A5007247112- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Issues in Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- Ultrasound in Clinical Applications
- Frailty in Older Adults
- COVID-19 Clinical Research Studies
- Cardiac Valve Diseases and Treatments
- Emergency and Acute Care Studies
- Cardiac pacing and defibrillation studies
- Nutrition and Health in Aging
- Cellular Mechanics and Interactions
- Diabetes Treatment and Management
- Hippo pathway signaling and YAP/TAZ
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Cardiac, Anesthesia and Surgical Outcomes
Northwell Health
2019-2025
Lenox Hill Hospital
2023-2025
North Shore University Hospital
2019-2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2019-2023
Rush University Medical Center
2021
Public Health England
2021
National Institute for Health Research
2021
University of Oxford
2021
University of Bristol
2021
Wayne State University
2021
Although furosemide is the most commonly used loop diuretic in patients with heart failure, some studies suggest a potential benefit for torsemide.To determine whether torsemide results decreased mortality compared among hospitalized failure.TRANSFORM-HF was an open-label, pragmatic randomized trial that recruited 2859 participants failure (regardless of ejection fraction) at 60 hospitals United States. Recruitment occurred from June 2018 through March 2022, follow-up 30 months death and 12...
The impact of COVID-19 on heart transplant (HTx) recipients remains unclear, particularly in the early post-transplant period.We share novel insights from our experience five HTx patients with (three within 2 months post-transplant) institution at epicenter pandemic.All exhibited moderate (requiring hospitalization, n = 3) or severe ICU and/or mechanical ventilation, 2) illness. Both cases illness were transplanted approximately 6 weeks before presentation and acquired through community...
Abstract ß/A4 peptides are known to induce neurodegeneration in cultures of rat brain cells and neural cell lines (Yankner et al: Science 250:279–282, 1990; Behl Biochem Biophys Res Commun 186:944–950, 1992). The current data show that these similar SH‐SY5Y neuroblastoma cells, extending characterization toxicity a human nerve line. Human respond aggregated with changes shape, membrane blebbing, antigenic modification, loss attachment the substrate, death. require aggregation for maximum...
Donation after Circulatory Death (DCD) is an alternative to Brain death (DBD), and a growing strategy for organ procurement in the United States(US). The purpose of this analysis was review number quality hearts one Network Organ Sharing (UNOS) Region that were not utilized as potential consequence nonheart DCD donation. We retrospectively identified all successful US solid donors from 1/2011 3/1/2017, defined ideal heart donor by age left ventricular ejection fraction (LVEF), then reviewed...
Heart failure exacerbations are a common cause of hospitalizations with high readmission rate. There few validated predictors after treatment for acute decompensated heart (ADHF). Lung ultrasound (LUS) is sensitive and specific in the assessment pulmonary congestion; however, it not frequently utilized to assess congestion before discharge. This study assessed association between number B-lines, on LUS, at patient discharge risk 30-day patients hospitalized (ADHF).This was single-center...
Loop diuretics are a primary therapy for the symptomatic treatment of heart failure (HF), but whether torsemide improves patient symptoms and quality life better than furosemide remains unknown. As prespecified secondary end points, TRANSFORM-HF trial (Torsemide Comparison With Furosemide Management Heart Failure) compared effect versus on patient-reported outcomes among patients with HF.
Expert opinion and professional society statements have called for multi-tier care systems the management of cardiogenic shock (CS). However, little is known about how to pragmatically define centers with different levels (LOC) CS.Eleven 23 hospitals within our healthcare system sharing a common electronic health record were classified as LOC according their highest mechanical circulatory support (MCS) capabilities: Level 1 (L-1)-durable left ventricular assist device, 1A...
Focal adhesion kinase (FAK) is a non-receptor protein tyrosine that appears to play central role in integrin-mediated signal transduction non-neuronal cells, linking the extracellular matrix actin-based cytoskeleton at focal contacts. Biochemical analysis has revealed presence of FAK immunoreactivity cells neuronal lineage (Zhang et al., 1994) and CNS (Burgaya al. 1995; Grant 1995). In current work, we have examined immunodistribution nerve cell cultures tissue sections from rat CNS....
Abstract Objective To detect and categorize time‐specific variations in daytime intraocular pressure (IOP) found Rhesus monkeys with laser‐induced ocular hypertension. Procedures Ten male argon hypertension one eye were anesthetized ketamine hydrochloride, the IOP measured both eyes at 7 a.m., 7.30 then hourly until 1 p.m. a Tonopen™ XL applanation tonometer. Intraocular time profiles for each animal developed. The means ± SD of IOPs calculated whole 6‐h study period, values compared...