A5024478732- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Parasitic Infections and Diagnostics
- T-cell and B-cell Immunology
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
- Genetic Syndromes and Imprinting
- Rheumatoid Arthritis Research and Therapies
- Diabetes and associated disorders
- Genetic Neurodegenerative Diseases
- Atherosclerosis and Cardiovascular Diseases
- Biochemical and Molecular Research
- Assisted Reproductive Technology and Twin Pregnancy
- Vascular Malformations and Hemangiomas
- Complement system in diseases
- Amoebic Infections and Treatments
- Hormonal Regulation and Hypertension
- Coccidia and coccidiosis research
- Prenatal Screening and Diagnostics
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Metabolism and Genetic Disorders
- Liver Diseases and Immunity
- Protein Tyrosine Phosphatases
- Scoliosis diagnosis and treatment
Jawaharlal Institute of Post Graduate Medical Education and Research
2016-2025
Gates Foundation
2023
Christie's
2021
Creative Commons
2021
University of Padua
2020
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2017
All India Institute of Medical Sciences
2002
Cervical cancer burden is high where prophylactic vaccination and screening coverage are low. We demonstrated in a multicenter randomized, double-blind, controlled trial that single-dose human papillomavirus (HPV) had vaccine efficacy (VE) against persistent infection at 18 months Kenyan women. Here, we report findings of this through 3 years follow-up. Overall, 2,275 healthy women aged 15-20 were recruited randomly assigned to receive bivalent (n = 760), nonavalent 758) or control 757)...
Primary immune deficiency disorders (PIDs) are a heterogeneous group of with symptoms overlapping common diseases leading to delay in diagnosis. Many have autosomal recessive inheritance and present early childhood. We report the phenotypic molecular profile PIDs from tertiary care center south India that caters population high (∼35%) rate consanguinity. The clinical data total 101 unrelated patients diagnosed were collected analyzed. Among our patients, hyper IgE syndrome (15.8%) followed...
Background. Duchenne muscular dystrophy (DMD) is a progressive X-linked dystrophinopathy with onset in early childhood. Affected individuals present predominantly proximal lower limb weakness and pseudohypertrophy of calf musculature being prominent sign, heralding the contractures large joints limbs. Kocher-Debre-Semelaigne syndrome (KDSS) refers to that develops children long-standing hypothyroidism. Case Presentation. We an 11-year-old boy walking difficulty for two years associated...
To find the association of ATIC 347C>G gene polymorphism with methotrexate (MTX) treatment response and MTX-induced adverse events in south Indian Tamil patients rheumatoid arthritis.A total 319 arthritis 310 healthy controls were recruited for study was analyzed by PCR-RFLP method.The genotype allele frequencies 347 C>G SNP did not differ between good nonresponders hence this found to be associated MTX response. However, GG (p = 0.02; odds ratio [OR]: 4.46; 95% CI: 1.28-15.52) mutant G...
Abstract Systemic lupus erythematosus ( SLE ) is a prototype autoimmune disease with complex etiology. Loss of immune tolerance and synthesis autoantibodies against nuclear antigens contributes to the disease. Genetic aberrations disrupting functions regulatory receptors may facilitate development diseases. Cytotoxic T‐lymphocyte antigen 4 CTLA4 an inhibitory receptor for T cells this study was carried out analyze influence + 49A /G (rs231775) polymorphism on susceptibility in ethnic Tamils....
Abstract Aim The aim of the study was to assess distribution human leukocyte antigen (HLA)‐B*27 subtypes and its correlation with disease phenotypes in children enthesitis‐related arthritis variant juvenile idiopathic (JIA‐ERA). Method One hundred sixty patients (132 males, 28 females) satisfying International League Against Rheumatism (ILAR) classification criteria for JIA‐ERA were assessed relevant demographic, clinical radiographic data documented. HLA‐B*27 typing done all B*27 positive...
A 4-year-old boy presented with severe bone pains, refusal to walk, diffuse bony swelling of forelimbs, skin changes and abdominal pain, symptoms evolving over 6 weeks. Blood screening tests were normal except for raised aspartate aminotransferase (AST). Radiographs revealed thickened periosteum, widening the diaphyses long bones lifted periosteum in mid-shaft ulnae right femur. Skeletal scintigraphy showed a high uptake radionuclide at clinically affected unaffected sites, suggestive...
Glutaric acidemia type 1 (GA-1, OMIM 231670) is an autosomal recessive inborn error of metabolism caused by the deficiency glutaryl-coenzyme A (CoA) dehydrogenase with most children presenting in infancy encephalopathy, dystonia, and macrocephaly. In this article, we presented clinical characteristics, molecular profile, outcomes 29 unrelated families affected (30 cases total). The mean age at onset illness was 10 months (±14.58), whereas referral for diagnosis 29.44 (±28.11). Patients were...
Genetic aberrations disrupting toll-like receptor and interferon homeostasis enhance the risk of systemic lupus erythematosus (SLE). Raised serum interferon-alpha (IFN-α) levels in SLE patients have been ascribed to polymorphism (rs2004640 G/T) regulatory factor 5 (IRF5) gene, resulting enhanced transcript splicing. A positive association between IRF5 has reported many populations. This study was aimed find out frequency rs2004640 G/T with healthy controls assess its influence on...
Acute cerebellitis (AC) is a rare inflammatory syndrome presenting as cerebellar dysfunction, seen more frequently in children. AC can have variable course with features of raised intracranial pressure and neurological deficits, sometimes even be potentially fatal due to complications such obstructive hydrocephalus brainstem compression, warranting surgical intervention. We report case 12-year-old boy who presented ataxia. Imaging CT MRI showed tonsillar herniation. He was managed...
Sir, A 30-month-old toddler with developmental delay due to congenital cytomegalovirus (CMV) infection who was on phenytoin, phenobarbitone, and carbamazepine for epilepsy, admitted fever, generalized maculopapular rash, respiratory distress of 10 days lymphadenopathy, hepatosplenomegaly, an episode seizure (initial investigations) [Table 1]. His anticonvulsants were changed levitracetam suspected drug hypersensitivity, confirmed by skin biopsy [Figure fever rashes disappeared following...
A seven month old healthy male infant was brought with papular skin lesions all over the body, which became ulcerative increasing fever and redness within 1 week duration. On examination, Bacilli Calmette Guerin (BCG) scar ulcerated discharge; irritable tachycardia tachypnea. Investigations revealed pancytopenia, acid fast bacilli positive in at BCG site. There progressive worsening of infant's condition, culminating death.
Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with complex etiology. Loss of immune tolerance against self-antigens results in activation the system to produce autoantibodies, which turn contribute clinical manifestations disease. Immune cells harbor plethora regulatory receptors. Immunoglobulin-like transcripts (ILTs) exhibit both and inhibitory properties. Genetic defects genes encoding these receptors may predispose development diseases secondary...