Background Protein-energy wasting is common in patients with end-stage kidney disease. However, few studies have examined the relationship between early stages of chronic disease (CKD) and sarcopenia. Methods We conducted a cross-sectional study based on data Korea National Health Nutrition Examination Survey, 2008–2011. In total, 11,625 subjects aged 40 years or older who underwent dual-energy X-ray absorptiometry were analyzed. Sarcopenia was defined values appendicular skeletal muscle...

Nephrotic syndrome (NS) is a rare manifestation of IgA nephropathy (IgAN). Clinical characteristics and long-term outcomes this condition have not yet been explored.A multicenter observational study was conducted between January 2000 September 2010 in 1076 patients with biopsy-proven IgAN from four medical centers Korea. The primary outcome doubling the baseline serum creatinine concentration.Of patients, 100 (10.2%) presented NS; complete remission (CR), partial (PR), no response (NR)...

We recently demonstrated the use of in vitro expanded kidney-derived mesenchymal stem cells (KMSC) protected peritubular capillary endothelial acute renal ischemia-reperfusion injury. Herein, we isolated and characterized microparticles (MPs) from KMSC. investigated their biologic effects on human vivo renoprotective MPs were supernatants KMSC cultured anoxic conditions serum-deprived media for 24 hours. KMSC-derived presence several adhesion molecules normally expressed membranes, such as...

Loss of residual renal function (RRF) contributes to anaemia, inflammation and malnutrition is also a strong predictor mortality in continuous ambulatory peritoneal dialysis (CAPD) patients. However, the role RRF on peritonitis not yet clearly established. This study aimed evaluate effect development peritonitis.Study subjects were 204 end-stage disease (ESRD) patients who started PD from January 2000 December 2005. Biochemical clinical data within 1 month commencement considered as...

Long-term peritoneal dialysis (PD) is associated with the development of various structural and functional changes to membrane when bioincompatible conventional fluids (PDFs) are used. In this study, we looked at patients that were treated PDFs then changed novel biocompatible a neutral pH low concentration glucose degradation products (GDPs) investigate whether change could result in arrest or reversal deterioration.In an open label, randomized prospective trial, clinical effects very GDPs...

Previous studies have shown that mineralocorticoid receptor (MCR) blocker reduces proteinuria in diabetic nephropathy (DN), but the role of aldosterone podocyte injury has never been explored DN. This study was undertaken to elucidate whether a local system existed podocytes and examine its apoptosis under conditions. In vitro, immortalized were exposed 5.6 mM glucose (NG), NG + 24.4 mannitol, 30 (HG) with or without 10(-7) M spironolactone (SPR). vivo, 32 Sprague-Dawley rats injected...

Recent studies have demonstrated that an inflammatory mechanism contributes to the pathogenesis of diabetic nephropathy (DN). It is also known colchicine (Col) can prevent various renal injuries via its anti-inflammatory action. However, effect on DN has never been explored. This study was undertaken elucidate inflammation and extracellular matrix accumulation in DN. In vivo, 64 rats were injected with diluent (C; n = 32) or streptozotocin intraperitoneally (DM, 32). Sixteen from each group...

Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine that plays an important role in the recruitment of macrophages. Although previous studies have demonstrated importance MCP-1 pathogenesis diabetic nephropathy (DN) terms inflammation, and its receptor (C-C 2; CCR2) extracellular matrix (ECM) accumulation under conditions has been largely unexplored. This study was undertaken to investigate functional MCP-1/CCR2 system high glucose-induced ECM (fibronectin type IV collagen)...

During continuous renal replacement therapy (CRRT), anticoagulation of the extracorporeal circuit is required. The aim this study was to assess efficacy and safety nafamostat mesilate, a serine protease inhibitor, compared with heparin. We retrospectively studied 222 patients treated CRRT in intensive care unit (ICU). Clinical filter-related data were extracted. reviewed medical records CRRT. Initial methods 56 heparin 25 mesilate; 10 received infused systemically, 131 without...

Dysregulated microRNAs (miRNAs) can contribute to cancer development by leading abnormal proliferation of cells, apoptosis, and differentiation. Although several miRNAs that are related gastric have been identified, the reported results inconsistent. The aim this study was determine miRNA expression profiles validate up- down-regulated in cancer.We evaluated 34 primary tissues paired adjacent nontumorous tissues. Total RNA extracted, low-molecular-weight RNAs (<200 nucleotides) were isolated...

