Al Ozonoff
A5082357489- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Data-Driven Disease Surveillance
- Venous Thromboembolism Diagnosis and Management
- LGBTQ Health, Identity, and Policy
- Immune responses and vaccinations
- Cancer survivorship and care
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Neonatal Respiratory Health Research
- MRI in cancer diagnosis
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Patient Safety and Medication Errors
- Occupational Health and Safety Research
- Global Cancer Incidence and Screening
- Dementia and Cognitive Impairment Research
- Family Support in Illness
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Vaccine Coverage and Hesitancy
- Liver Disease Diagnosis and Treatment
- Healthcare Policy and Management
- COVID-19 epidemiological studies
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
Broad Institute
2022-2025
Boston Children's Museum
2013-2025
Massachusetts Institute of Technology
2022-2024
The Coordinating Center
2022-2024
Università Cattolica del Sacro Cuore
2023
Servicio Canario de la Salud
2023
Agostino Gemelli University Polyclinic
2023
Weatherford College
2021
To evaluate the impact of state supported overdose education and nasal naloxone distribution (OEND) programs on rates opioid related death from acute care utilization in Massachusetts.Interrupted time series analysis 2002 to 2009 comparing community-year strata with high low OEND implementation those no implementation.19 Massachusetts communities (geographically distinct cities towns) at least five fatal overdoses each years 2004 2006.OEND was implemented among users risk for overdose,...
BACKGROUND: Lesbian, gay, and bisexual populations are not part of cancer surveillance, resulting in scarce information about the survivorship these populations. To address this gap, authors examined prevalence by sexual orientation survivors' self-reported health orientation. METHODS: The explored issues analyzing pooled data from California Health Interview survey 2001, 2003, 2005. By using descriptive statistics logistic regressions, they men women subsequently compared male female...
Systems biology can unravel complex but has not been extensively applied to human newborns, a group highly vulnerable wide range of diseases. We optimized methods extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml blood, volume readily obtained newborns. Indexing baseline applying innovative integrative computational reveals dramatic changes along remarkably stable developmental trajectory over the first week life. This is...
Global deployment of vaccines that can provide protection across several age groups is still urgently needed to end the COVID-19 pandemic, especially in low- and middle-income countries. Although against SARS-CoV-2 based on mRNA adenoviral vector technologies have been rapidly developed, additional practical scalable are required meet global demand. Protein subunit formulated with appropriate adjuvants represent an approach address this urgent need. The receptor binding domain (RBD) a key...
Abstract Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated female sex distinctive comorbidities. During...
Abstract Background Respiratory syncytial virus (RSV) circulation dropped markedly early in the COVID-19 pandemic, followed by a resurgence with heightened case counts. The “immunity debt” hypothesis proposes that RSV-naїve pediatric population increased during period of low transmission. However, evidence supporting this is limited, and role changing testing practices perceived surge has not been comprehensively evaluated. Methods We conducted multicenter, retrospective analysis 342 530 RSV...
Journal Article Evaluating elements of executive functioning as predictors instrumental activities daily living (IADLs) Get access Angela L. Jefferson, Jefferson * aDepartment Psychiatry & Human Behavior, Brown Medical SchoolProvidence, RI, USAbDepartment Neurology, Alzheimer's Disease Center, Boston University School Medicine, Robinson ComplexSuite 7800, 715 Albany Street, Boston, MA 02118-2526, USA *Corresponding author. Fax: +1 617 414 1197. E-mail address angelaj@bu.edu Search for other...
To determine the performance of positron emission mammography (PEM), as compared with magnetic resonance (MR) imaging, including effect on surgical management, in ipsilateral breasts cancer.Four hundred seventy-two women newly diagnosed breast cancer who were offered breast-conserving surgery consented from September 2006 to November 2008 participate a multicenter institutional review board-approved, HIPAA-compliant protocol. Participants underwent contrast material-enhanced MR imaging and...
One approach to preventing opioid overdose, a leading cause of premature, preventable mortality, is provide overdose education and naloxone distribution (OEND). Two outstanding issues for OEND implementation include 1) the dissemination training from trained untrained community members; 2) concern that provides active substance users with false sense security resulting in increased use.To compare rescue behaviors between rescuers among people reporting kit use; determine whether heroin use...
Background— Oral anticoagulation is safer and more effective when patients receive high-quality care. However, there have been no prior efforts to measure quality of oral care or risk adjust it ensure credible comparisons. Our objective was profile site performance in the Veterans Health Administration (VA) using risk-adjusted percent time therapeutic range (TTR). Methods Results— We included 124 551 who received outpatient from 100 VA sites for indications other than valvular heart disease...
Neonatal administration of BCG vaccine rapidly increases neutrophil production to reduce mortality from sepsis.
Infection is the most common cause of mortality in early life, and immunization promising biomedical intervention to reduce this burden. However, newborns fail respond optimally vaccines. Adjuvantation a key approach enhancing vaccine immunogenicity, but responses human newborn leukocytes candidate adjuvants, including TLR agonists, are functionally distinct. Herein, we demonstrate that 3M-052 locally acting lipidated imidazoquinoline TLR7/8 agonist adjuvant mice, which, when properly...
BACKGROUND: The national incidence of neonatal abstinence syndrome (NAS) has increased with the opioid epidemic in United States. impact pharmacologic treatment on hospital use is not well established. We examined recent population neonates NAS admitted to pediatric hospitals, variation treatment, and effect resource during hospitalization, including length stay (LOS), readmission, cost-of-living adjusted costs. METHODS: included inpatients discharged between January 2013 March 2016 from...
Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions across globe generating formulations that may differ in clinical efficacy. Innate immune recognition of BCG contributes to immunogenicity suggesting differences viability contribute divergent activity licensed formulations.We compared BCG-Denmark (DEN), -Japan (JPN), -India (IND), -Bulgaria (BUL) and -USA vitro with respect a) as measured by colony-forming units (CFU),...
Better understanding of the association between characteristics patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management.
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1–3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling >15,000 longitudinal blood nasal samples 540 participants the using 14 distinct assays. These unbiased analyses identify cellular molecular signatures present within 72 h hospital admission that...
BACKGROUNDPatients hospitalized for COVID-19 exhibit diverse clinical outcomes, with outcomes some individuals diverging over time even though their initial disease severity appears similar to that of other patients. A systematic evaluation molecular and cellular profiles the full course can link immune programs coordination progression heterogeneity.METHODSWe performed deep immunophenotyping conducted longitudinal multiomics modeling, integrating 10 assays 1,152 Immunophenotyping Assessment...
Abstract Objective To characterize symptoms and signs of AL amyloidosis that may bring patients to the attention rheumatologists, evaluate Ig V L gene usage in this subgroup patients, assess impact soft tissue bone involvement on survival. Methods Clinical features were assessed 191 with amyloidosis. sequencing was carried out determine light‐chain family, rate somatic mutation, evidence antigen selection. The association by logistic regression analysis, survival time analyzed using log rank...