A5071735972- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Renal and Vascular Pathologies
- Renal and related cancers
- Cardiovascular Health and Disease Prevention
- Erythropoietin and Anemia Treatment
- Nutrition and Health in Aging
- Abdominal vascular conditions and treatments
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Renin-Angiotensin System Studies
- Liver Disease Diagnosis and Treatment
- Muscle and Compartmental Disorders
- Sodium Intake and Health
- Mesenchymal stem cell research
- Gout, Hyperuricemia, Uric Acid
- Pancreatic function and diabetes
- Esophageal and GI Pathology
- Extracellular vesicles in disease
- Healthcare and Venom Research
- Spine and Intervertebral Disc Pathology
Yonsei University
2015-2024
Severance Hospital
2013-2024
Gangnam Severance Hospital
2015-2024
University Health System
2020
Yonsei University Health System
2020
CHA Bundang Medical Center
2017
The Yeats Society of Korea
2016
Gyeongsang National University
2014
New York Medical College
2007-2012
Renal Research Institute
2007-2012
The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a Controversies Conference on glomerular diseases in November 2017. conference focused the 2012 KDIGO guideline with aim of identifying new insights into nomenclature, pathogenesis, diagnostic work-up, and, particular, therapy since guideline's publication. It was consensus group that most recommendations, particular those dealing therapy, will need to be revisited by guideline-updating Work Group. This report covers...
In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative brought a diverse panel of experts in glomerular diseases together to discuss 2012 KDIGO glomerulonephritis guideline context new developments and insights that had occurred over years since its publication. During this Controversies Conference on Glomerular Diseases, group examined data disease pathogenesis, biomarkers, treatments identify areas consensus controversy. This report summarizes discussions...
In chronic kidney disease, anemia and disordered iron homeostasis are prevalent associated with significant adverse consequences. 2012, Kidney Disease: Improving Global Outcomes (KDIGO) issued an guideline for managing the diagnosis, evaluation, treatment of in disease. Since then, new data have accrued from basic research, epidemiological studies, randomized trials that warrant a re-examination previous recommendations. Therefore, 2019, KDIGO decided to convene 2 Controversies Conferences...
We recently demonstrated the use of in vitro expanded kidney-derived mesenchymal stem cells (KMSC) protected peritubular capillary endothelial acute renal ischemia-reperfusion injury. Herein, we isolated and characterized microparticles (MPs) from KMSC. investigated their biologic effects on human vivo renoprotective MPs were supernatants KMSC cultured anoxic conditions serum-deprived media for 24 hours. KMSC-derived presence several adhesion molecules normally expressed membranes, such as...
Background In recent years, laboratory and clinical research has suggested the need for peritoneal dialysis fluids (PDFs) that are more biocompatible than conventional PDFs commonly used today. Bioincompatibility of PDF been attributed to low pH, lactate, glucose, glucose degradation products (GDPs), osmolality. with neutral pH GDPs now available commercially. vitro early studies suggest these solutions indeed but, as now, there is no evidence their use improves patient outcome. Methods...
Microparticles (MPs) derived from kidney-derived mesenchymal stem cells (KMSCs) have recently been reported to ameliorate rarefaction of peritubular capillaries (PTC) in ischemic kidneys via delivery proangiogenic effectors. This study aimed investigate whether KMSC-derived MPs show anti-fibrotic effects by ameliorating endothelial-to-mesenchymal transition (EndoMT) human umbilical vein endothelial (HUVEC) vitro and preserving PTC with unilateral ureteral obstruction (UUO) vivo. isolated the...
Background. Novel, biocompatible peritoneal dialysis (PD) solutions have become available in recent years. In 2001, low glucose degradation products (GDP), neutral pH became commercially Korea. To date, there are no reports regarding the large scale adoption of these clinical practice and what, if any, impact on patient outcomes.
Long-term peritoneal dialysis (PD) is associated with the development of various structural and functional changes to membrane when bioincompatible conventional fluids (PDFs) are used. In this study, we looked at patients that were treated PDFs then changed novel biocompatible a neutral pH low concentration glucose degradation products (GDPs) investigate whether change could result in arrest or reversal deterioration.In an open label, randomized prospective trial, clinical effects very GDPs...
