A5057591920- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Inflammatory Myopathies and Dermatomyositis
- Cytokine Signaling Pathways and Interactions
- Liver Diseases and Immunity
- Vasculitis and related conditions
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Diabetes and associated disorders
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Complement system in diseases
- Reproductive System and Pregnancy
- Sarcoidosis and Beryllium Toxicity Research
- Salivary Gland Disorders and Functions
Jawaharlal Institute of Post Graduate Medical Education and Research
2016-2025
All India Institute of Medical Sciences
2022-2025
All India Institute of Medical Sciences Raipur
2023-2025
All India Institute of Medical Sciences Bhopal
2023-2025
AstraZeneca (France)
2023
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2017
Sri Manakula Vinayagar Medical College and Hospital
2016
Hôpital Saint-Louis
2016
Inserm
2016
Uniformed Services University of the Health Sciences
2015
This study aimed to test whether immunosuppressant (IS) withdrawal is noninferior glucocorticoid (GC) in patients with Systemic Lupus Erythematosus (SLE) remission. In this open-label, single-center, randomized (1:1) controlled trial, we compared flare occurrence stable SLE undergoing GC or IS tapering. Patients aged >18, on (prednisolone ≤7.5 mg/day) and maintenance non-biological for ≥3 years, clinical remission ≥1 year, were enrolled assigned taper over 3 months. The primary end point was...
Objective Deficiency of adenosine deaminase 2 (DADA2) is a potentially fatal monogenic syndrome characterized by variable manifestations systemic vasculitis, bone marrow failure, and immunodeficiency. Most cases are diagnosed pediatric care providers, given the typical early age disease onset. This study was undertaken to describe clinical phenotypes treatment response both in adults children with DADA2 India. Methods A retrospective analysis adult patients at various rheumatology centers...
Limited information is available on the prevalence of gallstones in first-degree relatives gallstone patients. Three groups subjects were studied by real-time ultrasound examination: group A, 105 index patients (male/female; 20:85); B, 330 patients; C, matched controls for A (n = 105) and B 330) subjects. Dietary, anthropometric, biochemical investigations carried out. In 39 (37%) cases, one or more additional family members had (positive-index case). The positive-index cases younger than...
Abstract Objectives To assess acceptability of teleconsultation among the socioeconomically marginalized sections patients with rheumatic and musculoskeletal diseases (RMDs), to identify socioeconomic barriers in continuing rheumatology care during COVID-19 crisis who could benefit by shifting tele-rheumatology consultations. Methods This was a cross sectional analytical study done at tertiary teaching hospital India including RMDs were not on biological modifying agents. Assessment disease...
Background: Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease. Antirheumatoid treatment reduces disease activity and inflammation, but not all patients respond to treatment. Autonomic dysfunction common in RA leading frequent cardiovascular complications. Yoga therapy may be useful these patients, there are little data on the effect of yoga activity, markers, heart rate variability (HRV). Objectives: This study assessed 12-week HRV with RA. Materials Methods: randomized...
The study was aimed at identification by proteomics and validation enzyme-linked immunosorbent assay (ELISA) of potential urinary biomarkers for lupus nephritis. Study subjects comprised 88 systemic erythematosus (SLE) patients 60 controls (rheumatoid arthritis, diabetes mellitus healthy individuals). Based on the SLE disease activity index (SLEDAI), were classified as active renal (AR), non-renal (ANR) or inactive (ID). Urinary proteins from a group with AR ID resolved two-dimensional gel...
JAK1 plays a significant role in the intracellular signaling by interacting with cytokine receptors different types of cells and is linked to pathogenesis various cancers pathology immune system. In this study, ligand-based pharmacophore modeling combined virtual screening molecular docking methods was incorporated identify potent selective lead compounds for JAK1. Initially, models were generated using set 52 inhibitors named C-2 methyl/hydroxyethyl imidazopyrrolopyridines derivatives....
ABSTRACT Mechanisms contributing to non‐response treatment in lupus nephritis (LN) are unclear. We characterised the transcriptome of paired peripheral blood mononuclear cells (PBMCs) and renal tissues LN before after cyclophosphamide (CYC) identified markers that predicted response. Total RNA isolated from PBMCs ( n = 32) 25) 16 proliferative CYC treatment, 6 months post‐treatment, during flare, was sequenced on Illumina Novaseq‐6000 platform. Post‐treatment, eight patients were clinical...
Primary immune deficiency disorders (PIDs) are a heterogeneous group of with symptoms overlapping common diseases leading to delay in diagnosis. Many have autosomal recessive inheritance and present early childhood. We report the phenotypic molecular profile PIDs from tertiary care center south India that caters population high (∼35%) rate consanguinity. The clinical data total 101 unrelated patients diagnosed were collected analyzed. Among our patients, hyper IgE syndrome (15.8%) followed...
NKG2D (KLRK1) is a C-type lectin receptor present on natural killer (NK) cells, γδ, CD8+ and CD4+ T cells. Upon ligand binding, mediates activatory co-stimulatory signals to NK cells activated respectively. Polymorphisms in predispose infectious diseases, cancer, transplantation autoimmune disorders. We studied the influence of this polymorphism predisposition modification disease phenotype patients with rheumatoid arthritis (RA). Eight different single nucleotide polymorphisms (SNP) NKG2...