A5001900667- Diabetes Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Pancreatitis Pathology and Treatment
- Metabolism, Diabetes, and Cancer
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Heart Failure Treatment and Management
- Consumer Attitudes and Food Labeling
- COVID-19 and Mental Health
- Pharmaceutical Economics and Policy
- Child Nutrition and Water Access
- Peripheral Artery Disease Management
- Acute Ischemic Stroke Management
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
Mario Negri Institute for Pharmacological Research
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
A polypill that includes key medications associated with improved outcomes (aspirin, angiotensin-converting-enzyme [ACE] inhibitor, and statin) has been proposed as a simple approach to the secondary prevention of cardiovascular death complications after myocardial infarction.In this phase 3, randomized, controlled clinical trial, we assigned patients infarction within previous 6 months polypill-based strategy or usual care. The treatment consisted aspirin (100 mg), ramipril (2.5, 5, 10...
GLP-1 receptor agonists (GLP-1 RA) and SGLT-2 inhibitors (SGLT-2i) have shown to reduce the risk of major adverse cardiovascular events (MACE), death worsening nephropathy when added standard care. However, these two dug classes differ in efficacy safety. We compared effectiveness safety profile RA SGLT-2i a large unselected cohort patients with type 2 diabetes resident Lombardy from 2015 2020.
Abstract Background Diabetes mellitus (DM) is associated with an increased mortality risk in patients hospitalized acute myocardial infarction (AMI); however, no studies have investigated the impact of duration DM on in-hospital mortality. In this study, we evaluated AMI according to status and its duration. Methods Using health administrative databases Lombardy, patients≥50 years from 2010 2019 were included analysis stratified DM: <5, 5–10, > 10 years. The primary endpoint was during...
<sec> <title>UNSTRUCTURED</title> Background: Chronic kidney disease (CKD) is characterized by long-term structural or functional abnormalities, often progressing over decades and potentially leading to failure, treatable only dialysis transplantation. Nutritional, physical activity mindfulness programs can play a key role in conservative CKD management, aiming slow the progression of symptoms, decrease drug load, reduce stress delay dialysis. KidneYou integrates nutrition, exercise, improve...
To compare the association of metformin use and coronavirus disease 2019 (COVID-19) outcomes in a cohort 31 966 patients with diabetes Lombardy.We used COVID-19 linkable administrative regional database to select who were aged 40 years or older. They had at least two prescriptions antidiabetic drugs positive test for severe acute respiratory syndrome coronavirus-2 from 15 February 2020 March 2021. The clinical was assessed by multivariable logistic regression analyses after propensity score...
Background: Despite all the progress in management of acute COVID-19, it is still not clear why some people continue to experience symptoms after recovery. Using data from a self-administered online survey, we assessed prevalence and predictors post-acute COVID-19 an unselected population followed by GPs. Methods: Patients ≥18 years with confirmed diagnosis were included. The survey collected information on demographics, risk factors, course symptomatology. Fatigue Quality Life...
Data on the impact of liver disease (LD) in patients with atrial fibrillation (AF) and role oral anticoagulant (OAC) drugs for stroke prevention are limited.A retrospective observational population-based cohort study administrative health databases Lombardy region Italy. All AF ≥40 years admitted to hospital from 2000 2018 were considered. Atrial LD diagnosis established using ICD9-CM codes. Use OAC was determined Anatomical Therapeutic Chemical Primary outcomes stroke, major bleeding,...
Introduction Prevention of cardiovascular disease (CVD) is key importance in reducing morbidity, disability and mortality worldwide. Observational studies suggest that digital health interventions can be an effective strategy to reduce (CV) risk. However, evidence from large randomised clinical trials lacking. Methods analysis The CV-PREVITAL study a multicentre, prospective, randomised, controlled, open-label interventional trial designed compare the effectiveness educational motivational...
<sec> <title>BACKGROUND</title> Childhood obesity has become a significant public health concern over the past 2 decades, posing multifactorial challenges, including modifiable factors like dietary habits, physical activity, screen time, and sleeping habits. Prevention efforts require comprehensive approach comprising educational interventions, collaboration among multidisciplinary teams, community engagement. Since schools play central role in children's lives, they are ideal setting for...
Childhood obesity has become a significant public health concern over the past 2 decades, posing multifactorial challenges, including modifiable factors like dietary habits, physical activity, screen time, and sleeping habits. Prevention efforts require comprehensive approach comprising educational interventions, collaboration among multidisciplinary teams, community engagement. Since schools play central role in children's lives, they are ideal setting for promoting healthy
COVID-19 has been associated with a higher risk of post-acute complications. Our aim was to analyze and compare cardiovascular complications survivors the first second/third pandemic waves in Lombardy, both hospitalized non-hospitalized patients.We included adults aged ≥40 years infected during pandemic. The follow-up initiated 30 days after diagnosis continued up 9 months. Hazard ratios (HRs) 95% confidence intervals (CIs) outcomes were calculated against an inverse probability treatment...
Abstract Aims Data on the impact of liver disease (LD) in patients with atrial fibrillation (AF) and role oral anticoagulant (OAC) drugs for stroke prevention, are limited. We analysed LD OAC treatment determining stroke, major bleeding, all-cause death secondary bleeding outcomes. Methods A retrospective observational population-based cohort study. The study is derived from administrative health databases Lombardy region (&gt;10 million inhabitants), Italy. All AF ≥40 years admitted to...