriasis (PsO) psoriatic arthritis (PsA).
The goal of post-transplant immunosuppressive drug therapy is to prevent organ rejection while minimizing toxicities. In clinical practice, a multidrug approach commonly used and involves drugs with different mechanisms action, including calcineurin inhibitors (CNI) (tacrolimus or cyclosporine), antimetabolite (antimet) (mycophenolate azathioprine), mechanistic target rapamycin (mTOR) (sirolimus everolimus), and/or steroids. Although evidence based on several randomized trials available, the...
<b><i>Article abstract</i></b> Cancer mortality in a population-based cohort of 10,322 parkinsonian patients (448 deaths observed during 1987 to 1994) was compared with that the Italian province Rome using standardized ratio (SMR). The overall cancer risk lower this than reference population (SMR, 56; 95% CI, 51 61). This reduction included most sites as well both smoking-related 51; 42 60) and nonsmoking-related cancers 58; 52 65). cannot be explained entirely by hypothesis smokers are less...
The objective of the study was to estimate prevalence parkinsonism in Province Rome using antiparkinsonian prescription histories from 1986 1991.A subject defined as a case if he/she had received "specific" and "consistent" therapy period.In November 1990, 6,572 patients were prevalent cases parkinsonism. crude ratio, for total population Rome, is 173.5 per 100,000 inhabitants (165.9 men 180.5 women). method validated by record-linkage with clinical records all visited during 1990 at...
Maintenance immunosuppressive therapy used in kidney transplantation typically involves calcineurin inhibitors, such as tacrolimus or cyclosporine, combination with mycophenolate mechanistic target of rapamycin (mTORi) without corticosteroids. An Italian retrospective multicentre observational study was conducted to investigate the risk-benefit profile different regimens. We identified all subjects who underwent transplant between 2009 and 2019, using healthcare claims data. Patients on...
Cases of appendicitis were identified in the pivotal randomized clinical trial on BNT162b2 mRNA vaccine and reported from coronavirus disease 2019 (COVID-19) pharmacovigilance systems. Three cohort studies two self-controlled case series (SCCS) evaluating association between vaccines discordant results. To address this uncertainty, present study examines a large population, with SCCS design, (BNT162b2 mRNA-1273) and, for first time, viral vector (ChAdOx1-S Ad26.COV2-S) COVID-19 acute appendicitis.
Cervical cancer screening is uncommon, especially in low-income countries and among lower socioeconomic status people high-income countries. The aims of this study were to examine the adherence Sicilian women Pap testing identify determinants a population with secondary prevention attitude than national average. A cross-sectional called "Save Eva Sicily" was conducted all aged 25⁻64 years, sample drawn by list general practitioners (GPs), using proportional sampling scheme, stratified age...