A5101972327- Radiation Therapy and Dosimetry
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Gastrointestinal Tumor Research and Treatment
- Immune cells in cancer
- CAR-T cell therapy research
- Genetic factors in colorectal cancer
- Food Quality and Safety Studies
- Minimally Invasive Surgical Techniques
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Nutrition, Health and Food Behavior
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Metastasis and carcinoma case studies
- Bariatric Surgery and Outcomes
Catholic University of Korea
2014-2024
Daejeon St. Mary's Hospital
2010-2024
Versus Arthritis
2024
Bristol-Myers Squibb (United States)
2024
Sequoia Hospital
2024
Bristol-Myers Squibb (Germany)
2023
Korea Institute of Radiological and Medical Sciences
2022
Unity Hospital
2022
Unity Health System
2022
Seoul St. Mary's Hospital
2018-2020
The current recommendation of ribavirin dose for the treatment chronic hepatitis C is based on study results Western patients, and might not be optimal Korean patients because different body frames.A total 163 treatment-naive genotype 1 who received combination therapy with pegylated interferon a-2a were reviewed.Under dosing, only 49% started 13-15mg/kg (targeted dose), while 45% 6% =16mg/kg <13mg/kg, respectively. Patients higher experienced more modification during (55%, 31% 11% =16mg/kg,...
We have recently described two independent mouse models in which the administration of diphtheria toxin (DT) leads to specific depletion regulatory T cells (Tregs) due expression DT receptor-enhanced GFP under control Foxp3 promoter. Both develop severe autoimmune disorders when Foxp3(+) Tregs are depleted. Those findings were challenged a recent study published this journal suggesting epithelial as cause for disease development. By using genetic, cellular, and immunohistochemical...
OX40, a receptor transiently expressed by T cells upon antigen recognition, is associated with costimulation of effector and impairment regulatory T-cell function. This first-in-human study evaluated MOXR0916, humanized effector-competent agonist IgG1 monoclonal anti-OX40 antibody.Eligible patients locally advanced or metastatic refractory solid tumors were treated MOXR0916 intravenously once every 3 weeks (Q3W). A 3+3 dose-escalation stage (0.2-1,200 mg; n = 34) was followed expansion...
101 Background: OX40 is a co-stimulatory receptor that transiently expressed by T cells upon antigen recognition. In murine models, engagement an agonist anti-OX40 antibody can promote durable tumor regression associated with co-stimulation of effector and reduction regulatory cells. This dual mechanism action predicted to complement the activity PD-L1 blockade. MOXR0916 humanized effector-competent IgG1 monoclonal (mAb) targets atezolizumab engineered mAb PD-L1. Methods: A Phase I,...
Strong evidence is lacking as no confirmatory randomized controlled trials (RCTs) have compared the efficacy of totally laparoscopic distal gastrectomy (TLDG) with laparoscopy-assisted (LADG). The authors performed an RCT to confirm if TLDG different from LADG.
Recent development of personal sequencers for extensive mutation analysis and bead array technology comprehensive DNA methylation have made it possible to obtain integrated pictures genetic epigenetic alterations on the same set cancer samples. Here, we aimed establish such gastric cancers (GCs). Comprehensive 30 GCs revealed that number aberrantly methylated genes was highly variable among individual GCs. Extensive 55 known cancer-related 19 had 24 somatic mutations eight different (CDH1,...
Congenital torticollis is a condition that results in the deviation of child's head to one side, with accompanying limitation range motion neck. Although multiple etiologies, most common primary idiopathic resulting fibrosis and scarring sternocleiodomastoid muscle. The clinical experience at Variety Center for Craniofacial Rehabilitation Institute Reconstructive Plastic Surgery New York University Medical from 1992 1997 was retrospectively reviewed. Clinical records, standardized medical...
Abstract Immunotherapy with checkpoint inhibitors has proved to be highly effective, durable responses in a subset of patients. Given their encouraging clinical activity, are increasingly being tested trials combination chemotherapy. In many instances, there is little understanding how chemotherapy might influence the quality immune response generated by inhibitors. this study, we evaluated impact alone or anti–PD-L1 responsive syngeneic tumor model. Although multiple classes treatment...
Xanthogranulomatous cholecystitis (XGC) mimics early-stage gallbladder (GB) cancer with wall thickening on computed tomography (CT), both clinically and radiologically. Preoperative differentiation of XGC from GB is important for selecting the most appropriate surgical management. Therefore, we evaluated clinical features multidetector CT (MDCT) findings to determine whether it can be distinguished cancer.We retrospectively 25 patients 56 wall-thickening type T1- T2-stage cancer, where all...
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are classified into following four histopathologic subtypes: gastric, intestinal, pancreatobiliary, and oncocytic. However, clinicopatholgic characteristics IPMN subtypes have not been fully clarified. Recently, a subgroup classification minimally invasive intraductal carcinomas (MI-IPMCs) was suggested in contrast to overt carcinoma from IPMCs (IC-IPMCs). The purpose this study determine whether or pathologic subtype can...
