A5027238188- Telomeres, Telomerase, and Senescence
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- 14-3-3 protein interactions
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Pharmaceutical studies and practices
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Amino Acid Enzymes and Metabolism
- Nutrition, Genetics, and Disease
- Dietary Effects on Health
- Folate and B Vitamins Research
- Peptidase Inhibition and Analysis
- Neuroscience and Neuropharmacology Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Protein Tyrosine Phosphatases
- Animal Nutrition and Physiology
- Genetic Associations and Epidemiology
- Mast cells and histamine
- Heme Oxygenase-1 and Carbon Monoxide
- Medication Adherence and Compliance
- Laser Applications in Dentistry and Medicine
- Chronic Kidney Disease and Diabetes
Charité - Universitätsmedizin Berlin
2015-2022
German Centre for Cardiovascular Research
2022
Berlin-Brandenburger Centrum für Regenerative Therapien
2018-2020
Humboldt-Universität zu Berlin
2018
Freie Universität Berlin
2018
Probiodrug (Germany)
2003-2017
QPS (Austria)
2017
Fraunhofer Institute for Cell Therapy and Immunology
2017
Wake Forest University
2015
A polypill that includes key medications associated with improved outcomes (aspirin, angiotensin-converting-enzyme [ACE] inhibitor, and statin) has been proposed as a simple approach to the secondary prevention of cardiovascular death complications after myocardial infarction.In this phase 3, randomized, controlled clinical trial, we assigned patients infarction within previous 6 months polypill-based strategy or usual care. The treatment consisted aspirin (100 mg), ramipril (2.5, 5, 10...
DNA methylation age (DNAm age; "epigenetic clock") has recently been described as highly correlated with chronological age. Several studies suggest that DNAm reflects, at least in part, biological Here, we adapted a published methylation-sensitive single nucleotide primer extension method for epigenetic estimation and calculated the based on only seven cytosine-phosphate-guanine sites 1,895 samples of Berlin Aging Study II. In second step, explored relationship between this new potential...
Abstract Aims Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystem disease. Evidence for disturbed vascular regulation comes from various studies showing cerebral hypoperfusion and orthostatic intolerance. The peripheral endothelial dysfunction (ED) has not been sufficiently investigated in patients with ME/CFS. aim of the present study was to examine function Methods results Thirty‐five [median age 40 (range 18–70) years, mean body mass index 23.8 ± 4.2 kg/m...
Numerous studies suggest that the majority of amyloid-<i>β</i> (A<i>β</i>) peptides deposited in Alzheimer's disease (AD) are truncated and post-translationally modified at N terminus. Among these species, pyroglutamyl-A<i>β</i> (pE-A<i>β</i>, including N3pE-A<i>β</i>40/42 N11pE-A<i>β</i>40/42) has been identified as particularly neurotoxic. The N-terminal modification renders peptide hydrophobic, accelerates formation oligomers, reduces degradation by peptidases, leading ultimately to...
Physical activity and sports have repeatedly been reported to be associated with telomere length. We studied the association of different types across stages life on relative leukocyte length (rLTL) in advanced age.815 participants (397 men) from Berlin Aging Study II aged over 61 years were included analysis. rLTL was measured by real time PCR physical determined retrospectively questionnaire, assessing type duration past as well currently. Five separate multiple linear regression models...
Pyroglutamate-amyloid-β (pE-Aβ) peptides are major components of Aβ-oligomers and Aβ-plaques, which regarded as key culprits Alzheimer's disease (AD) pathology. PQ912 is a competitive inhibitor the enzyme glutaminyl cyclase (QC), essential for formation pE-Aβ peptides.A randomized, double-blind, placebo-controlled, single- multiple-ascending oral dose study investigated safety, pharmacokinetics, pharmacodynamics in healthy nonelderly elderly subjects.PQ912 was considered safe well tolerated...
