A5019488474- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Sepsis Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Clinical Laboratory Practices and Quality Control
- Lipoproteins and Cardiovascular Health
- Advanced Mathematical Physics Problems
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Iron Metabolism and Disorders
- Urinary Tract Infections Management
- Chronic Myeloid Leukemia Treatments
- Navier-Stokes equation solutions
- Bacterial Identification and Susceptibility Testing
- Respiratory viral infections research
- Cancer-related Molecular Pathways
- Metabolomics and Mass Spectrometry Studies
- Parvovirus B19 Infection Studies
- Hepatitis Viruses Studies and Epidemiology
- Cancer Research and Treatments
- Influenza Virus Research Studies
- Meta-analysis and systematic reviews
- Advanced Harmonic Analysis Research
- Hypothalamic control of reproductive hormones
Hallym University Sacred Heart Hospital
2020-2023
Yonsei University
2003-2022
Severance Hospital
2012-2022
Hanyang University
2022
Anyang University
2022
Korea Institute of Brain Science
2015
Abstract Although tuberculosis (TB) is a severe health problem worldwide, the current diagnostic methods are far from optimal. Metabolomics increasingly being used in study of infectious diseases. We performed metabolome profiling to identify potential biomarkers patients with active TB. Serum samples 21 pulmonary TB, 20 subjects latent TB infection (LTBI), and 28 healthy controls were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) followed by multivariate...
Thalassemia is the most common form of hereditary anemia. Here, we aimed to investigate 13-year trend epidemiologic profiles and risk comorbidities in thalassemia using a nationwide population-based registry Korea. Diagnosis thalassemia, transfusion events patients with were identified Korean National Health Insurance database, which includes entire population. The prevalence increased from 0.74/100,000 2006 2.76/100,000 2018. Notably, incidence rate has nearly doubled last 2 years...
We aimed to determine the major contributing component of metabolic syndrome (MetS) that results in an elevated small dense LDL cholesterol (sdLDL-C) concentration and sdLDL-C/LDL-C ratio.Four hundred forty-seven subjects (225 men; 222 women) with MetS were randomly selected from Korean Metabolic Syndrome Research Initiatives-Seoul cohort study. Age- sex-matched healthy controls (181 179 also same cohort.A comparison median values sdLDL-C between subgroups, divided according whether met or...
Abstract Background Bile acids (BAs) have been demonstrated to exert a variety of metabolic effects and alterations in BAs reported patients with obesity, insulin resistance (IR) type 2 diabetes mellitus (T2DM). However, it is unclear which condition the main contributor BAs. In this study, we investigate associations between different BA profiles glycemia, obesity or IR status. Methods Fasting serum concentrations 15 species were determined total 241 individuals (71 drug-naïve T2DM, 95...
Transplant recipients are vulnerable to life-threatening community-acquired respiratory viruses (CA-RVs) infection (CA-RVI). Even if non-transplant critically ill patients in intensive care unit (ICU) have serious CA-RVI, comparison between these groups remains unclear. We aimed evaluate clinical characteristics and mortality of CA-RVI except seasonal influenza A/B transplant ICU. collected 37,777 CA-RVs multiplex real-time reverse transcription-polymerase chain reaction test results...
We evaluated quantitative hepatitis B surface antigen (qHBsAg) assays and a virus (HBV) core-related (HBcrAg) assay. A total of 529 serum samples from patients with were tested. HBsAg levels determined by using the Elecsys (Roche Diagnostics, Indianapolis, IN) Architect (Abbott Laboratories, Abbott Park, IL) qHBsAg assays. HBcrAg was measured Lumipulse assay (Fujirebio, Tokyo, Japan). Serum aminotransferases HBV DNA respectively quantified Hitachi 7600 analyzer (Hitachi High-Technologies,...
A novel multiplex real-time PCR assay for concurrent detection of hepatitis viruses was evaluated its clinical performance in screening patients with acute hepatitis. total 648 serum samples were collected from symptoms Concurrent nucleic acids HAV, HBV and HCV performed using the Magicplex™ HepaTrio Real-time Detection test. Serum acid levels also quantified by Cobas® AmpliPrep/Cobas® TaqMan® (CAP/CTM) tests. Patients' medical records reviewed. Concordance rates between results CAP/CTM...
