A5100663848- Sepsis Diagnosis and Treatment
- Respiratory viral infections research
- Pituitary Gland Disorders and Treatments
- Urinary and Genital Oncology Studies
- Pediatric health and respiratory diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Viral gastroenteritis research and epidemiology
- Bacterial Identification and Susceptibility Testing
- Breastfeeding Practices and Influences
- Healthcare and Venom Research
- Cannabis and Cannabinoid Research
- Antibiotics Pharmacokinetics and Efficacy
- Neuroendocrine Tumor Research Advances
- GABA and Rice Research
- Diverse Approaches in Healthcare and Education Studies
- Cardiac Structural Anomalies and Repair
- Lanthanide and Transition Metal Complexes
- Pharmacological Effects and Toxicity Studies
- Leptospirosis research and findings
- Renal cell carcinoma treatment
- Clinical Laboratory Practices and Quality Control
- Nutrition, Health and Food Behavior
- Enhanced Recovery After Surgery
- Xenotransplantation and immune response
- Medical Device Sterilization and Disinfection
Crinetics Pharmaceuticals (United States)
2020-2022
Yonsei University
1980-2021
Severance Hospital
2019-2021
Inje University Busan Paik Hospital
2012-2020
Bumin Hospital Group
2020
Yonsei University Health System
2018
Johannes Gutenberg University Mainz
2017
Genome Research Foundation
2016
Korea Research Institute of Bioscience and Biotechnology
2016
Soonchunhyang University Hospital
2016
Cannabinoids protect neurons from excitotoxic injury. We investigated the mechanisms involved by studying N-methyl-D-aspartate (NMDA) toxicity in cultured murine cerebrocortical vitro and mouse cerebral cortex vivo. The cannabinoid agonist R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)-methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)-methanone mesylate [R(+)-Win 55212] reduced neuronal death cortical cultures treated with 20 microM NMDA, its protective effect was attenuated CB1...
Bcr-Abl-independent signaling pathways are known to be involved in imatinib resistance some patients with chronic myelogenous leukemia (CML). In this study, find new targets for imatinib-resistant CML displaying loss of Bcr-Abl kinase target dependence, we isolated variants, K562/R1, K562/R2, and K562/R3, which showed profound declines levels its tyrosine activity, from K562 cells. Importantly, the mechanism these variants also included aberrant acetylation nonhistone proteins such as p53,...
Abstract: Background: Porcine pancreas is a potential source of material for islet xenotransplantation. However, the difficulty in isolating islets, because their fragility and variability isolation outcome donor age breed, represents major obstacle to porcine In this study, we compared yield specific pathogen‐free (SPF) Chicago Medical School (CMS) miniature pigs with that another pig breed market from local slaughterhouse. Methods: Nine adult CMS (ACM) (>12 months), six young (YCM) (6–7...
The discovery of a novel 4-(4-aminopiperidinyl)-3,6-diarylquinoline series potent SST2 agonists is described. This class molecules exhibit excellent selectivity over SST1, SST3, SST4, and SST5 receptors. compound 3-[4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile (22, paltusotine, formerly known as CRN00808) showed no direct inhibition major cytochrome P450 enzymes or the hERG ion channel had sufficient exposure in rats dogs upon oral dosing. In...
The purpose of this study was to investigate the effects professional nurse's postpartum breast-feeding support on prevalence for mothers who delivered in Baby-Friendly Hospitals (BFH).This quasi experimental designed with a nonequivalent control group post test. subjects were 55 hospitalized delivery room university hospital which selected as BFH Daegu from October 1, 2005 June 30, 2006. Twenty nine assigned and 26 group. Postpartum by nurses' telephone calls provided once week 4 weeks then...
Background : This investigation was to perform the epidemiological surveillance and genetic analysis on respiratory viral agents from children with acute infections in Gwangju. Materials Methods For this study, 3,695 specimens obtained patients were collected by collaboration pediatric hospitals Gwangju between 2005 2007. Specimens screened for 8 viruses including influenza (IFV), human rhinoviruses (HRV), coronaviruses (HCoV), adenoviruses (ADV), parainfluenza (PIV), enteroviruses (HEV),...
