A5062400242- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
- Gout, Hyperuricemia, Uric Acid
- Nutrition and Health in Aging
- Parathyroid Disorders and Treatments
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Microbial metabolism and enzyme function
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Potassium and Related Disorders
- Immune Cell Function and Interaction
- Abdominal vascular conditions and treatments
- Cardiac Imaging and Diagnostics
- Liver Disease and Transplantation
- Biomedical Research and Pathophysiology
- Extracellular vesicles in disease
- Bone health and treatments
- Muscle and Compartmental Disorders
- Hormonal Regulation and Hypertension
- Body Composition Measurement Techniques
Gangnam Severance Hospital
2015-2024
Yonsei University
2015-2024
Severance Hospital
2014-2024
Chungnam National University
2023
Korea Institute of Science & Technology Information
2010-2023
Seoul St. Mary's Hospital
2020-2021
Catholic University of Korea
2015-2021
Korea University Medical Center
2020
GL PharmTech (South Korea)
2019
Ewha Womans University
2004-2016
We recently demonstrated the use of in vitro expanded kidney-derived mesenchymal stem cells (KMSC) protected peritubular capillary endothelial acute renal ischemia-reperfusion injury. Herein, we isolated and characterized microparticles (MPs) from KMSC. investigated their biologic effects on human vivo renoprotective MPs were supernatants KMSC cultured anoxic conditions serum-deprived media for 24 hours. KMSC-derived presence several adhesion molecules normally expressed membranes, such as...
Microparticles (MPs) derived from kidney-derived mesenchymal stem cells (KMSCs) have recently been reported to ameliorate rarefaction of peritubular capillaries (PTC) in ischemic kidneys via delivery proangiogenic effectors. This study aimed investigate whether KMSC-derived MPs show anti-fibrotic effects by ameliorating endothelial-to-mesenchymal transition (EndoMT) human umbilical vein endothelial (HUVEC) vitro and preserving PTC with unilateral ureteral obstruction (UUO) vivo. isolated the...
Background. Novel, biocompatible peritoneal dialysis (PD) solutions have become available in recent years. In 2001, low glucose degradation products (GDP), neutral pH became commercially Korea. To date, there are no reports regarding the large scale adoption of these clinical practice and what, if any, impact on patient outcomes.
Long-term peritoneal dialysis (PD) is associated with the development of various structural and functional changes to membrane when bioincompatible conventional fluids (PDFs) are used. In this study, we looked at patients that were treated PDFs then changed novel biocompatible a neutral pH low concentration glucose degradation products (GDPs) investigate whether change could result in arrest or reversal deterioration.In an open label, randomized prospective trial, clinical effects very GDPs...
Continuous ambulatory peritoneal dialysis (CAPD) is an established treatment for end-stage renal disease (ESRD). We investigated the outcome of CAPD over a period 25 years at our institution.CAPD has been performed in 2301 patients years. After excluding with less than 3 months follow-up and missing data, we evaluated 1656 who started between November 1981 December 2005. Data sex, age, primary disease, comorbidities, duration, cause death, technique failure were collected. also examined data...
Tyrosine and serine/threonine signal-transduction pathways influence many aspects of cell behavior, including the spatial temporal regulation actin cytoskeleton. However, little is known about how input from diverse tyrosine kinases integrated to control Rho protein crosstalk remodeling, which are critically important in podocyte health disease. Here we unveil proteolytically-regulated, organizing synaptopodin as a coincidence detector versus phosphorylation. We show that duel for stability...
Abstract Background Online haemodiafiltration (OL-HDF) may improve middle molecular clearance in contrast to conventional haemodialysis (HD). However, OL-HDF requires higher convective flows and cannot sufficiently remove large molecules. This study evaluated the efficacy of a medium cut-off (MCO) dialyser removing uraemic toxins compared it with that high-flux (HF) dialysers HD predilution OL-HDF. Methods Six clinically stable patients without residual renal function were investigated....
