A5090275275- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Acute Kidney Injury Research
- Cardiovascular Health and Disease Prevention
- Renal function and acid-base balance
- Cardiovascular Function and Risk Factors
- Potassium and Related Disorders
- Nutrition and Health in Aging
- Sodium Intake and Health
- Iron Metabolism and Disorders
- Liver Disease Diagnosis and Treatment
- Renal and Vascular Pathologies
- Sepsis Diagnosis and Treatment
- Nutritional Studies and Diet
- Erythropoietin and Anemia Treatment
- Heart Failure Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Neurological and metabolic disorders
- Folate and B Vitamins Research
- Biomedical Research and Pathophysiology
Yonsei University
2016-2025
Severance Hospital
2014-2025
Yonsei University Health System
2014-2021
Sunchon National University
2021
The Korean Society of Nephrology
2020-2021
Kidney Research UK
2017-2020
University of Miami
2013-2019
Doosan (South Korea)
2019
Ewha Womans University
2007-2017
National Health Insurance Service
2017
Abstract Kidney tubular cell death induced by transforming growth factor-β1 (TGF-β1) is known to contribute diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent apoptosis and caspase-1-dependent pyroptosis are also involved in under conditions. Recently, ferroptosis, an atypical form iron-dependent death, was reported cause kidney disease, including acute injury. Ferroptosis primed lipid peroxide accumulation through the cystine/glutamate antiporter system X c − (xCT)...
Abstract Introduction A potential independent association was recently demonstrated between high red blood cell distribution width (RDW) and the risk of all-cause mortality in critically ill patients, although mechanism underlying this relationship remains unclear. Little is known about impact changes RDW may have on survival patients. Therefore, we investigated prognostic significance during hospital stay patients with severe sepsis or septic shock. Methods We prospectively enrolled 329 who...
Next generation exosome-based therapy can protect against systemic inflammation and sepsis-induced death.
The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), albuminuria (A). KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease), which is a prospective cohort study, enrolls subjects with stages 1 to 5 (predialysis). Nine nephrology centers major university hospitals throughout Korea will enroll approximately 2,450 adults over 5-year period from 2011 2015. participating...
A potential independent association was recently demonstrated between high red blood cell distribution width (RDW) and the risk of all-cause mortality in patients with cardiovascular disease, although mechanism remains unclear. However, there have been no reports on relationship RDW acute kidney injury (AKI) treated continuous renal replacement therapy (CRRT). In this study, we assessed whether associated AKI CRRT treatment intensive care unit (ICU). We enrolled 470 who were at Yonsei...
Mean platelet volume (MPV) is suggested as an index of inflammation, disease activity, and anti-inflammatory treatment efficacy in chronic inflammatory disorders; however, the effect MPV on sepsis mortality remains unclear. Therefore, we investigated whether change between hospital admission 72 hours (ΔMPV72h-adm) predicts 28-day severe and/or septic shock.We prospectively enrolled 345 patients admitted to emergency department (ED) who received standardized resuscitation (early goal-directed...
Background and Aims Mesangial C3 deposition is frequently observed in patients with IgA nephropathy (IgAN). However, the role of complement pathogenesis or progression IgAN uncertain. In this observational cohort study, we aimed to identify clinical implications circulating levels mesangial investigate their utility as predictors renal outcomes IgAN. Methods A total 343 biopsy-proven were enrolled between January 2000 December 2008. Decreased serum level (hypoC3) was defined <90 mg/dl. The...
Kidney fibrosis is the histologic manifestation of CKD. Sustained activation developmental pathways, such as Notch, in tubule epithelial cells has been shown to have a key role development. The molecular mechanism Notch-induced fibrosis, however, remains poorly understood. Here, we show that, that expression peroxisomal proliferation g-coactivator (PGC-1α) and fatty acid oxidation-related genes are lower mice expressing active Notch1 tubular (Pax8-rtTA/ICN1) compared littermate controls....
Diabetic kidney disease (DKD) remains the most common cause of end-stage despite multifactorial intervention. We demonstrated that increased cholesterol in association with downregulation ATP-binding cassette transporter ABCA1 occurs normal human podocytes exposed to sera patients type 1 diabetes and albuminuria (DKD(+)) when compared diabetic normoalbuminuria (DKD(-)) similar duration lipid profile. Glomerular was confirmed biopsies from early DKD (n = 70) living donors 32). Induction...
Diabetic kidney disease (DKD) is the most common cause of ESRD in United States. Podocyte injury an important feature DKD that likely to be caused by circulating factors other than glucose. Soluble urokinase plasminogen activator receptor (suPAR) a factor found elevated serum patients with FSGS and causes podocyte αVβ3 integrin-dependent migration vitro. Furthermore, integrin activation occurs association decreased podocyte-specific expression acid sphingomyelinase-like phosphodiesterase 3b...
Subclinical hypothyroidism is not a rare condition, but the use of thyroid hormone to treat subclinical an issue debate.This study was undertaken investigate impact therapy on changes in estimated glomerular filtration rate (eGFR) patients with stage 2-4 chronic kidney disease.A total 309 were included final analysis.The eGFR over time compared between and without replacement using linear mixed model. Kaplan-Meier curves constructed determine effect renal outcome, reduction by 50%, or...
Subclinical hypothyroidism (SCH) is not a rare condition in females, the elderly, or patients with chronic kidney disease (CKD). Even though previous studies have demonstrated that thyroid hormone replacement therapy (THRT) improves cardiac function and dyslipidemia SCH, it remains unclear as to whether THRT can improve renal CKD SCH. This study investigated impact of on changes estimated glomerular filtration rates (eGFR) this patient population.A total 113 SCH who were treated L-thyroxine...
Nephrotic syndrome (NS) is a rare manifestation of IgA nephropathy (IgAN). Clinical characteristics and long-term outcomes this condition have not yet been explored.A multicenter observational study was conducted between January 2000 September 2010 in 1076 patients with biopsy-proven IgAN from four medical centers Korea. The primary outcome doubling the baseline serum creatinine concentration.Of patients, 100 (10.2%) presented NS; complete remission (CR), partial (PR), no response (NR)...
Progressive renal failure causes uremia-related immune dysfunction, which features a chronic inflammatory milieu. Given the central role of end-stage disease (ESRD)-related dysfunction in pathogenesis cardiovascular diseases (CVDs), much attention has been focused on how uremic toxins affect cellular immunity and mechanisms underlying atherosclerosis ESRD patients. Here, we investigated characteristics monocytes CD4+ T cells patients responses induced by indoxyl sulfate (IS), key toxin,...
Abstract Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report SMPDL3b excess, as observed in podocytes diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival signaling by interfering with isoforms binding to caveolin-1 the PM. excess affects production of active sphingolipids resulting decreased ceramide-1-phosphate (C1P) content human vitro and cortexes db/db mice vivo....
The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney fibrosis. However, it unknown whether PGC-1α, a key biogenesis regulator, modulates in injury. Primary renal tubular epithelial cells (RTECs) were isolated from C57BL/6 mice. inflammasome, dynamics morphology, oxidative stress, cell injury markers examined RTECs treated TGF-β1 with or without Ppargc1a plasmid, PGC-1α activator (metformin), siPGC-1α. In vivo, adenine-fed unilateral ureteral obstruction (UUO)...