To evaluate the ability of fluorescence in situ hybridization (FISH) detecting bladder urothelial carcinoma (BUC), FISH and cytology were compared for evaluation 308 consecutive urine samples from patients suspected having BUC. All underwent cystoscopy identification lesions. The results with assessment. In all, 122 had confirmed Among them, 68 (55.7%) FISH-positive, while only 33 (27%) positive on cytology. According to disease stage (superficial vs. invasive) grade (low high),...
Procalcitonin (PCT) is a useful bacterial infection biomarker with the potential for guiding antibiotic therapy.We evaluated concordance of three automated PCT immunoassays: Kryptor (BRAHMS GmbH, Hennigsdorf, Germany), Atellica IM 1600 (Siemens Healthcare Diagnostics, Munich, and Cobas e801 (Roche Mannheim, Germany).In 119 serum samples concentration < 5.00 μg/L, (reference assay) was compared other two immunoassays by Spearman's rank correlation, regression analysis, at stewardship medical...
Abstract Background Profound knowledge about the physicochemical stability is necessary in order to determine “beyond-use-dates” of ready-to-administer preparations after reconstitution and dilution. This especially true for unstable azanucleoside drugs like decitabine. The aim this study was decitabine dilution Dacogen Methods To frozen reconstituted Diluted Decitabine concentrations were determined at 0, 5, 8, 12, 24 48 hours preparation. pH-values hours. Each sample assayed by a validated...
BACKGROUNDThe aim of this study was to confirm the usefulness cervicovaginal smears in screening squamous cell neoplasms uterine cervix by comparative analysis between cytologic diagnosis and histologic tissue specimens.METHODSWe selected 743 patients who had both evaluations colposcopic biopsy, conization, or hysterectomy at Kangbuk Samsung Medical Center January 2005 December 2007.RESULTSThe accuracy rate diagnoses 93.0% (691/743) showed a high correspondence (kappa value, 0.770, p-value,...
Background and Objectives:Antibiotic prophylaxis of infective endocarditis is required before high-risk procedures in patient with heart diseases. Although guidelines for the prevention were proposed by American Heart Association 1997, compliance to these recommendations has not been evaluated Korea. Subjects Methods:This was a retrospective, multicentered study 8 Korean university hospitals. Patients diseases, having undergone invasive dental between Jan. 1, 2000 Dec. 31, 2003, enrolled....
BACKGROUNDThe aim of this study was to evaluate differences in cytologic findings between conventional preparation (CP) and SurePath(TM) liquid-based (LBP) thyroid fine needle aspiration (FNA).METHODSWe analyzed cytological features on a total 182 FNAs (83 CP 99 LBP) that were histologically confirmed as nodular hyperplasia (NH) or papillary carcinoma (PAC).RESULTSLBP superior cellular preservation cellularity than CP. Interestingly, LBP, NH similarly high compared PAC. The three-dimensional...
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important nosocomial pathogens worldwide. This study was performed to investigate characterization MRSA isolated from healthy persons in Gwangju area. A total 404 nasal swab samples collected during October 2011 and May 2012 Gwangu, Korea. survey on conducted with meat distributors (n=230), pre-school children (n=108), officers (n=66), respectively. To confirm MRSA, polymerase chain reaction (PCR) for S. specific gene mecA...
The myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis associated with multilineage cytopenias leading to serious morbidity or mortality, and the additional risk of leukemic transformation. management patients MDS can be very complex varies according both clinical manifestations in individual as well presence complicating medical conditions. However, therapeutic dilemmas still exist for due multifactorial pathogenetic features disease, its heterogeneous stages,...
The recent mumps epidemic in South Korea has generated a large amount of public concern. This study attempted to analyze molecular epidemiological changes virus circulating Gwangju metropolitan area, Korea. 953 throat swab samples were collected from patients with parotitis May 2013 July 2014. majority (71.5%) these cases have occurred middle or high school students aged 15 19 years. All tested using reverse transcription polymerase chain reaction (RT-PCR) that targets the short hydrophobic...
Results: The correlation between capillary and venous samples for total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDLC), low (LDLC) were 0.615, 0.605, 0.517, 0.533, respectively, showing statistical significance (all P<0.05). All except TG had lower mean values than percent bias TC (-13.25%), (21.54%), HDLC (-29.61%), LDLC (-22.93%) all outside of the acceptable ranges, misclassification rates generally higher CVD risk categories within lipid parameters HDLC. Conclusion:...