A5039020844- Atherosclerosis and Cardiovascular Diseases
- Genetic Associations and Epidemiology
- Nuclear Receptors and Signaling
- Single-cell and spatial transcriptomics
- Protease and Inhibitor Mechanisms
- RNA Research and Splicing
- HIV-related health complications and treatments
- RNA modifications and cancer
- Immune cells in cancer
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Angiogenesis and VEGF in Cancer
- Phagocytosis and Immune Regulation
- Kruppel-like factors research
- HIV/AIDS Research and Interventions
- Genomic variations and chromosomal abnormalities
- Cancer-related gene regulation
- Cardiovascular Disease and Adiposity
- Alcohol Consumption and Health Effects
- Medication Adherence and Compliance
- Renal and related cancers
- HIV Research and Treatment
- Heart Failure Treatment and Management
- Clusterin in disease pathology
- T-cell and B-cell Immunology
ENOES
2024-2025
Institut de Physique Théorique
2024-2025
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2024-2025
Centre National de la Recherche Scientifique
2024-2025
Cardiovascular Institute of the South
2024
Stanford University
2021-2024
Oklahoma State University
2023
Hospital General Universitario de Alicante Doctor Balmis
2017-2022
Servicio Gallego de Salud
2018-2021
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2017-2019
A polypill that includes key medications associated with improved outcomes (aspirin, angiotensin-converting-enzyme [ACE] inhibitor, and statin) has been proposed as a simple approach to the secondary prevention of cardiovascular death complications after myocardial infarction.In this phase 3, randomized, controlled clinical trial, we assigned patients infarction within previous 6 months polypill-based strategy or usual care. The treatment consisted aspirin (100 mg), ramipril (2.5, 5, 10...
We have previously shown that polygenic risk scores (PRS) can improve stratification of peripheral artery disease (PAD) in a large, retrospective cohort. Here, we evaluate the potential PRS improving detection PAD and prediction major adverse cardiovascular cerebrovascular events (MACCE) (AE) an institutional patient created cohort 278 patients (52 cases 226 controls) fit PAD-specific based on weighted sum alleles. built traditional clinical models machine learning (ML) using genetic...
Neuropilin-1 is henceforth a relevant target in cancer treatment; however, its way of action remains partly elusive, and the development small inhibitory molecules therefore required for study. Here, we report that two small-sized neuropilin antagonists (NRPa-47 NRPa-48), VEGF-A165/NRP-1 binding inhibitors, are able to decrease VEGF-Rs phosphorylation modulate their downstream cascades triple-negative breast cell line (MDA-MB-231). Nevertheless, NRPas exert divergent pathway regulation MAPK...
Atherosclerosis is an inflammatory disorder responsible for cardiovascular disease. Reactivation of efferocytosis, the phagocytic removal cells by macrophages, has emerged as a translational target atherosclerosis. Systemic blockade key 'don't-eat-me' molecule, CD47, triggers engulfment apoptotic vascular tissue and potently reduces plaque burden. However, it also induces red blood cell clearance, leading to anemia. To overcome this, we previously developed macrophage-specific nanotherapy...
The reported prevalence of HIV-associated neurocognitive disorders in HIV people depends on the population studied and methodology used. We analyze impairment (NCI) associated factors patients successful antiretroviral therapy (ART), without comorbidities. Cross-sectional observational study subjects, ≥18 years old, stable ART, viral load <50 copies/mL. Patients with medical or psychiatric comorbidities substance abuse were excluded. NCI was diagnosed using Frascati criteria, examining seven...
Abstract Background Pathogenesis of atherosclerosis is complex, and differences between HIV ‐infected patients general population cannot be completely explained by the higher prevalence traditional cardiovascular risk factors. We aimed to analyse association inflammation subclinical in with low Framingham score. Materials methods Case–control study. Setting: Outpatient Infectious Diseases clinic a university hospital. Subjects: ‐1‐infected aged > 35 years receiving antiretroviral...
The journey of drug discovery (DD) has evolved from ancient practices to modern technology-driven approaches, with Artificial Intelligence (AI) emerging as a pivotal force in streamlining and accelerating the process. Despite vital importance DD, it faces challenges such high costs lengthy timelines. This review examines historical progression current market DD alongside development integration AI technologies. We analyse encountered applying focusing on design protein–protein interactions....
Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWASs, and the causal gene-regulatory mechanisms these during atherosclerosis remain unclear. We incorporated local ancestry haplotypes to identify quantitative trait expression (eQTLs) splicing (sQTLs) arteries from 138 ancestrally diverse Americans. Of 2,132 eQTL-associated genes (eGenes), 47% were previously unreported...
Genome-wide association studies (GWAS) have identified hundreds of genetic risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWAS and the causal gene-regulatory mechanisms these during atherosclerosis remain unclear. We incorporated local ancestry haplotype information to identify quantitative trait (QTL) gene expression splicing arteries obtained from 138 ancestrally diverse Americans. Of 2,132 eQTL-associated genes (eGenes), 47% were...
Smooth muscle cell (SMC) plasticity and phenotypic switching play prominent roles in the pathogenesis of multiple diseases, but their role tumorigenesis is unknown. We investigated whether how SMC diversity plays a tumor angiogenesis microenvironment.
Smooth muscle cell (SMC) plasticity plays a prominent role in the pathogenesis of multiple diseases. This phenomenon is characterized by loss canonical SMC marker gene expression (such as Acta2 and Myh11), increased proliferation migration, upregulation genes typically associated with other types, such macrophages [1-3]. process best described atherosclerosis, where phenotype switching, clonal expansion, aberrant inflammatory matrix proteins contribute to lesion progression plaque...
Abstract Coronary artery disease (CAD) is a complex inflammatory involving genetic influences across several cell types. Genome-wide association studies (GWAS) have identified over 170 loci associated with CAD, where the majority of risk variants reside in noncoding DNA sequences impacting cis -regulatory elements (CREs). Here, we applied single-cell ATAC-seq to profile 28,316 cells coronary segments from 41 patients varying stages which revealed 14 distinct cellular clusters. We mapped...
Competitive exclusion (CE) bacteria have been used to control the colonization of chickens by major foodborne pathogens. In this article, we report draft whole-genome sequences three Ligilactobacillus salivarius strains isolated from chicken gastrointestinal tracts and previously selected as CE for poultry. These genome will provide a foundation further characterization understanding their attributes.
It is increasingly clear that cardiovascular disease and cancer have shared pathophysiological mechanisms beyond traditional risk factors. Murine models demonstrated tumors grow more quickly in the presence of abnormalities, targeting signaling pathways has proven efficacious both diseases. unknown, however, if smooth muscle cell (SMC) plasticity as seen atherogenesis represents yet another biologic parallel. Our aim was to understand SMC occurs tumor vasculature, how those transitions are...
Bacillus species have been widely selected and used as probiotics for humans animals. In this article, we reported draft whole-genome sequences of four strains isolated from sourdough chicken cecum previously potential poultry. These genome will provide a foundation further characterization understanding their probiotic attributes.