Dysregulated microRNAs (miRNAs) can contribute to cancer development by leading abnormal proliferation of cells, apoptosis, and differentiation. Although several miRNAs that are related gastric have been identified, the reported results inconsistent. The aim this study was determine miRNA expression profiles validate up- down-regulated in cancer.We evaluated 34 primary tissues paired adjacent nontumorous tissues. Total RNA extracted, low-molecular-weight RNAs (<200 nucleotides) were isolated...
Acute hepatic failure (AHF) is one of the most serious complications transcatheter arterial chemoembolization (TACE). The aims this study were to investigate risk factors AHF after TACE and establish a predictive model for AHF.In evaluation set, total 820 patients who underwent as first treatment hepatocellular carcinoma included. demographic, laboratory, radiological treatment-related analysed identify was established using identified factors. In validation different cohort 438 included...
// Jeong Goo Kim 1 , Sang Chul Lee Ok-Hee Kee-Hwan Kyo Young Song 2 Kuon Byung Jo Choi Wonjun and Say-June Department of Surgery, Daejeon St. Mary’s Hospital, College Medicine, The Catholic University Korea, Seoul, Republic Korea Seoul Correspondence to: Kim, email: sayjunekim@gmail.com Keywords: 17-DMAG, antioxidant enzymes, HSP90 inhibitor, reactive oxygen species, stomach cancer Received: May 26, 2016     Accepted: March 07, 2017    ...
Mammary serine protease inhibitor (maspin, SERPIN-B5) is expressed in normal human mammary epithelial cells and known to be down-regulated during cancer progression. Aberrant maspin expression has been reported a number of cancers, including pancreatic ovarian cancer. Recently, we identified several genes that may tumor markers for gallbladder (GB) using DNA microarray method. There are no published data regarding GB The aims this study were determine mucosa, adenoma, dysplasia carcinoma GB,...
Purpose This experimental study verified the effect of adipose-tissue-derived stem cells (ASCs) on healing ischemic colonic anastomoses in rats. Methods ASCs were isolated from subcutaneous fat tissue rats and identified as mesenchymal by identification different potentials. An animal model anastomosis was induced modifying Nagahata's method. Sixty male Sprague-Dawley (10-week-old, 370 ± 50 g) divided into two groups (n = 30 each): a control group which sutured single layer with 6-0...
In the present study, we evaluated safety and efficacy of combination therapy with pegylated interferon ribavirin for treating chronic hepatitis C (CHC) patients aged 60 years older.A total 314 CHC patients, who were treated therapy, classified into three groups according to age: (i) younger than 50 (n = 137); (ii) 50-59 109); (iii) or older 68). The sustained virological response (SVR) discontinuation rates compared between groups.Discontinuation due adverse event was more frequent in...
The generally accepted treatment for infected aortic aneurysms involves open surgical resection and debridement, with in situ or extra-anatomical bypass. Occasionally, endovascular management can be substituted the standard operation dependent on patient's condition. We report case of an 81-year-old female a ruptured aneurysm sepsis, successfully treated endovascularly. She had been oral antibiotics one year is doing well 2 years after discharge.
In studies of the molecular basis gastric cancer (GC), microsatellite instability (MSI) is one key factors. Somatic mutations found in GC are expected to contribute MSI-high (H) tumorigenesis. We estimated somatic mutation distribution according MSI status 52 matched pair samples using Ion Torrent S5 XL with AmpliSeq Cancer Hotspot panel. Seventy-five (9.8%) variants consisting 34 hotspot and 41 other likely pathogenic were identified samples. The TP53 was most common (35%, 26/75), followed...
We designed and evaluated the suitability of three customized microsatellite instability (MSI) panels using a combination mono- dinucleotide markers to improve detection MSI status in 56 matched normal gastric cancer specimens.An analysis was performed optimize panel detect two different panels: (1) mononucleotide marker consisting BAT25, BAT26, BAT40, BAT-RII, NR21, NR22, NR24, NR27 (2) containing D2S123, D5S346, D17S250, D17S261, D17S520, D18S34, D18S58. The consisted five, seven, or ten...
Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors. In this study, a targeted next-generation sequencing (NGS) assay with an Oncomine Focus Assay (OFA) panel was used for the genetic characterization of molecular targets 30 Korean patients GIST.Using OFA that enables rapid simultaneous detection hotspots, single...
The aim of the present study was to investigate protective effects ischemic preconditioning for different periods time and elucidate optimal safe renal ischemia-reperfusion (I/R) injury in mice.A total 25 male C57BL/6 mice were randomly divided into 5 groups (sham, I/R, [IP]-3, IP-5, IP-7 groups), which kidney preconditioned with IP various durations then subjected I/R (the last 3 groups). To induce ischemia, left pedicle occluded a nontraumatic microaneurysm clamp 30 minutes followed by...