Previous in vitro studies suggest that the p38 MAPK pathway may be involved pathogenesis of diabetic nephropathy, but consequences inhibition have not been well elucidated (DM) glomeruli. This study was undertaken to investigate effect inhibitor, FR167653, on fibronectin expression and apoptosis DM glomeruli high-glucose-stimulated mesangial cells (MC). In vivo, 32 Sprague-Dawley rats were injected with diluent (control, N = 16) or streptozotocin intraperitoneally (DM, 16). Eight from each...

Clostridium difficile infection. The mortality rate of fulminant C. infection is reported to be as high 50%. Fecal microbiota transplantation a highly effective treatment in patients with recurrent or refractory However, there are few published articles on the use such for Here, we report patient toxic megacolon complicated by who was treated successfully fecal mi-crobiota transplantation. (Gut Liver, 2015;9:247-250).

Although icodextrin solution has been highlighted in the fluid management compared to glucose-based solutions, proof of a beneficial effect on residual renal function (RRF) is lacking. We conducted multicenter prospective randomized controlled open-label trial investigate whether can preserve RRF. One hundred patients with urine volume ≥750 mL/day from 8 centers Korea were randomly assigned receive 1 exchange for ≥8 hour-dwell time and 2 exchanges 1.5% biocompatible neutral pH or ≥2.5%...

Background The impact of low-normal hemoglobin (Hb) levels and anemia on the risk end-stage renal disease (ESRD) in general populations has rarely been examined. Methods 510,620 Korean adults aged 40–80 years without known chronic kidney (CKD) underwent health examinations during 2002–2003 were followed-up until 2013. Incidence ESRD was identified by hospital discharge clinical visit records. Results During a mean follow-up 10.5, 575 women 1047 men diagnosed with ESRD. Lower Hb associated an...

Of a large body of literature reporting clinical outcomes for patients maintained on peritoneal dialysis (PD), most publications have focused relatively short-term results. Few reports long-term survival in PD patients. Here, we present our experience with patient and further analyses the trends demographics 2301 end-stage renal disease (ESRD) treated continuous ambulatory (CAPD) during 25-year period (1981 – 2005) at institute. Outcomes were analyzed 1656 patients, excluding those younger...

Urinary biomarkers of acute kidney injury (AKI) have been revealed recently to be useful for prior prediction AKI.However, it is unclear whether these urinary can also detect recovery from established AKI.Urinary biomarkers, including neutrophil gelatinaseassociated lipocalin (NGAL) and cystatin C, were measured every 2 days 8 in 66 patients with AKI.At day 0, there no significant differences plasma creatinine, BUN, urine C between AKI the (n = 33) non-recovery groups.Plasma creatinine...

Background. Skin hyperpigmentation in end-stage renal disease (ESRD) patients has been attributed to the accumulation of middle-molecular-weight (MMW) substances. Although an MMW mechanism suggests that may be improved by high-flux haemodialysis (HF-HD) and haemodiafiltration (HDF), this possibility not explored. In present study, we investigated impact different dialysis modalities on skin colour HD patients.

Abstracts Background Hemodialysis (HD) patients have multiple causes of immune dysfunction and poor response to influenza vaccination. We investigated the antibody rate a pandemic H1N1/2009 vaccination clinical parameters influencing induction responses in HD patients. Methods A total 114 were vaccinated with monovalent adjuvanted H1N1 inactivated vaccine. Titers neutralizing antibodies evaluated by hemagglutination inhibition (HI) assay at pre- 4 weeks after Seroconversion was defined as...

Objectives Significant weight gain is a potential problem in most patients starting peritoneal dialysis (PD); however, few studies have explored the clinical effects of increased body (BW) these patients. We evaluated effect excess during first year after PD on residual renal function (RRF). Methods A total 148 incident were analyzed longitudinal observational study. The mean duration follow-up was 23.8 months. RRF measured at baseline (within 1 month PD) and thereafter 6-month intervals for...

Uremic pruritus is common in patients with chronic kidney disease (CKD). The retention of uremic solutes thought to be associated pruritus. Meanwhile, activation protease-activated receptor-2 (PAR-2) has been suggested play an important role present study was performed investigate the effects on expression PAR-2 skin.Indoxyl sulfate (IS), p-cresol (PC), and sera from CKD were used stimulate normal human epidermal keratinocytes (NHEKs). Also, NHEKs additionally pretreated soybean trypsin...

Hypokalemia is a frequent problem in patients on continuous ambulatory peritoneal dialysis (CAPD) and affected by multiple factors. To evaluate factors associated with hypokalemia, we studied 68 maintenance CAPD treatment for at least six months. In univariate analysis, hypokalemia were older age the presence of diabetes mellitus. Serum albumin, calcium-phosphate product, triglyceride, body mass index, protein nitrogen appearance, lean assessed creatinine kinetics significantly lower as...