A5063767504- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Coronary Interventions and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Advanced X-ray and CT Imaging
- Infective Endocarditis Diagnosis and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac tumors and thrombi
- Aortic Disease and Treatment Approaches
- Coronary Artery Anomalies
- Viral Infections and Immunology Research
- Holomorphic and Operator Theory
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
Cardiovascular Institute of the South
2013-2024
Icahn School of Medicine at Mount Sinai
2015-2024
Spanish National Centre for Cardiovascular Research
2014-2024
Mount Sinai Hospital
2008-2024
Mount Sinai Hospital
2009-2024
Mount Sinai Health System
2024
University of California, Irvine
2024
Hospital Del Mar
2023
Parc de Salut
2016-2023
Universitat Pompeu Fabra
2016-2023
Absence of cardiovascular risk factors (CVRFs) is traditionally considered low for atherosclerosis; however, individuals without CVRFs, as currently defined, still have events.This study sought to identify predictors subclinical atherosclerosis in CVRF-free individuals.Participants from the PESA (Progression Early Subclinical Atherosclerosis) (n = 4,184) conventional CVRFs were evaluated 1,779; 45.0 ± 4.1 years, 50.3% women). CVRF freedom was defined no current smoking and untreated blood...
<h3>Objective</h3> To quantify right ventriculo-arterial coupling in pulmonary hypertension by combining standard heart catheterisation (RHC) and cardiac magnetic resonance (CMR) to estimate it non-invasively with CMR alone. <h3>Design</h3> Cross-sectional analysis a retrospective cohort of consecutive patients. <h3>Setting</h3> Tertiary care centre. <h3>Patients</h3> 139 adults referred for evaluation. <h3>Interventions</h3> RHC within 2 days (n=151 test pairs). <h3>Main outcome...
Even when low-density lipoprotein-cholesterol (LDL-C) levels are lower than guideline thresholds, a residual risk of atherosclerosis remains. It is unknown whether triglyceride (TG) associated with subclinical and vascular inflammation regardless LDL-C. This study sought to assess the association between serum TG early in apparently healthy individuals. An observational, longitudinal, prospective cohort study, including 3,754 middle-aged individuals low moderate cardiovascular from PESA...
It is assumed that the survival factors Bcl-2 and Bcl-xL are mainly functional on mitochondria therefore must contain mitochondrial targeting sequences. Here we show, however, only specifically targeted to outer membrane (MOM) whereas distributes several intracellular membranes. Mitochondrial of requires COOH-terminal transmembrane (TM) domain flanked at both ends by least two basic amino acids. This sequence a bona fide signal for MOM as it confers specific localization soluble EGFP. The...
To retrospectively identify pulmonary arterial (PA) flow parameters measured with phase-contrast magnetic resonance (MR) imaging that allow noninvasive diagnosis of chronic PA hypertension (PAH).The study was HIPAA compliant and approved by the institutional review board; a waiver informed consent obtained. Fifty-nine patients (49 female patients; mean age, 46 years; range, 16-85 years) known to have or suspected having PAH underwent breath-hold MR right-sided heart catheterization (RHC)....
Beta-blockers improve clinical outcome when administered early after acute myocardial infarction. However, whether beta-blockers actually reduce the infarction size is still in dispute. Cardiac magnetic resonance imaging can accurately depict left ventricular (LV) ischemic myocardium at risk (T2-weighted hyperintense region) infarction, as well extent of necrosis (delayed gadolinium enhancement). The aim this study was to determine administration metoprolol could increase salvage, measured...
Fingolimod, a sphingosine-1-phosphate receptor agonist, is used for the treatment of multiple sclerosis and exerts antiapoptotic properties. We hypothesized that activation with fingolimod during acute myocardial infarction (MI) inhibits apoptosis, leading to increased salvage, reduced infarct size, mitigated left ventricular (LV) remodeling in porcine model ischemia/reperfusion.Ischemia/reperfusion was induced pigs by balloon occlusion anterior descending artery, followed reperfusion....
Cyclin A2 mediates cardiac regeneration of infarcted porcine hearts.