The association between sarcopenia and cardiovascular disease (CVD) in elderly people has not been adequately assessed. aim of this study was to investigate whether CVD is more prevalent subjects with independent other well-established risk factors older Korean adults.This utilized the representative population data from Korea National Health Nutrition Examination Survey (KNHANES) which conducted 2009. Subjects than 65 years age appendicular skeletal muscle mass (ASM) determined by dual...

A discrepancy exists with regard to the effect of smartphone applications (apps) on weight reduction due several limitations previous studies. This is a retrospective cohort study, aimed investigate effectiveness app in obese or overweight individuals, based complete enumeration study that utilized clinical and logging data entered by Noom Coach users between October 2012 April 2014. total 35,921 participants were included analysis, whom 77.9% reported decrease body while they using (median...

Diabetic patients with a long disease duration usually accompanied complication such as diabetic retinopathy, but in some had no complication.We analyzed differences plasma metabolites according to the presence or absence of retinopathy (DR) type 2 (T2D) ≥ 15 years.A cohort 183 T2D was established. Their biospecimens and clinical information were collected accordance guidelines National Biobank Korea, Korean Diabetes Association. DR phenotypes subjects verified by ophthalmologic specialists....

Abstract The effect of diabetes distress on glycemic control and its association with complications is still poorly understood. We aimed to study the clinical features patients high distress, focusing changes in risk diabetic complications. From Korean National Diabetes Program data, we investigated 1862 individuals type 2 mellitus (T2DM) who completed complication studies version Problem Areas Survey (PAID-K). A total score PAID-K ≥ 40 was considered indicative distress. Individuals (n =...

Mitochondrial oxidative damage is thought to play a key role in pancreatic β-cell failure the pathogenesis of type 2 diabetes. Despite this, potential mitochondria-targeted antioxidants protect β-cells against stress has not yet been studied. Therefore, we investigated if such as RINm5F and HIT-T15 cells under glucotoxic glucolipotoxic conditions. When were incubated these conditions, expression levels mitochondrial electron transport chain complex subunits, antioxidant enzymes (such MnSOD...

Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), paralog of adiponectin, may play an important role in the regulation glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), multifunctional protein with antioxidant anti-inflammatory properties, is associated insulin resistance metabolic syndrome. We examined circulating CTRP-3 PEDF concentrations 345 subjects diverse tolerance statuses. Furthermore, we...

Abstract Background Although an association between low-level environmental heavy metal exposure and the incidence of metabolic syndrome (MS) has been hypothesized, little research on this topic conducted a population-wide level. Methods We analyzed MS status whole blood lead, mercury, cadmium, manganese, creatinine-adjusted urine arsenic concentrations in 1,405 subjects, ≥ 20 years age, who were registered for Korea National Health Nutrition Examination Survey, 2008. Results Various...

We developed for the first time a smartphone application designed diabetes self-management in Korea and registered patent relevant algorithm. also investigated user satisfaction with change related self-care activities after using application.We conducted questionnaire survey on volunteers who were application. Ninety subjects responded to between June 2012 March 2013. A modified version of Summary Diabetes Self-Care Activities (SDSCA) was used this study.The results exhibited mean subject...

The aim of this study was to assess the glucose-lowering and lipid-modifying effects, safety profile lobeglitazone, a novel peroxisome proliferator-activated receptor- γ agonist, compared placebo as monotherapy in patients with type 2 diabetes.In 24-week, multicenter, randomized, double-blind, parallel-group, controlled study, 173 were randomly assigned (a 2∶1 ratio) lobeglitazone 0.5 mg (n=115) or matching (n=58) orally once daily. primary endpoint change glycated hemoglobin (HbA1c) from...

We aimed to evaluate the effects of carnitine-orotate complex in patients with nonalcoholic fatty liver disease (NAFLD) and diabetes.Eight hospitals Korea participated this randomized, controlled, double-blind trial diabetes NAFLD. Seventy-eight were randomly assigned a 1:1 ratio receive (824 mg, three times daily) or matching placebo. The primary study outcome was decline alanine aminotransferase (ALT) normal range. Secondary outcomes change ALT, radiological hepatic steatosis, parameters...

