A5100371437- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Neurological disorders and treatments
- Muscle activation and electromyography studies
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Shoulder Injury and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Orthopedic Surgery and Rehabilitation
- Transcranial Magnetic Stimulation Studies
- Medical Imaging Techniques and Applications
- Tendon Structure and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Anatomy and Medical Technology
- Visual perception and processing mechanisms
- Neural and Behavioral Psychology Studies
- Multisensory perception and integration
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Foot and Ankle Surgery
- Urinary Bladder and Prostate Research
- Long-Term Effects of COVID-19
- Traumatic Brain Injury Research
University of Southern California
2013-2024
Neurological Surgery
2016-2024
Icahn School of Medicine at Mount Sinai
2022-2024
California Institute of Technology
2007-2024
Loyola University Chicago
2024
Rancho Los Amigos National Rehabilitation Center
2019-2024
Loyola University Medical Center
2024
Einstein Healthcare Network
2023
Thomas Jefferson University
2023
Thomas Jefferson University Hospital
2023
Brain imagination to control external devices Studies in monkeys have implicated the brain's posterior parietal cortex high-level coding of planned and imagined actions. Aflalo et al. implanted two microelectrode arrays a tetraplegic patient (see Perspective by Pruszynski Diedrichsen). They asked imagine various types limb or eye movements. As predicted, motor imagery involved same neural population activity actual movements, which could potentially be exploited prosthetic control. Science ,...
First released in 2006, DrugBank (https://go.drugbank.com) has grown to become the 'gold standard' knowledge resource for drug, drug-target and related pharmaceutical information. is widely used across many diverse biomedical research clinical applications, averages more than 30 million views/year. Since its last update 2018, we have been actively enhancing quantity quality of drug data this knowledgebase. In latest release (DrugBank 6.0), number FDA approved drugs from 2646 4563 (a 72%...
Pioneering work with nonhuman primates and recent human studies established intracortical microstimulation (ICMS) in primary somatosensory cortex (S1) as a method of inducing discriminable artificial sensation. However, these sensations do not yet provide the breadth cutaneous proprioceptive percepts available through natural stimulation. In tetraplegic two microelectrode arrays implanted S1, we report replicable elicitations both modalities localized to contralateral arm, dependent on...
Abstract Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated female sex distinctive comorbidities. During...
Abstract Speech brain–machine interfaces (BMIs) translate brain signals into words or audio outputs, enabling communication for people having lost their speech abilities due to diseases injury. While important advances in vocalized, attempted and mimed decoding have been achieved, results internal are sparse yet achieve high functionality. Notably, it is still unclear from which areas can be decoded. Here two participants with tetraplegia implanted microelectrode arrays located the...
Humans shape their hands to grasp, manipulate objects, and communicate. From nonhuman primate studies, we know that visual motor properties for grasps can be derived from cells in the posterior parietal cortex (PPC). Are non-grasp-related hand shapes humans represented similarly? Here show first time how single neurons PPC of are selective particular imagined independent graspable objects. We find imagery successfully decoded by implementing a version popular Rock-Paper-Scissors game its...
The cortical grasp network encodes planning and execution of grasps processes spoken written aspects language. High-level areas within this are attractive implant sites for brain-machine interfaces (BMIs). While a tetraplegic patient performed motor imagery vocalized speech, neural activity was recorded from the supramarginal gyrus (SMG), ventral premotor cortex (PMv), somatosensory (S1). In SMG PMv, five imagined were well represented by firing rates neuronal populations during visual cue...
Abstract Objective . In electrophysiology, microelectrodes are the primary source for recording neural data (single unit activity). These can be implanted individually or in form of arrays containing dozens to hundreds channels. Recordings some channels contain activity, which often contaminated with noise. Another fraction does not record any data, but only By noise, we mean physiological activities unrelated spiking, including technical artifacts and neurons that too far away from...
Mesenchymal stromal cells (MSC) hold great promise for tissue engineering applications and cell‐based therapies. Large cell doses (>1 × 10 6 kg −1 ) Good Manufacturing Practices (GMP)‐compliant processes are however required clinical purposes. Here, a serum‐ xenogeneic‐free (S/XF) microcarrier‐based culture system is established the expansion of human umbilical cord matrix (UCM)‐ adipose (AT)‐derived MSC using Vertical‐Wheel (PBS‐0.1 MAG; PBS Biotech). UCM AT expanded to maximum densities...
Abstract Objective. Intracortical microelectrode arrays (MEA) can be used as part of a brain–machine interface system to provide sensory feedback control an artificial limb assist persons with tetraplegia. Variability in functionality electrodes has been reported but few studies humans have examined the impact chronic brain tissue responses revealed postmortem on electrode performance vivo. Approach. In tetraplegic man, recording MEAs were implanted into anterior intraparietal area and...
Existing brain-computer interface (BCI) control of highly dexterous robotic manipulators and prosthetic devices typically rely solely on neural decode algorithms to determine the user's intended motion. Although these approaches have made significant progress in ability high degree freedom (DOF) manipulators, perform activities daily living (ADL) is still an ongoing research endeavor. In this paper, we describe a hybrid system that combines elements autonomous manipulation with maneuver...
BACKGROUND: The concept of Perioperative Surgical Home has been gaining significant attention in surgical centers. This model is delivering and improving coordinated care a cost-effective manner to patients undergoing procedures. It starts with the decision for intervention, continues intraoperative postoperative periods, follows into long-term recovery. Constant re-evaluation outcomes modifications delivery provides feedback loop improvement. Children’s Hospital Los Angeles initiated new...
Recent literature suggests that tactile events are represented in the primary somatosensory cortex (S1) beyond its long-established topography; addition, extent to which S1 is modulated by vision remains unclear. To better characterize S1, human electrophysiological data were recorded during touches forearm or finger. Conditions included visually observed physical touches, without vision, and visual contact. Two major findings emerge from this dataset. First, strongly modulates area 1, but...
INTRODUCTION: A body of evidence has defined the role amygdala in processing emotional and fearful stimuli; however, recent suggests a motor as well. We have shown previously that baseline beta-band (13–30Hz) power hippocampus is different between Direct Reach(DR) Go/No-Go(GNG) tasks, which indicates influenced by movement uncertainty. METHODS: Local field potentials (LFPs) were recorded from stereoelectroencephalogram (SEEG) contacts 14 participants during DR GNG tasks. Baseline spectral...