In Brief Study Design. Case series retrospective review. Objective. To present the surgical treatment guideline for spinal diseases with end-stage renal disease (ESRD) patients undergoing hemodialysis. Summary of Background Data. Treatment ESRD in is a special clinical challenge because complex medical and problems. Methods. We retrospectively reviewed 12 who underwent surgeries among chronic failure at our hospital from May 2000 to September 2007. The records radiologic findings these were...
A major challenge in systems biology is integration of molecular findings for individual enzyme activities into a cohesive high-level understanding cellular metabolism and physiology/pathophysiology. However, meaningful prediction how perturbed activity will globally impact cell, tissue or intact organisms precluded by multiple unknowns, including vivo enzymatic rates, subcellular distribution pathway interactions. To address this challenge, metabolomics offers the potential to...
Abstract Background Online haemodiafiltration (OL-HDF) may improve middle molecular clearance in contrast to conventional haemodialysis (HD). However, OL-HDF requires higher convective flows and cannot sufficiently remove large molecules. This study evaluated the efficacy of a medium cut-off (MCO) dialyser removing uraemic toxins compared it with that high-flux (HF) dialysers HD predilution OL-HDF. Methods Six clinically stable patients without residual renal function were investigated....
Heavy proteinuria with or without features of nephrotic syndrome is associated many primary and systemic diseases. For diabetic patients, distinguishing nondiabetic renal disease (NDRD) from nephropathy (DN) important in choosing treatment modalities determining prognosis. However, clinical relevance heavy inconsistent DN assessments. This study investigated the clinicopathological outcomes NDRD type 2 patients nephrotic-range proteinuria. We enrolled 220 cases who underwent biopsy. They...
Recruitment of various stem and progenitor cells is crucial for the regeneration an injured organ. Levels uric acid, one prototypical "alarm signals," surge after ischemia-reperfusion injury. Exogenous acid rapidly mobilizes endothelial hematopoietic protects kidney from ischemia. The relatively fast responses to suggest that preformed second messengers may be released a storage pool. Here, it reported monosodium urate (MSU) results in exocytosis Weibel-Palade bodies vitro vivo, leading...
Renal resident stem cells were previously reported within the renal tubules and papillary area. The aim of present study was to determine whether capsules harbor this pool can be recruited parenchyma after ischemic injury. We demonstrated presence label-retaining throughout capsule, at a density ∼10 cells/mm(2), their close apposition blood vessels. By flow cytometry, in vitro cultured derived from capsule positive for mesenchymal cell (MSC) markers (CD29+, vimentin+, Sca-1+, nestin+) but...
Background: The number of elderly people on dialysis is increasing rapidly. Fluid overload and malnutrition status are serious problems in patients. We aimed to compare the hydration nutritional through bioimpedance analysis (BIA) between young hemodialysis (HD) patients analyze risk factors related fluid these Method: conducted a cross-sectional study, which 82 HD (males 42, mean age 58.7±12.9 years) were enrolled. collected different types data: laboratory data, such as serum creatinine,...
Background. Transforming growth factor‐β1 (TGF‐β1) is the major profibrotic cytokine involved in many renal diseases, and urinary TGF‐β1 reflects intrarenal production. Urinary excretion reported to be significantly increased patients with immunoglobulin A (IgA) nephropathy. The aim of present study was compare effects losartan amlodipine on proteinuria, as well serum urine levels IgA nephropathy hypertension proteinuria. Methods. initial 4 week washout period followed by 12 weeks active...
Unilateral ureteral obstruction (UUO), a model of tubulointerstitial scarring (TIS), has propensity toward regeneration renal parenchyma after release (RUUO). No information exists on the contribution stem cells to this process. We performed UUO in FVB/N mice, reversed it 10 days, and examined kidneys 3 wk RUUO. resulted attenuation parenchyma. FACS analysis endothelial progenitor (EPC), mesenchymal (MSC) hematopoietic (HSC) obtained from by collagenase-dispersed single-cell suspension...