A5085817977- Pharmaceutical Practices and Patient Outcomes
- Schizophrenia research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Pharmaceutical studies and practices
- Blood Pressure and Hypertension Studies
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Atrial Fibrillation Management and Outcomes
- Respiratory and Cough-Related Research
- Pharmacological Effects and Toxicity Studies
- Diabetes Management and Research
- Mental Health Treatment and Access
- Treatment of Major Depression
- COVID-19 and Mental Health
- Pharmacology and Obesity Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Asthma and respiratory diseases
- Metabolism, Diabetes, and Cancer
- Pregnancy and Medication Impact
- Dementia and Cognitive Impairment Research
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
Regione Lombardia
2016-2025
Ministero della Salute
2016-2025
Lombardia Informatica (Italy)
2010-2025
Regional Health
2013-2020
Italian Medicines Agency
2019
Mario Negri Institute for Pharmacological Research
1997-2013
Istituti di Ricovero e Cura a Carattere Scientifico
2013
University of Milano-Bicocca
2011
FIT Consulting (Italy)
2011
Azienda Ospedaliera San Gerardo
2011
Guidelines recommend a combination of 2 drugs to be used as first-step treatment strategy in high-risk hypertensive individuals achieve timely blood pressure control and avoid early events. The evidence that this is associated with cardiovascular (CV) benefits compared initial monotherapy limited, however. objective study was assess whether, antihypertensive monotherapy, provides greater CV protection daily clinical practice. A population-based, nested case-control carried out by including...
To estimate the prevalence of potentially severe drug-drug interactions (DDIs) and their relationship with age, sex number prescribed drugs.We analysed all prescriptions dispensed from 1 January 2003 to 31 December individuals aged 65 or more registered under Local Health Authority Lecco, a northern Italian province population almost 330 000 persons. Elderly who received at least two co-administered were selected assess presence DDIs.The DDIs was 16%, rose increasing patient's age drugs...
GLP-1 receptor agonists (GLP-1 RA) and SGLT-2 inhibitors (SGLT-2i) have shown to reduce the risk of major adverse cardiovascular events (MACE), death worsening nephropathy when added standard care. However, these two dug classes differ in efficacy safety. We compared effectiveness safety profile RA SGLT-2i a large unselected cohort patients with type 2 diabetes resident Lombardy from 2015 2020.
To describe trends in diagnosed diabetes prevalence, incidence and mortality from 2000 to 2007 the most heavily populated Italian region.We examined prevalence rates of Type 1 2 yearly among individuals with using an administrative health database prescription, disease-specific exemption hospitalization records more than 9 million inhabitants Lombardy. Age- sex-specific were calculated temporal for subjects aged ≥ 30 years analysed.The crude point rose 3.0% 4.2% 2007, a 40% increase. The...
ABSTRACT Objective To investigate the prescribing patterns and prevalence of polypharmacy in community‐dwelling elderly people, to analyze association chronic medications number drug prescriptions with age sex. Methods All for people aged 65 years or older reimbursed by Italian National Health Service (NHS) dispensed retail pharmacies 15 local health units (LHU) Lombardy Region during 2005 were analyzed. Logistic regression analysis was used assess between prescription (overall, drugs,...
Abstract Background Diabetes mellitus (DM) is associated with an increased mortality risk in patients hospitalized acute myocardial infarction (AMI); however, no studies have investigated the impact of duration DM on in-hospital mortality. In this study, we evaluated AMI according to status and its duration. Methods Using health administrative databases Lombardy, patients≥50 years from 2010 2019 were included analysis stratified DM: <5, 5–10, > 10 years. The primary endpoint was during...
Abstract Background Lombardy was affected in the early months of 2020 by SARS‐CoV‐2 pandemic with very high morbidity and mortality. The post‐COVID‐19 condition related public health burden are scarcely known. Setting design Using regional population administrative database including all 48,932 individuals who survived COVID‐19 became polymerase‐chain‐reaction negative for 31 May 2020, incident mortality, rehospitalizations, attendances to hospital emergency room, outpatient medical visits...
