A5043173224- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Thyroid Cancer Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Artificial Intelligence in Healthcare and Education
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Adrenal Hormones and Disorders
- Bone health and treatments
- Bone health and osteoporosis research
- Immune cells in cancer
- Diet and metabolism studies
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Radiology practices and education
- Reproductive Biology and Fertility
- Biochemical Analysis and Sensing Techniques
- Genetic Syndromes and Imprinting
Yonsei University
2014-2025
Gangnam Severance Hospital
2023-2024
University of Freiburg
2024
Korea Institute of Radiological and Medical Sciences
2024
Severance Hospital
2016-2023
Korea University
2022
Anyang University
2021
Hanyang University
2021
Jobs With Justice
2016
Chulalongkorn University
2014
Purpose:The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial.We aimed to evaluate the relationship serum 25-hydroxy-vitamin D3 [25(OH)D3] anti-thyroid antibody levels.Materials Methods: 25(OH)D3, antibodies, function measured in 304 patients who visited endocrinology clinic were analyzed.The subgrouped into AITDs or non-AITDs category according presence absence of antibodies.The peroxidase (TPOAb) 25(OH)D3 was evaluated.Results: The with...
In the myeloid compartment of tumor microenvironment, CD244 signaling has been implicated in immunosuppressive phenotype monocytes. However, precise molecular mechanism and contribution to immunity monocytes/macrophages remains elusive due co-existing lymphoid cells expressing CD244.
Bone loss is considered to begin with menopause in women and later life men; however, several recent studies have reported that bone began young adults. There are still discordant results concerning age-related changes mineral density (BMD), especially nonvertebral bone. The objective of the study was investigate BMD Korean youth. This a population-based, cross-sectional from Fourth Korea National Health Nutrition Examination Surveys. A total 10,575 (4,731 males 5,844 females) aged 10–80 yr...
Recent functional genomic studies revealed that the oncogenic activity of focally amplified lncRNA on chromosome 1 (FAL1, ENSG00000228126) contributes to tumor growth by p21 repression in human cancers. However, expression FAL1 was not investigated papillary thyroid cancer (PTC). We aimed determine if up-regulated PTC compared paired contralateral normal tissues, and investigate potential targets this its clinicopathological significance PTC. analyzed levels 100 samples matched tissue...
Significance Glucocorticoids are well known to play a major role in obesity, but underlying mechanisms have been obscure. We demonstrate that the small G protein Dexras1, first identified based on its dramatic induction by glucocorticoids, mediates adipogenic differentiation of preadipocytes, as diet-induced obesity intact rodents. Thus, adipogenesis preadipocytes is abolished Dexras1 deletion and selectively induced expression. Relevance animals evident from our experiments wherein...
Although glycated haemoglobin (A1c) levels are similar among patients with type 2 diabetes, the albumin (GA)/A1c ratio varies considerably. On basis of hypothesis that endogenous insulin secretion might be correlated GA/A1c ratio, we investigated whether secretory function or resistance has different effects on in diabetes using standardized liquid meal test.A clinical, retrospective study.A total 758 ingested a (i.e. 500 kcal, 17·5 g fat, 68·5 carbohydrate and protein). The subjects were...
Thyrogen, a recombinant human thyroid-stimulating hormone (rhTSH), has short half-life in the bloodstream, which necessitates multiple doses during treatment. Therefore, we developed new long-acting rhTSH using anti-serum albumin Fab-associated (SAFA) technology to validate its biological activity through vitro assays, pharmacokinetic (PK) studies healthy mice, and pharmacodynamics (PD) TSH-suppressed mouse model.SAFA-TSH was produced Chinese hamster ovary expression system. To verify...
Medullary thyroid cancer originates from parafollicular C-cells in the thyroid. Despite successful thyroidectomy, localizing remnant cells patients with elevated calcitonin and carcinoembryonic antigen levels remains a challenge. Extranasal odorant receptors are expressed non-olfactory tissues, including C-cells. This study evaluates receptor signals C-cells, specifically, presence of olfactory marker protein, further assesses ability protein treating medullary cancer. We used...
Several cancers show increased levels of lactate dehydrogenase A (LDHA), which are associated with cancer progression. However, it remains unclear whether LDHA papillary thyroid (PTC) aggressiveness or the presence PTC prognostic marker, BRAFV600E mutation. This study aimed to evaluate potential as a marker. expression was examined in 83 tissue specimens by immunohistochemistry. Human cell lines were genetically manipulated overexpress treated BRAF-specific short hairpin RNA (shBRAF), whose...
Telomerase reverse transcriptase (TERT) promoter mutation has been investigated for its clinical and prognostic significance in aggressive papillary thyroid cancer (PTC). In this study, we aimed to assess the prevalence, clinicopathologic features, treatment outcomes of TERT mutation-positive PTCs along with common BRAF V600E mutation. We performed mutational analyses patients who had undergone surgery at our institution since 2019. reviewed analyzed 7797 PTC study. The prevalence mutations...
Thyroid-stimulating hormone (TSH)-secreting pituitary adenoma (TSHoma) is a rare type of adenoma; thus, little known about TSHomas. The purpose this study was to analyze clinical characteristics and therapeutic outcomes TSHomas based on single-center experience. authors also searched for reliable preoperative early postoperative factors that could predict long-term endocrinological remission.
Nonthyroidal illness (NTI), often observed in critically ill patients, arises through diverse alterations the hypothalamus-pituitary-thyroid (HPT) axis. However, causal relationship between underlying disease and NTI diversity patients is poorly understood.The aim of this study was to examine severity adverse outcomes with respect their disease(s).The medical records 616 admitted intensive care unit (ICU) January 2009 October 2014 were retrospectively reviewed. Patients known diseases or...
Introduction Administration of follicle-stimulating hormone (FSH) has been recommended to stimulate spermatogenesis in infertile men with hypogonadotropic hypogonadism, whose sperm counts do not respond human chorionic gonadotropin alone. However, FSH a short serum half-life requiring frequent administration maintain its therapeutic efficacy. To improve pharmacokinetic properties, we developed unique albumin-binder technology, termed “anti-serum albumin Fab-associated” (SAFA) technology. We...
Ectopic Cushing's syndrome due to various malignancies is not uncommon. However, a few cases of ectopic caused by corticotropin-releasing hormone (CRH), or CRH with adrenocorticotropic (ACTH) have been reported. A 28-year-old woman presented acute upper gastrointestinal bleeding an active ulcer, located atypically in the 2nd portion duodenum. Further work-up revealed high gastrin levels and abdominal computed tomography (CT) scans showed large pancreatic head mass multiple liver metastases....