Abstract During the progression of Type 2 diabetes, glucose toxicity is likely to contribute importantly progressive beta cell failure. Oxidative stress an important aspect in pancreatic cells, and reducing sugars, such as 2‐deoxy‐D‐ribose (dRib), produce reactive oxygen species. Furthermore, many biological properties flavonoids are be related their antioxidant free‐radical scavenging abilities. Accordingly, present study, we investigated whether kaempferol (a flavonol) protects cells from...

Hyperglycemia that does not satisfy the diagnostic criteria for diabetes mellitus (DM) is generally called prediabetes (preDM). The global prevalence of preDM has been increasing progressively in past few decades, and it established status a strong risk factor DM cardiovascular disease. Currently, classified into two subtypes: impaired fasting glucose tolerance. regarded as an independent clinical entity, but only others. In this article, we review various aspects terms working definition,...

The Korean National Diabetes Program (KNDP) cohort study is performing an ongoing large-scale prospective multicenter investigation to discover the pathogenesis of type 2 diabetes in patients. This was performed examine prevalence chronic complications patients with among those registered KNDP within past 4 years.This between June 2006 and September 2009 at 13 university hospitals included 4,265 participants. Among participants, crude microvascular macrovascular diseases checked for...

Glucose toxicity contributes to progressive β-cell failure and the development of overt diabetes. Oxidative stress is an important aspect glucose in pancreatic β-cells. We investigated whether flavonoid apigenin protects β-cells from 2-deoxy-D-ribose (dRib)-induced oxidative cell damage. HIT-T15 were cultured with or without presence dRib. Time- dose-dependent viability was monitored using a counting kit (CCK-8), while induction apoptosis analyzed death enzyme-linked immunosorbent assay...

The epidemiological literature suggests that insulin resistance, hyperinsulinemia, and increased levels of insulin-like growth factors place patients with type 2 diabetes mellitus (T2DM) at greater risk cancer. association between cancer incidence the use antidiabetic medications in T2DM has been recently examined. There have conflicting reports regarding an metformin risk. aim this study was to investigate relationship Koreans T2DM. Data from Korean National Diabetes Program (KNDP,...

Yang I, Park S, Ryu M, Woo J, Kim Y, Choi Y. Characteristics of gsp-positive growth hormone-secreting pituitary tumors in Korean acromegalic patients. Eur J Endocrinol 1996;134: 720–6. ISSN 0804–4643 A subset human hormone (GH)-secreting contains the gsp oncogene that encodes an activation mutation α-subunit stimulatory GTP-binding protein (G s α). This study was undertaken to investigate frequency GH-secreting patients and elucidate clinical characteristics these endocrine testing. Direct...

Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor, its polymorphisms are associated with proliferative diabetic retinopathy (PDR) macular edema.We investigated the contributions of VEGF gene to nonproliferative (NPDR) as well PDR.In this study we compared variants in sample Korean type 2 diabetes patients without (DR) healthy controls. Of patients, 145 had PDR, 108 NPDR, 134 no (noDR). They were all duration matched. Samples genotyped for...

It has been suggested that there is an association between environmental, low-level arsenic exposure and the risk of diabetes mellitus (DM), but little research conducted. Here, glucose tolerance status urinary creatinine adjusted total concentrations were analyzed in 3,602 subjects ≥ 20 yr age who registered for Korea National Health Nutrition Examination Survey, 2008-2009. Various demographic parameters associated with concentrations. After adjusting these variables, DM significantly...

Diabetes ProgramWe analyzed the direct medical costs for Korean patients with type 2 diabetes according to of complications and number microvascular complications.We associated in 3,125 patients.These data were obtained from National Program (KNDP), a large, ongoing, prospective cohort study that began 2005.The cost prospectively collected, using an electronic database, KNDP at six hospitals.The 1 yr enrollment study.Among patients, 918 had no vascular complications; 1,883 only; 51...

Diabet. Med. 29, 1003–1010 (2012) Abstract Aims A causal relationship between vitamin D deficiency and the incidence of diabetes mellitus has been suggested, but little research conducted on Korean population. Methods We analysed glucose tolerance status serum 25‐hydroxyvitamin concentrations in 12 263 subjects > 19 years old who were registered for Korea National Health Nutrition Examination Survey, 2008–2009. Results Various demographic variables such as gender, age, season, resident...