Pyroglutamylation of truncated Aβ peptides, which is catalysed by enzyme glutaminyl cyclase (QC), generates pE-Aβ species with enhanced aggregation propensities and resistance to most amino-peptidases endo-peptidases. have been identified as major constituents plaques reduction associated improvement cognitive tasks in animal models Alzheimer's disease (AD). Pharmacological inhibition QC has thus emerged a promising therapeutic approach for AD. Here, we question whether cerebrospinal fluid...
<b><i>Background:</i></b> The length of the chromosome ends, telomeres, is widely accepted as a biomarker aging. However, dynamic relationship between telomere and hematopoietic parameters in normal aging process, which particular interest with respect to age-related anemia, not well understood. <b><i>Objective:</i></b> We have analyzed relative leukocyte (rLTL) several hematological older group Berlin Aging Study II (BASE-II) participants....
Selected nutrients or food groups have often been studied with regard to long-term mortality and cardiovascular disease, whereas the relation between diet quality appendicular lean mass (ALM) has rarely researched. The aim of this study was explore association a Mediterranean-style ALM in community-dwelling older people. Cross-sectional data from Berlin Aging Study II were available for 1,509 participants (51% women, 68.2±3.7 years). Nutrient intake assessed using European Prospective...
Abstract Background Elevated brain levels of the pleiotropic cytokine interleukin-6, which is mainly secreted from activated local astrocytes, contribute to pathological events including neuroinflammation and neurodegeneration. Thus, inhibition IL-6 expression provides a rationale strategy for targeting onset or further progression neurological disorders Alzheimer's disease, multiple sclerosis, Parkinson's disease traumatic injury. The purpose this study was identify characterize new potent...
Body mass index (BMI), bone mineral density (BMD), and telomere length are phenotypes that modulate the course of aging. Over 40% their phenotypic variance is determined by genetics. Genome-wide association studies (GWAS) have recently uncovered >100 independent single-nucleotide polymorphisms (SNPs) showing genome-wide significant (p < 5 × 10-8) with these traits.To test individual combined impact previously reported GWAS SNPs on BMI, BMD, relative leukocyte (rLTL) in ∼1,750 participants...
Targeting drugs or prodrugs to a specific enzyme by simultaneously targeting cell membrane carriers for efficient transport should provide the highest bioavailability along with specificity at site of action. The peptide transporters PEPT1 and PEPT2 are expressed in variety tissues, including brush-border membranes epithelial cells small intestine kidney. accept wide range substrates therefore good targets transporter-mediated drug delivery. Here, we report screening procedure peptidomimetic...
The aim of this study was to investigate the effect long-term treatment with dipeptidyl peptidase inhibitor P32/98 and its combination rosiglitazone on blood glucose control islet Langerhans histology in male Zucker diabetic fatty (ZDF) rats, when begins before or after development overt diabetes.ZDF rats were treated from age 9, 12 15 weeks. Rosiglitazone maleate given a separate group 13 all these rosiglitazone-treated 16 weeks age. also half that 9 compounds by oral gavage until 14 old...
infiltration in the major salivary glands (parotid, submandibular and sublingual glands).Male C57BL/6 mice were bred for 2 years under SPF condition.To examine effect of JTT, feed with/without JTT was given to mice.Salivary dissected processed histological examination.Histological examination clearly indicated severe lymphocyte parotid glands, but not control mice.Histomorphometric analysis that degree 4.35 ± 1.67% 8.58 4.43 % respectively.On other hand, ratio reduced 1.94 1.10 1.74 0.59...
N-terminally truncated and pyroglutamate (pE)-modified Aβ peptides appear to be an important mediator of the Aβ-dependent cytotoxicity occurring in AD. In vivo, formation pE-Aβ is catalyzed by glutaminyl cyclase (QC), suggesting that inhibition QC brain represents new therapeutic target. PQ912 first a series orally available, small molecule inhibitors being developed for treatment Following single multiple dose administration study healthy young subjects (Weber et al, AD/PD 2013), this...