Keisha Gibson
A5000174134- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Autoimmune Bullous Skin Diseases
- Dialysis and Renal Disease Management
- Adolescent and Pediatric Healthcare
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pregnancy and Medication Impact
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Sclerosis and Related Diseases
- Trauma and Emergency Care Studies
- Renal and related cancers
- Acute Kidney Injury Research
- Ion Transport and Channel Regulation
- Healthcare Policy and Management
- Cell Adhesion Molecules Research
- Abdominal vascular conditions and treatments
- Abdominal Trauma and Injuries
- Urticaria and Related Conditions
- Platelet Disorders and Treatments
- Tuberous Sclerosis Complex Research
- Chronic Lymphocytic Leukemia Research
- Bipolar Disorder and Treatment
- Hepatitis C virus research
University of North Carolina at Chapel Hill
2016-2025
Children's Hospital of Philadelphia
2017-2024
Kidney Associates
2021-2024
University of North Carolina Health Care
2018-2023
University of North Carolina Wilmington
2023
Washington University in St. Louis
2023
University of Minnesota
2023
Association of American Medical Colleges
2023
Tulane University
2023
American Society of Nephrology
2023
The Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Clinical Practice Guideline for the Management of Glomerular Diseases is an update to KDIGO 2012 guideline on topic. aim assist clinicians caring individuals with glomerular disease, both adults and children. scope includes various diseases, including IgA nephropathy (IgAN) vasculitis (IgAV), membranous nephropathy, nephrotic syndrome in children, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS),...
The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Glomerular Diseases is an update to KDIGO 2012 guideline. aim assist clinicians caring individuals with glomerulonephritis (GN), both adults and children. scope includes various glomerular diseases, including IgA nephropathy vasculitis, membranous nephropathy, nephrotic syndrome, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), infection-related GN, antineutrophil...
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that exhibits familial aggregation and may progress to end-stage renal disease (ESRD). LN more prevalent among African Americans than European Americans. This study was undertaken investigate the hypothesis apolipoprotein L1 gene (APOL1) nephropathy risk alleles G1/G2, common in rare Americans, contribute ethnic disparity risk.APOL1 G1 G2 were genotyped 855 American SLE patients with LN-ESRD (cases) 534...
The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a Controversies Conference on glomerular diseases in November 2017. conference focused the 2012 KDIGO guideline with aim of identifying new insights into nomenclature, pathogenesis, diagnostic work-up, and, particular, therapy since guideline's publication. It was consensus group that most recommendations, particular those dealing therapy, will need to be revisited by guideline-updating Work Group. This report covers...
In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative brought a diverse panel of experts in glomerular diseases together to discuss 2012 KDIGO glomerulonephritis guideline context new developments and insights that had occurred over years since its publication. During this Controversies Conference on Glomerular Diseases, group examined data disease pathogenesis, biomarkers, treatments identify areas consensus controversy. This report summarizes discussions...
The application of deep learning for automated segmentation (delineation boundaries) histologic primitives (structures) from whole slide images can facilitate the establishment novel protocols kidney biopsy assessment. Here, we developed and validated networks structures on biopsies nephrectomies. For development, examined 125 Minimal Change Disease collected across 29 NEPTUNE enrolling centers along with 459 stained Hematoxylin & Eosin (125), Periodic Acid Schiff Silver (102), Trichrome...
AURORA 2 evaluated the long-term safety, tolerability, and efficacy of voclosporin compared to placebo in patients with lupus nephritis (LN) receiving an additional two years treatment following completion one-year 1 study.
The diagnosis of nephrotic syndrome relies on clinical presentation and descriptive patterns injury kidney biopsies, but not specific to underlying pathobiology. Consequently, there are variable rates progression response therapy within diagnoses. Here, an unbiased transcriptomic-driven approach was used identify molecular pathways which shared by subgroups patients with either minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS). Kidney tissue transcriptomic...
Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) poised to address these challenges. study has enrolled >850 pediatric adult patients with proteinuric glomerular who have contributed deep clinical, histologic, genetic, profiles...
Background: The Centers for Disease Control and Prevention (CDC) Environmental Justice Index Social-Environmental Ranking (EJI-SER) combines a Social Vulnerability Module (SV) with an Burden (EB) to characterize cumulative environmental social burden at the census tract level. This analysis evaluates association between EJI-SER kidney outcomes in glomerular disease (GD) patients. Methods: Cure Glomerulopathy (CureGN) is observational cohort study of adults children biopsy-proven GD....
Individuals of African ancestry harboring two variant alleles within apolipoprotein L1 ( APOL1 ) are classified with a high-risk (HR) genotype. Adults an HR genotype have increased risk focal segmental glomerulosclerosis and chronic kidney disease compared those low-risk (LR) (0 or 1 variants). The role genotypes in children glomerular is less well known.This study characterized 104 African-American by cohorts: the Chronic Kidney Disease Children (CKiD) Nephrotic Syndrome Study Network...
Alport syndrome is an inherited disease characterized by progressive loss of kidney function. We aimed to evaluate the safety and efficacy bardoxolone methyl in patients with syndrome.We randomly assigned syndrome, ages 12-70 years eGFR 30-90 ml/min per 1.73 m2, (n=77) or placebo (n=80). Primary end points were change from baseline at weeks 48 100. Key secondary 52 104, after intended 4 off treatment. Safety was assessed monitoring for adverse events vital signs, 12-lead electrocardiograms,...
The American Society of Nephrology (ASN) Task Force on the Future was established in April 2022 response to requests from Board Internal Medicine and Accreditation Council for Graduate Medical Education regarding training requirements nephrology. Given recent changes kidney care, ASN also charged task force with reconsidering all aspects specialty's future ensure that nephrologists are prepared provide high-quality care people diseases. engaged multiple stakeholders develop 10...
The prevalence and significance of remission relapse in children, adolescents, young adults with lupus nephritis the United States are poorly understood. Patterns predictors disease progression a southeastern U.S. pediatric cohort severe presented.Individuals age 21 or less kidney biopsy-proven followed Glomerular Disease Collaborative Network were included. Cox regression models used to evaluate end stage (ESKD).Seventy-three subjects mean 15.6 +/- 3.4 yr Five-year survival was 77%....
This analysis from the Nephrotic Syndrome Study Network (NEPTUNE) assessed phenotypic and pathology characteristics of proteinuric patients undergoing kidney biopsy defined frequency factors associated with complete proteinuria remission (CRever).We enrolled adults children ≥0.5 g/d at time first clinically indicated renal 21 sites in North America April 2010 to June 2014 into a prospective cohort study. NEPTUNE central pathologists assigned participants minimal-change disease (MCD), FSGS,...
IntroductionNephrotic syndrome (NS) is a characterized by massive proteinuria, edema, hypoalbuminemia, and dyslipidemia. Glucocorticoids (GCs), the primary therapy for >60 years, are ineffective in approximately 50% of adults 20% children. Unfortunately, there no validated biomarkers able to predict steroid-resistant NS (SRNS) or define pathways regulating SRNS.MethodsWe performed proteomic analyses on paired pediatric patient plasma samples obtained both at disease presentation before...
<b><i>Introduction:</i></b> Alport syndrome is a rare genetic disorder that affects as many 60,000 persons in the USA and total of 103,000 (&#x3c;5 per 10,000) European Union [1, 2]. It second most common inherited cause kidney failure characterized by progressive loss function often leads to end-stage disease. Currently, there are no approved disease-specific agents for therapeutic use. We designed phase 3 study (CARDINAL; NCT03019185) evaluate safety,...