Potassium is abundant in the ICF compartment body and its excretion primarily depends on renal (about 90%), to a lesser extent 10%) colonic excretion. Total potassium approximated 50mmol/kg weight 2% of total ECF 98% it intracellular compartment.Dyskalemia frequent electrolyte imbalance observed among maintenance hemodialysis patients. In case hyperkalemia, frequently "a silent potential life threatening imbalance" patients with ESRD under hemodialysis. The prevalence hyperkalemia HD was...
Background: The number of elderly people on dialysis is increasing rapidly. Fluid overload and malnutrition status are serious problems in patients. We aimed to compare the hydration nutritional through bioimpedance analysis (BIA) between young hemodialysis (HD) patients analyze risk factors related fluid these Method: conducted a cross-sectional study, which 82 HD (males 42, mean age 58.7±12.9 years) were enrolled. collected different types data: laboratory data, such as serum creatinine,...
Allergic contact dermatitis is a common diagnosis in eyelid dermatitis. Sensitization to metals prevalent and colour cosmetic products are frequently suspected as the source of metal exposure.To investigate allergens for assess contents eye shadow products.Data were collected department dermatology Ewha Womans University hospital from December 1998 February 2014. A total 983 patients patch tested during period 67 had among them. To examine elements eyes, randomly selected 10 shadows...
Background. Cardiovascular disease is the main cause of mortality in end-stage renal (ESRD) patients. Recent studies have indicated that non-traditional risk factors such as endothelial dysfunction (ED), chronic inflammation and protein-energy wasting (PEW) may contribute significantly to increased cardiovascular among dialysis To further ascertain this association, we carried out a cross-sectional assessment nutritional status, inflammatory markers peritoneal (PD)
Recently, the pathogenic role of uric acid (UA) in both systemic metabolic and atherosclerotic diseases has been investigated. We sought to determine independent correlation between serum UA levels coronary artery calcification, as a marker subclinical atherosclerosis. A total 4188 individuals without prior disease or urate-deposition were included. All participants underwent multidetector computed tomography (MDCT) for evaluation calcification (CAC) during their health check-ups. The...
Hyperuricemia is a risk factor for cardiovascular disease and associated with increased arterial stiffness in high-risk populations. However, given the possible sex-related differences prevalence of hyperuricemia, association between elevated serum uric acid (SUA) level has yielded conflicting results. We investigated relationship SUA asymptomatic healthy subjects who underwent health examination. Subjects comprehensive examination were enrolled. After exclusion extensive confounding...
Interstitial fibrosis and tubular atrophy (IFTA) is a well-recognized risk factor for poor renal outcome in patients with diabetic kidney disease (DKD). However, noninvasive biomarker IFTA currently lacking. The purpose of this study was to identify urinary markers determine their clinical relevance as predictors prognosis.Seventy biopsy-proven isolated DKD were enrolled study. We measured multiple inflammatory cytokines chemokines by multiplex enzyme-linked immunosorbent assay these...
Sclerosing encapsulating peritonitis (SEP) is a rare yet serious complication in patients with continuous ambulatory peritoneal dialysis (CAPD). Incidence and prevalence of this syndrome have been defined some large populations few single-centre experiences, but there no satisfactory estimate the comparative incidence related SEP. The pathogenesis SEP still remains uncertain, could be various causative factors. diagnosis based on clinical suspicion confirmed radiologic and/or pathologic...
The aim of this study was to evaluate the evolution lupus activity in end-stage renal disease (ESRD) patients due nephritis and determine long-term prognosis. We reviewed clinical courses 45 with ESRD systemic erythematosus (SLE). analyzed course SLE following onset ESRD, special attention serological manifestations, survival time on dialysis, transplantation outcome. Disease measured using Activity Index (SLEDAI). Of patients, 21 were being treated hemodialysis (HD), 11 undergoing...
Sclerosing encapsulating peritonitis (SEP) is a rare but serious complication in patients with continuous ambulatory peritoneal dialysis (CAPD), and characterized by progressive, intra-abdominal, inflammatory process resulting the formation of sheets new fibrous tissue, which cover, bind, constrict viscera, thereby compromising motility bowel.No satisfactory estimate available on comparative incidence related SEP pathogenesis still remains uncertain.Although recent therapeutic approaches...