A5077764269- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Complement system in diseases
- Chronic Kidney Disease and Diabetes
- Autoimmune Bullous Skin Diseases
- Liver Diseases and Immunity
- Hepatitis C virus research
- Systemic Sclerosis and Related Diseases
- Central Venous Catheters and Hemodialysis
- Transplantation: Methods and Outcomes
- Sarcoidosis and Beryllium Toxicity Research
- Urticaria and Related Conditions
- Liver Disease Diagnosis and Treatment
- Pregnancy and Medication Impact
- Acute Kidney Injury Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- T-cell and B-cell Immunology
- IgG4-Related and Inflammatory Diseases
Post Graduate Institute of Medical Education and Research
2015-2024
Institute of Medical Sciences
2018-2024
Texas A&M University
2024
Creative Commons
2023
Institute of Post Graduate Medical Education and Research
2021
Alexion Pharmaceuticals (United States)
2014
Pediatric Nephrology of Alabama
2010
All India Institute of Medical Sciences
2008
The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a Controversies Conference on glomerular diseases in November 2017. conference focused the 2012 KDIGO guideline with aim of identifying new insights into nomenclature, pathogenesis, diagnostic work-up, and, particular, therapy since guideline's publication. It was consensus group that most recommendations, particular those dealing therapy, will need to be revisited by guideline-updating Work Group. This report covers...
In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative brought a diverse panel of experts in glomerular diseases together to discuss 2012 KDIGO glomerulonephritis guideline context new developments and insights that had occurred over years since its publication. During this Controversies Conference on Glomerular Diseases, group examined data disease pathogenesis, biomarkers, treatments identify areas consensus controversy. This report summarizes discussions...
There have been very few studies comparing cyclophosphamide (CTX) and calcineurin inhibitor based regimens in the management of non-immunosuppressive symptomatic therapy (NIST) resistant idiopathic membranous nephropathy (IMN). The present study was aimed at efficacy safety tacrolimus (TAC)/steroids with cyclical CTX/steroids (Modified Ponticelli regimen (MPR)) patients IMN.Idiopathic (n = 70) persistent nephrotic syndrome after least 6 months antiproteinuric or complications were equally...
IntroductionThe coronavirus disease 2019 (COVID-19) pandemic has affected the care of patients with noncommunicable diseases, including those suffering from kidney-related ailments. Many parts world, India, adopted lockdown to curb community transmission disease. The transportation, access health facilities, and availability medicines consumables as well outpatient inpatient services. We aimed analyze effect imposed due COVID-19 on kidney diseases in India.MethodsWe surveyed 19 major...
Acute kidney injury (AKI), particularly community-acquired AKI (CA-AKI), is a major health concern globally. The International Society of Nephrology's “0 by 25” initiative to reduce preventable deaths from zero 2025 not achievable in low and middle income countries, such as India, possibly due lack data measures tackle this urgent public issue. In CA-AKI predisposes younger patients hospitalization, morbidity, mortality. This the first multicenter, prospective, cohort study investigating its...
Sexual and gonadal dysfunction/infertility are quite common in patients with chronic kidney disease. Forty percent of male 55% female dialysis do not achieve orgasm. The pathophysiology dysfunction is multifactorial. It usually a combination psychological, physiological, other comorbid factors. Erectile males mainly due to arterial factors, venous leakage, psychological neurogenic endocrine drugs. females hormonal factors manifests as menstrual irregularities, amenorrhea, lack vaginal...
Antibodies to M-type phospholipase A2 receptor (PLA2R) correlate with clinical activity of primary membranous nephropathy (PMN). Risk alleles in PLA2R1 and HLA-DQA1 genes are associated PMN. Whether these the development anti-PLA2R is unknown. In this prospective study we evaluated anti-PLA2R, enhanced glomerular staining for PLA2R variations Indian patients PMN examined their association response treatment.A total 114 adult were studied. Anti-PLA2R was estimated before treatment after 6 12...
Objective Deficiency of adenosine deaminase 2 (DADA2) is a potentially fatal monogenic syndrome characterized by variable manifestations systemic vasculitis, bone marrow failure, and immunodeficiency. Most cases are diagnosed pediatric care providers, given the typical early age disease onset. This study was undertaken to describe clinical phenotypes treatment response both in adults children with DADA2 India. Methods A retrospective analysis adult patients at various rheumatology centers...
The current treatment regimes for patients with nephrotic syndrome due to idiopathic membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS) are based on steroids and/or cytotoxic agents. Data the effect of mycophenolate mofetil (MMF) these conditions scarce confounding.We compared efficacy an MMF-based therapy standard therapies in inducing remission adult nephrotics MN FSGS a randomized pilot study. MMF was given at 2 g/day 6 months along prednisolone 0.5 mg/kg/day 2-3...
End points currently used in lupus nephritis (LN) clinical trials lack uniformity and questionably reflect long-term kidney survival. This study was undertaken to identify short-term end that predict outcomes for use trials.
IntroductionBoth cCTX/GCs and CNIs are recommended as first-line agents in the management of PMN. The present study is an extended report patients randomized to receive TAC/GCs or at 2 years post randomization.MethodsSeventy enrolled clinical trial Tacrolimus Combined With Corticosteroids Versus Modified Ponticelli Regimen Treatment Idiopathic Membranous Nephropathy: Randomized Control Trial were followed quarterly between 12 24 months. At end months, 3 lost follow-up.ResultsAt 18 66% 89% (P...
Introduction The ongoing pandemic of COVID-19 has led to severe disruption healthcare services worldwide. We conducted this study assess the impact on management Systemic Lupus Erythematosus (SLE) patients who were enrolled in nation-wide inception cohort. Methods A questionnaire was administered SLE Questions related effect disease activity, preventive measures adopted against COVID-19, incidence hardships faced getting access health care professionals and availability medicines, adherence,...
Abstract Aim To describe the clinical features, treatment and long‐term outcomes in north Indian patients with granulomatosis polyangiitis ( GPA ). Methods Clinical details, Birmingham Vasculitis Activity Score BVAS ‐v3), laboratory data, histopathology findings, details of all consecutive diagnosed as having between April 2005 2016 were retrieved. European Study Group definitions used to classify into localized, early systemic, generalized, severe refractory categories. The findings...
IntroductionManagement of adults with steroid-resistant (SR) nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS) is a challenging task. Is tacrolimus (TAC) effective in this situation without serious adverse effects? This prospective study was done answer question.
<i>Background:</i> Until now, a normal reference range for glomerular filtration rate (GFR) in adult Indian potential kidney donors has not been determined and values from western population are being used as reference. <i>Aim:</i> To determine the of GFR healthy donors. <i>Basic Procedures:</i> was measured 610 (250 male, 360 female, average age 35.16 years) using <sup>99m</sup>Tc-DTPA (diethylenetriamine pentaacetic acid) two-plasma sample...