A5054034179- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Transplantation: Methods and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Viral Infections and Immunology Research
- Cardiac electrophysiology and arrhythmias
- Sports injuries and prevention
- Cardiovascular and exercise physiology
- Cardiomyopathy and Myosin Studies
- Electrolyte and hormonal disorders
- Congenital Heart Disease Studies
- Cardiovascular Health and Risk Factors
- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Issues in Pregnancy
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Medication Adherence and Compliance
- Parathyroid Disorders and Treatments
Duke Medical Center
2008-2025
Duke University
2003-2024
Duke University Health System
2021-2024
University of California, Berkeley
2010-2024
Duke University Hospital
1998-2023
Johns Hopkins Medicine
2011-2022
Johns Hopkins University
2012-2022
Georgetown University
2008-2021
Institute of Cardiology
2021
Johns Hopkins Hospital
2011-2020
Patients with advanced heart failure have improved survival rates and quality of life when treated implanted pulsatile-flow left ventricular assist devices as compared medical therapy. New continuous-flow are smaller may be more durable than the devices.In this randomized trial, we enrolled patients who were ineligible for transplantation, in a 2:1 ratio, to undergo implantation device (134 patients) or currently approved (66 patients). The primary composite end point was, at 2 years, free...
The use of left ventricular assist devices is an accepted therapy for patients with refractory heart failure, but current pulsatile volume-displacement have limitations (including large pump size and limited long-term mechanical durability) that reduced widespread adoption this technology. Continuous-flow pumps are newer types developed to overcome some these limitations.In a prospective, multicenter study without concurrent control group, 133 end-stage failure who were on waiting list...
Nearly half of patients with heart failure have a preserved ejection fraction (HFpEF). Symptoms exercise intolerance and dyspnea are most often attributed to diastolic dysfunction; however, impaired systolic and/or arterial vasodilator reserve under stress could also play an important role.Patients HFpEF (n=17) control subjects without (n=19) generally matched for age, gender, hypertension, diabetes mellitus, obesity, the presence left ventricular hypertrophy underwent maximal-effort upright...
Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited cardiomyopathy characterized by dysfunction and arrhythmias. The purpose of our study was to describe the presentation, clinical features, survival, natural history ARVD in a large cohort patients from United States.The patient population included 100 (51 male; median age at 26 [interquartile range {IQR}, 18 38; range, 2 70] years). A familial pattern observed 32 patients. most common presenting symptoms were palpitations,...
Background— Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a progressive cardiomyopathy. We aimed to define long-term outcome in transatlantic cohort of 1001 individuals. Methods and Results— Clinical genetic characteristics follow-up data ARVD/C index-patients (n=439, fulfilling 2010 criteria all) family members (n=562) were assessed. Mutations identified 276 (63%). Index-patients presented predominantly with sustained arrhythmias (268; 61%). During median 7 years,...
Background— Right ventricular failure from increased pulmonary vascular loading is a major cause of morbidity and mortality, yet its modulation by disease remains poorly understood. We tested the hypotheses that, unlike systemic circulation, resistance (R PA ) compliance (C are consistently inversely related regardless age, hypertension, or interstitial fibrosis that this relation may be changed elevated capillary wedge pressure, augmenting right pulsatile load. Methods Results— Several...
Reduced kidney function is a risk factor for cardiovascular morbidity and mortality, both heart failure (HF) incidences are increasing. This study therefore sought to determine the effect of decreased on HF incidence in population-based middle-aged adults. From 1987 through 2002, 14,857 participants Atherosclerosis Risk Communities (ARIC) who were free prevalent at baseline followed incident hospitalization or death (International Classification Diseases, Ninth Revision/10th Revision...
We sought to determine the influence of genotype on clinical course and arrhythmic outcome among arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)-associated mutation carriers.Pathogenic mutations in desmosomal non-desmosomal genes were identified 577 patients (241 families) from USA Dutch ARVD/C cohorts. Patients with sudden cardiac death (SCD)/ventricular fibrillation (VF) at presentation (n = 36) younger (median 23 vs. 36 years; P < 0.001) than those presenting sustained...
The most advantageous combination of immunosuppressive agents for cardiac transplant recipients has not yet been established. Between November 2001 and June 2003, 343 de novo were randomized to receive steroids either tacrolimus (TAC) + sirolimus (SRL), TAC mycophenolate mofetil (MMF) or cyclosporine (CYA) MMF. Antilymphocyte induction therapy was allowed up 5 days. primary endpoint ≥3A rejection hemodynamic compromise requiring treatment showed no significant difference at 6 months (TAC/MMF...
Background— Systemic sclerosis–associated pulmonary artery hypertension (SScPAH) has a worse prognosis compared with idiopathic arterial (IPAH), median survival of 3 years after diagnosis often caused by right ventricular (RV) failure. We tested whether SScPAH or systemic sclerosis–related interstitial lung disease imposes greater vascular load than IPAH and leads to RV contractile function. Methods Results— analyzed pressures mean flow in 282 patients (166 SScPAH, 49 disease, 67 IPAH). An...
Background— A simple and effective heart failure (HF) risk score would facilitate the primary prevention early diagnosis of HF in general practice. We examined external validity existing scores, optimized a 10-year function, incremental value several biomarkers, including N-terminal pro-brain natriuretic peptide. Methods Results— During 15.5 years (210 102 person-years follow-up), 1487 events were recorded among 13 555 members biethnic Atherosclerosis Risk Communities (ARIC) Study cohort....