A5086073306- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Organ Transplantation Techniques and Outcomes
- Chronic Kidney Disease and Diabetes
- Metabolism and Genetic Disorders
- Organ Donation and Transplantation
- Nutrition and Health in Aging
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Transplantation: Methods and Outcomes
- Biomedical Research and Pathophysiology
- Muscle and Compartmental Disorders
- Blood Pressure and Hypertension Studies
- Inflammation biomarkers and pathways
- Acute Kidney Injury Research
- Iron Metabolism and Disorders
- Extracellular vesicles in disease
- Apelin-related biomedical research
- Cardiovascular Function and Risk Factors
- Vitamin D Research Studies
- Mitochondrial Function and Pathology
- Drug-Induced Hepatotoxicity and Protection
- Neurological Complications and Syndromes
CHA Bundang Medical Center
2019-2025
CHA University
2019-2025
Kyung Hee University Hospital at Gangdong
2015-2021
Kyoto University
2020-2021
Kyung Hee University
2013-2020
University School
2020
Korea University
2020
Yonsei University
2020
Severance Hospital
2020
Kyung Hee University Medical Center
2018
We examined the effects of empagliflozin, a selective inhibitor Na+-glucose cotransporter 2, on mitochondrial quality control and autophagy in renal tubular cells diabetic environment vivo vitro. Human proximal (hRPTCs) were incubated under high-glucose conditions. Diabetes was induced with streptozotocin male C57BL/6J mice. Improvements biogenesis balanced fusion-fission protein expression noted hRPTCs after treatment empagliflozin media. Empagliflozin also increased autophagic activities...
The NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome has been implicated in renal inflammation and fibrosis. However, the biological function of inflammasome-independent NLRP3 non-immune cells is still unclear. We evaluated role tubular assessed value as a therapeutic target for acute kidney injury (AKI). Various cell lines primary cultured from knockout (KO) mice were used vitro studies. also tested AKI with unilateral ureter obstruction model (UUO). Hypoxia induced...
Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, two most commonly used methods assessing performance. obtained data regarding strength from 277 evaluated their relationships baseline parameters, mental health, plasma inflammatory markers, major adverse outcomes. was defined by recommendations suggested Asian Working Group on Sarcopenia. The prevalence...
Abstract Background PTEN-induced kinase 1 (PINK1) is a serine/threonine-protein in mitochondria that critical for mitochondrial quality control. PINK1 triggers mitophagy, selective autophagy of mitochondria, and involved regeneration. Although increments biogenesis activity are known to be crucial during differentiation, data regarding the specific role osteogenic maturation bone remodeling limited. Methods We adopted an ovariectomy model female wildtype Pink1 −/− mice. Ovariectomized mice...
Objective Bkv-miR-B1-5p, one of the microRNAs encoded by BK virus, was recently reported to be elevated in blood among patients with virus nephropathy (BKVN). Urinary exosome suggested a possible source biomarker for kidney diseases, but it unknown whether could contain viral microRNA as well human microRNAs. The aim this study evaluate urinary exosomal were expressed during replication and used diagnose BKVN transplant recipients. Materials methods In cross-sectional multicenter study, we...
Mitochondrial dysfunction is considered to be an important mediator of the pro-aging process in chronic kidney disease, which continuously increasing worldwide. Although PTEN-induced kinase 1 (PINK1) regulates mitochondrial function, its role renal aging remains unclear. We investigated association between PINK1 and aging, especially through cGAS-STING pathway, known result inflammatory phenotype. Pink1 knockout (Pink1-/- ) C57BL/6 mice senescence-induced tubular epithelial cells (HKC-8)...
Triglyceride-glucose (TyG) index has recently been established as an indicator of insulin resistance and predictive value for cardiovascular (CV) disease. However, the clinical significance TyG in patients undergoing hemodialysis remains unknown. We prospectively enrolled 759 maintenance hemodialysis. The participants were divided into tertiles based on their baseline index. Echocardiographic parameters, vascular calcification scores, several plasma biomarkers obtained compared using was...
Abstract Background Chronic kidney disease (CKD) is a prevalent condition with significant global health implications. Early detection and management are critical to prevent progression complications. Deep learning (DL) models using retinal images have emerged as potential noninvasive screening tools for CKD, though their performance may be limited, especially in identifying individuals proteinuria specific subgroups. Objective We aim evaluate the efficacy of integrating urine dipstick data...
Cytomegalovirus (CMV) infection is a frequent complication after kidney transplantation (KT) and has various effects on recipient graft survival. Although guidelines recommend anti-viral prophylaxis with ganciclovir or valganciclovir, there demand for alternative regimen CMV prevention. We investigated the of 3-month valacyclovir-based clinical outcomes in KT recipients using nationwide cohort. Overall, 2,584 from 20 transplant centers registered Korean Organ Transplantation Registry between...
Abstract Purpose Triglyceride-glucose (TyG) index is a reliable marker of insulin resistance. Although the TyG useful for identifying individuals at high risk future cardiovascular events and mortality in general population, its clinical impact on young adults remains unclear. This study aimed to investigate association between individuals. Methods We enrolled 6,667,138 aged 20-39 years who underwent Korean national health screening 2009 2012. Participants were categorized into quartiles...
