A5071410360- Alzheimer's disease research and treatments
- Protease and Inhibitor Mechanisms
- 14-3-3 protein interactions
- Prion Diseases and Protein Misfolding
- Angiogenesis and VEGF in Cancer
- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Cell Adhesion Molecules Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Clusterin in disease pathology
- Barrier Structure and Function Studies
- CRISPR and Genetic Engineering
- Epilepsy research and treatment
- Axon Guidance and Neuronal Signaling
- Pluripotent Stem Cells Research
- Drug Transport and Resistance Mechanisms
- Lymphatic System and Diseases
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2015-2020
CEA Paris-Saclay
2018-2020
Université Paris-Saclay
2018-2020
Mère et Enfant en Milieu Tropical
2019
Infectious Disease Models and Innovative Therapies
2015
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2015
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques
2014
Centre National de la Recherche Scientifique
2014
Sorbonne Paris Cité
2014
Université Paris Cité
2014
Human mini-brains (MB) are cerebral organoids that recapitulate in part the complexity of human brain a unique three-dimensional vitro model, yielding discrete regions reminiscent cortex. Specific proteins linked to neurodegenerative disorders physiologically expressed MBs, such as APP-derived amyloids (Aβ), whose physiological and pathological roles interactions with other not well established humans. Here, we demonstrate neuroectodermal can be used study Aβ accumulation implicated...
Abstract The development of effective central nervous system (CNS) drugs has been hampered by the lack robust strategies to mimic blood-brain barrier (BBB) and cerebrovascular impairments in vitro . Recent technological advancements BBB modeling using induced pluripotent stem cells (iPSCs) allowed overcome some these obstacles, nonetheless pertinence for their use drug permeation study remains be established. This mandatory information requires a cross comparison vivo pharmacokinetic data...
Neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are characterized by increased protein aggregation in the brain, progressive neuronal loss, inflammation, neurogenesis impairment. We analyzed effects of a new purine derivative drug, PDD005, attenuating mechanisms involved pathogenesis neurodegenerative using both vivo vitro models. show that PDD005 is distributed to brain can rescue cognitive deficits associated with aging mice. Treatment prevents impairment...
Human brain organoids (mini-brains) consist of self-organized three-dimensional (3D) neural tissue which can be derived from reprogrammed adult cells and maintained for months in culture. These 3D structures manifest substantial potential the modeling neurodegenerative diseases pave way personalized medicine. However, as these models express whole human genetic complexity, it is critical to have access isogenic mini-brains that only differ specific controlled variables. Genetic engineering...
An amendment to this paper has been published and can be accessed via a link at the top of paper.