Li-Fraumeni syndrome (LFS) is a rare, inherited associated with increased risk of various early-onset tumors. Since the introduction classic LFS criteria, criteria have been proposed to include patients incomplete features, which make up Li-Fraumeni-like syndromes (LFL). Germline missense mutations TP53 are primary cause and LFL. Mutations mostly reside in DNA-binding domain gene dominant-negative effect (DNE) over alternate wild-type alleles. mutation c.566C>T results GCC (Ala) GTC (Val) at...
We aimed to suggest muscle mass-based criteria for using of the cystatin C test accurate estimated glomerular filtration rate (eGFR).We recruited 138 Korean subjects and evaluated eGFRcr (derived from Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) based on creatinine) was compared eGFRcys as reference value. The skeletal mass index (SMI) by bioelectrical impedance analysis (BIA) used representative mass. Calf circumference (CC) also evaluated. defined patients those with values...
The coronavirus disease (COVID-19) outbreak affected the utilization and management of blood products in hospitals. Blood shortages occurred owing to social distancing policies reduction donors. However, only a few studies examined whether these changes usage transfusion patterns. We retrospectively reviewed component according hospital departments phases surgery transfused patients admitted between 1 March 2019 28 February 2021, single center Anyang, Korea. also analyzed length stay...
서론 지질(脂質)검사는 이상지혈증의 진단, 심혈관질환의 위험도 예측 및 치료효과 추적에 사용되는 중요한 검사이다.심혈관질 환은 전 세계적으로 사망을 유발하는 원인들 중 하나이 며, 정확한 검사실 검사결과는 진단 치료방침 결정에 필수적이다[1].미국에서 연구된 자료에 따르면, 미국 질병관리본부에서 진행한 지질검사 표준화 사업을 통해 매년 최소 3억3천8백만 달러에 해당하는 경제적 효과(총 콜레스테 롤 검사 표준화로 인한 총 콜레스테롤 관리 개선 기여도를 최 소 0
Procalcitonin (PCT) is a useful bacterial infection biomarker with the potential for guiding antibiotic therapy.We evaluated concordance of three automated PCT immunoassays: Kryptor (BRAHMS GmbH, Hennigsdorf, Germany), Atellica IM 1600 (Siemens Healthcare Diagnostics, Munich, and Cobas e801 (Roche Mannheim, Germany).In 119 serum samples concentration < 5.00 μg/L, (reference assay) was compared other two immunoassays by Spearman's rank correlation, regression analysis, at stewardship medical...
The adoptive transfer of ex vivo-expanded natural killer (NK) cells has recently been employed as an alternative cancer treatment in certain institutions. However, the safety profiles this strategy remain uncharacterized. We evaluated three patients who exhibited elevated serum parathyroid hormone (PTH) levels without relevant clinical manifestations and had a history autologous NK cell therapy. PTH concentration was measured using second-generation assay, thyroglobulin assay. Subsequently,...
The Alinity i system (Abbott), a recently developed automated immunoassay analyzer, has compact footprint and throughput of 200 tests per hour. Here, we present the first performance evaluation thyroid function test (TFT) on system.We performed precision, linearity, comparison, functional sensitivity, carryover, reference interval verification 4 hormones (Thyroid Stimulation Hormone; TSH, total T3, free T4, T4) using reagents provided by manufacturer following guidelines Clinical Laboratory...
Appropriate reference intervals of serum insulin-like growth factor I (IGF-I) is important for diagnosing and monitoring patients with hormone-related diseases. To establish intervals, adult individuals (<i>n</i>=1,334, 680 men 654 women) were divided into six age groups (20–29, 30–39, 40–49, 50–59, 60–69, ≥70). Serum IGF-I was measured by chemiluminescence immunoassay (Liaison). Concordance patient classification based on manufacturer’s standard deviation score (SDS) evaluated....