A5017420618- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Mesenchymal stem cell research
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
- Pericarditis and Cardiac Tamponade
- Cardiomyopathy and Myosin Studies
- Aortic Disease and Treatment Approaches
- Artificial Intelligence in Healthcare and Education
- Health Systems, Economic Evaluations, Quality of Life
- Advanced MRI Techniques and Applications
- Pulmonary Hypertension Research and Treatments
Centro de Investigación Biomédica en Red
2017-2025
Universidad de Salamanca
2016-2025
Instituto de Investigación Biomédica de Salamanca
2016-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2025
Instituto de Salud Carlos III
2017-2025
Complejo Hospitalario de Salamanca
2016-2025
Hospital Universitario Reina Sofía
2023-2025
University College London
2025
Hospital General Universitario Gregorio Marañón
2008-2024
University of Georgia
2022-2024
Bone marrow mononuclear cells (BMCs) from 20 patients with extensive reperfused myocardial infarction (MI) were used to assess their regenerative capability “in vitro” and effect on postinfarction left ventricular (LV) remodeling. Human BMCs labeled, seeded top of cryoinjured mice heart slices, cultured. showed tropism for ability graft into the damaged mouse cardiac tissue and, after 1 week, acquired a cardiomyocyte phenotype expressed proteins, including connexin43. In clinical trial,...
A polypill that includes key medications associated with improved outcomes (aspirin, angiotensin-converting-enzyme [ACE] inhibitor, and statin) has been proposed as a simple approach to the secondary prevention of cardiovascular death complications after myocardial infarction.In this phase 3, randomized, controlled clinical trial, we assigned patients infarction within previous 6 months polypill-based strategy or usual care. The treatment consisted aspirin (100 mg), ramipril (2.5, 5, 10...
Anthracycline-induced cardiotoxicity is a major clinical problem, and early markers are needed. The purpose of this study was to identify doxorubicin-induced by serial multiparametric cardiac magnetic resonance (CMR) its pathological correlates in large animal model. Twenty pigs were included. Of these, 5 received biweekly intracoronary doxorubicin doses (0.45 mg/kg/injection) followed until sacrifice at 16 weeks. Another 3 A third group sacrificed after the dose. All groups underwent weekly...
We aimed to determine whether treatment with sildenafil improves outcomes of patients persistent pulmonary hypertension (PH) after correction valvular heart disease (VHD).
Background— Percutaneous transcatheter closure of patent foramen ovale (PFO) is used as an alternative to surgery or long-term anticoagulation for the treatment patients with paradoxical embolism and PFO. Methods Results— We report immediate clinical echocardiographic outcome 110 consecutive (58 males, mean age 47±14 years) who underwent PFO because between 1995 2001. Procedural success, defined successful deployment device effective occlusion (no, trivial, shunt after placement), was...
Percutaneous mitral balloon valvuloplasty (PMV) results in good immediate results, particularly patients with echocardiographic scores (Echo-Sc) < or =8. However, which variables relate to long-term outcome is unclear.We report the and clinical follow-up (mean, 4.2+/-3.7 years; range, 0.5 15) of 879 who underwent 939 PMV procedures. Patients were divided into 2 groups, Echo-Sc =8 (n=601) >8 (n=278). resulted an increase valve area from 1.0+/-0.3 2.0+/-0.6 cm2 0.8+/-0.3 1.6+/-0.6 (P<0.0001)....
In patients with acute myocardial infarction and ST-segment elevation (STEMI), primary angioplasty is frequently not available or performed beyond the recommended time limit. We designed a non-inferiority, randomized, controlled study to evaluate whether lytic-based early routine represents reasonable reperfusion option for victims of STEMI irrespective geographic logistical barriers.A total 212 were randomized full tenecteplase followed by stenting within 3-12 h randomization (early...
Clinical protocols aimed to characterize the post-myocardial infarction (MI) heart by cardiac magnetic resonance (CMR) need be standardized take account of dynamic biological phenomena evolving early after index ischemic event. Here, we evaluated time course edema reaction in patients with ST-segment-elevation MI CMR and assessed its implications for myocardium-at-risk (MaR) quantification both a large-animal model.A total 16 anterior successfully treated primary angioplasty matched controls...
The metaverse, a rapidly evolving research area, is virtual, interconnected universe that seamlessly integrates digital and physical realms, facilitating immersive experiences, social interaction, economic activities across various fields, including computer science, business, education. Despite its potential to transform current pedagogies learning experiences through engaging, interactive, fascinating educational techniques, limited in exploring application, usability, user experience,...
A simple and fast high performance liquid chromatographic method for five catechins caffeine using an ODS column a water-acetonitrile-formic acid mobile phase system was developed. The (epicatechin, catechin, epigallocatechin, epigallocatechin gallate, epicatechin gallate) were separated by acetonitrile gradient within 20 min. detection limit of the approximately 10 ng all compounds (by injecting microL). Several green, black instant teas analysed this method. By studied as chemical...
The impact of cardioprotective strategies and ischemia duration on postischemia/reperfusion (I/R) myocardial tissue composition (edema, myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, microvascular obstruction) is not well understood.To study the effect protective interventions temporal dynamics in a translational animal model I/R by use state-of-the-art imaging technology.Four 5-pig groups underwent different protocols: 40-minute (prolonged ischemia, controls),...
Rationale: Allogeneic cardiac stem cells (AlloCSC-01) have shown protective, immunoregulatory, and regenerative properties with a robust safety profile in large animal models of heart disease. Objective: To investigate the feasibility early administration AlloCSC-01 patients ST-segment–elevation myocardial infarction. Methods Results: CAREMI (Safety Efficacy Intracoronary Infusion Human Cardiac Stem Cells Patients With STEMI Left Ventricular Dysfunction) was phase I/II multicenter,...
Abstract Background Cardiac sequelae of past SARS-CoV-2 infection are still poorly documented. We conducted a cross-sectional study in health-care workers to report evidence pericarditis and myocarditis after infection. Methods studied 139 with confirmed (103 diagnosed by RT-PCR 36 serology). Participants underwent clinical assessment, electrocardiography, laboratory tests including immune cell profiling cardiac magnetic resonance (CMR). Pericarditis was when classical criteria were present,...
Abstract Aims Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC. Methods and results Forty Large-White pigs were included. In Study 1, 20 randomized 1:1 remote ischaemic preconditioning (RIPC, 3 cycles 5 min leg ischaemia followed by reperfusion) or pretreatment. RIPC was performed immediately before...
Same-day discharge (SDD) is feasible after pulmonary vein isolation (PVI). We aim to compare prospectively cryoballoon (CRYO) vs. radiofrequency (RF) ablation in a systematic SDD programme.We analysed the 617 scheduled PVI performed consecutively at our institution (n = 377 CRYO, n 240 RF) from 1 April 2019 31 December 2022 within programme of SDD. The feasibility SDD, 10-day incidence urgent/unplanned medical care (UUC-10), and cost per procedure due hospital resource use were studied. 100...
The contents of gallic acid, epigallocatechin gallate, epigallocatechin, epicatechin, epicatechin catechin, caffeine, theophylline, and theobromine were determined in a set 45 tea samples, including fermented (black red) nonfermented (green) teas different geographical origins (i.e., China, Japan, Kenya, Sri Lanka, India). A reversed-phase high performance liquid chromatographic method with gradient elution photometric detection at 275 nm was used to carry out the analysis. Before HPLC...