Purpose. In this study, we investigated the effect of PGC1 α activators on mitochondrial fusion, fission, and autophagic quality control in renal tubular cells a diabetic environment vivo vitro. We also examined whether upregulation attenuates tubulopathy by normalizing homeostasis. Methods . HKC8 were subjected to high-glucose conditions (30 mM D-glucose). Diabetes was induced with streptozotocin (STZ, 50 mg/kg i.p. for 5 days) male C57/BL6J mice. AICAR or metformin used as activator....
Heavy proteinuria with or without features of nephrotic syndrome is associated many primary and systemic diseases. For diabetic patients, distinguishing nondiabetic renal disease (NDRD) from nephropathy (DN) important in choosing treatment modalities determining prognosis. However, clinical relevance heavy inconsistent DN assessments. This study investigated the clinicopathological outcomes NDRD type 2 patients nephrotic-range proteinuria. We enrolled 220 cases who underwent biopsy. They...
The intratubular renin-angiotensin system (RAS) is thought to play an essential role in hypertensive renal disease, but information regarding sex-related differences this limited. present study investigated sex the RAS two-kidney, one-clip (2K1C) rats. A 2.5-mm clip was placed on left artery of Sprague-Dawley rats, and rats were euthanized 3 or 5 wk after operation. Systolic blood pressure increased 2K1C both sexes significantly higher male than female antihypertensive effect not observed...
Interstitial fibrosis and tubular atrophy (IFTA) is a well-recognized risk factor for poor renal outcome in patients with diabetic kidney disease (DKD). However, noninvasive biomarker IFTA currently lacking. The purpose of this study was to identify urinary markers determine their clinical relevance as predictors prognosis.Seventy biopsy-proven isolated DKD were enrolled study. We measured multiple inflammatory cytokines chemokines by multiplex enzyme-linked immunosorbent assay these...
Abstract Recent studies indicate that urinary mitochondrial DNA (mtDNA) is predictive of ischemic AKI and related to delayed graft function (DGF) in renal transplantation. Nevertheless, the clinical implications prognostic value mtDNA kidney transplantation remain undetermined. Here, we aimed evaluate associations between cell-free parameters, including pathological findings allograft biopsy post-transplant function. A total 85 transplant recipients were enrolled, blood urine samples...
Significance Statement Tertiary lymphoid tissues (TLTs) are frequently found in transplanted kidneys, but their prevalence and clinical significance remain uncertain. Serial protocol kidney transplant biopsies without signs of rejection were collected TLTs staged according to the presence proliferating lymphocytes follicular dendritic cells. rapidly developed within 1 month after transplantation approximately half 214 patients. Advanced TLTs, defined as cells, associated with progressive...
Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that secreted from vascular cells. Elevated plasma endocan levels were shown to be associated with poor cardiovascular outcomes in patients chronic kidney disease (CKD). We investigated the clinical relevance of and urine immunoglobulin A nephropathy (IgAN).Sixty-four IgAN 20 healthy controls enrolled this study. Plasma measured. Clinical parameters, pathologic grades, renal compared among subgroups...
Most eukaryotic cells have mitochondrial networks that can change in shape, distribution, and size depending on cellular metabolic demands environments. Mitochondrial quality control is critical for various functions including energy production, redox homeostasis, intracellular calcium handling, cell differentiation, proliferation, death. Quality mechanisms within mitochondria consist of antioxidant defenses, protein control, DNA damage repair systems, fusion fission, mitophagy, biogenesis....
Background/Aims The true incidence of aristolochic acid nephropathy (AAN) is thought to be underestimated because numerous ingredients known or suspected contain (AA) are used in traditional medicine Korea. Methods We collected data on cases AAN since 1996 via a database evaluated the year development, route obtaining AA-containing herbal medicine, gender, reason for taking clinical manifestations, histological findings, phytochemical analysis, and prognosis patients with AAN. Results Data...
Systemic inflammation has been proposed as a relevant factor of vascular remodeling and dysfunction. We aimed to identify circulating inflammatory biomarkers that could predict future arteriovenous fistula (AVF) dysfunction in patients undergoing hemodialysis. A total 282 hemodialysis were enrolled this prospective multicenter cohort study. Plasma cytokine levels measured at the time data collection. The primary outcome was occurrence AVF stenosis and/or thrombosis requiring percutaneous...
Abstract Objective Screening for chronic kidney disease (CKD) requires an estimated glomerular filtration rate (eGFR, mL/min/1.73 m2) from a blood sample and proteinuria level urinalysis. We developed machine-learning models to detect CKD without collection, predicting eGFR less than 60 (eGFR60 model) or 45 (eGFR45 using urine dipstick test. Materials Methods The electronic health record data (n = 220 018) obtained university hospitals were used XGBoost-derived model construction. variables...
Metabolic syndrome (MetS) is prevalent in patients with end-stage kidney disease, and transplantation expected to modify the metabolic status. However, whether changes status at time of affect recipient outcomes remains unclear.We analyzed 4187 recipients registered a nationwide prospective cohort from 2014 2020. MetS was defined as presence three or more components syndrome. Patients were classified based on pre- post-transplant status: MetS-free, MetS-developed, MetS-recovered...