Predictors of coronavirus disease 2019 (COVID-19)-related rehospitalization remain underexplored. This study aims to identify the main risk factors associated with rehospitalizations due severe acute respiratory syndrome 2 (SARS-CoV-2) reinfections among residents Lombardy, northern Italy. A retrospective observational was conducted using two linked administrative databases covering demographic data, comorbidities, hospital records, and COVID-19 data Lombardy residents. The population...
Abstract Background While risk factors for COVID-19 hospitalization are well characterized, only a few studies investigated those associated with hospital re-admission after SARS-CoV-2 re-infections, since most focused-on because of all-causes. Our aim was to identify co-morbidities and other second hospitalization. Study flowchart timeline Methods Administrative database from the Lombardy Welfare Directorate used detect patients hospitalized first time between 1st Feb 2020 31st Aug 2021....
Abstract Background Functional decline (decrement in physical/cognitive functioning that causes inability to engage daily activities) is common following acute hospitalization elderly patients and associated with hospital readmission, institutionalization, mortality. We sought determine rate of institutionalization after COVID-19 characterize functional institutionalized COVID-19. Characteristics pre-COVID-19 hospitalized Methods conducted a retrospective cohort study using health...
Abstract: Several laboratories have reported a lack of protein kinase C (PKC) activation in response to various stimuli the brain aged rats. It has been suggested that changes lipid membrane composition could be related this functional deficit. However, recent evidence indicated translocation PKC different subcellular compartments is controlled by protein‐protein interactions. Recently, class proteins, termed receptors for activated (RACKs), described bind PKC. The present study was...
Administrative databases have become an important tool to monitor diseases. Patients with epilepsy could be traced using disease-specific codes and prescriptions, but formal validation is required obtain accurate case definition. The aim of the study was correlate administrative data on independent source patients in a district Lombardy, Northern Italy, from 2000 2008.Data nearly 320 600 inhabitants Lecco collected Drug Database Lombardy Region were analysed. Among them included who...
Purpose The purpose of this study is to explore the effect incident chronic polypharmacy on 1-year hospitalization, institutionalization, and mortality among older people evaluate whether or not differed according index year (2001 2009), sex, age. Methods Data were obtained from administrative database Lombardy region (Northern Italy). We compared community-dwelling elderly with an exposure (five more drugs during 1 month for at least 6 months in year) either 2009) exposed same years....
To estimate the rate of paediatric attendance at emergency departments (EDs) in Lombardy Region, Italy, and to determine factors contributing different patterns use.By analysing healthcare administrative databases, ED by 1.6 million youths <18 years old during 2012 Region was assessed. The pattern use categorised based on number visits level emergency, defined triage code outcome visit. Logistic regression analyses were performed identify characteristics access for non-urgent reasons those...
Biological drugs have improved the management of immune-mediated inflammatory diseases (IMIDs) despite being associated with important safety issues such as immunogenicity, infections, and malignancies in real-world settings.The aim this study was to explore potential a large Italian multi-database distributed network for use postmarketing surveillance biological drugs, including biosimilars, patients IMID.A retrospective cohort conducted using 13 regional claims databases during 2010-2019....
To compare the association of metformin use and coronavirus disease 2019 (COVID-19) outcomes in a cohort 31 966 patients with diabetes Lombardy.We used COVID-19 linkable administrative regional database to select who were aged 40 years or older. They had at least two prescriptions antidiabetic drugs positive test for severe acute respiratory syndrome coronavirus-2 from 15 February 2020 March 2021. The clinical was assessed by multivariable logistic regression analyses after propensity score...
Poor medication adherence compromises treatment efficacy and adversely affects patients' clinical outcomes. This study aims to assess (1) multiple the most common drug classes chronically prescribed older people, (2) factors associated, (3) retrospective cohort included 122,655 community-dwelling patients aged 65-94 years old, newly exposed chronic polypharmacy, recorded in Lombardy Region (northern Italy) administrative database from 2016 2018. Multiple was assessed for drugs diabetes,...