A5047836971- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Enterobacteriaceae and Cronobacter Research
- Urinary Tract Infections Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial biofilms and quorum sensing
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Vibrio bacteria research studies
- Tuberculosis Research and Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Pneumonia and Respiratory Infections
- Infections and bacterial resistance
- Streptococcal Infections and Treatments
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Nephrotoxicity and Medicinal Plants
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bacterial Infections and Vaccines
- Infective Endocarditis Diagnosis and Management
- Bacterial Genetics and Biotechnology
- Microscopic Colitis
Yonsei University
2016-2025
Gangnam Severance Hospital
2015-2025
University of Nevada, Reno
2025
Severance Hospital
2013-2024
Maria Fertility Hospital
2024
Armed Forces Capital Hospital
2020
Chonnam National University
2019
Inje University Busan Paik Hospital
2019
National Health Insurance Service Ilsan Hospital
2018
Pfizer (United States)
2018
To investigate the prevalence of plasmid-mediated fosfomycin resistance determinants among extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae their genetic environments. A total 347 non-duplicate ESBL-producing E. (165) K. (182) were collected. The MICs determined by agar dilution method according to CLSI guidelines. PCR was used detect plasmid-encoded genes (fosA, fosA3, fosB fosC2). For isolates harbouring genes, sequence types (STs) determined....
Some of the previously reported clinical isolates Elizabethkingia meningoseptica may be later named species We determined accuracy identification (with two matrix-assisted laser desorption ionization-time flight mass spectrometry [MALDI-TOF MS] systems and Vitek 2 GN card), relative prevalence three spp. in specimens, antimicrobial susceptibility identified by 16S rRNA gene sequencing. Specimens for culture were collected from patients a university hospital Seoul, South Korea, between 2009...
National surveillance of antimicrobial resistance becomes more important for the control and determination treatment guidelines. We analyzed Korean Antimicrobial Resistance Monitoring System (KARMS) data collected from 2013 to 2015.Of KARMS participants, 16 secondary or tertiary hospitals consecutively reported rates 2015. Data duplicate isolates institutions with fewer than 20 were excluded. To determine long-term trends, previous 2004 2012 also considered.The prevalence...
To monitor national antimicrobial resistance (AMR), the Korea Global AMR Surveillance System (Kor-GLASS) was established. This study analyzed bloodstream infection (BSI) cases from Kor-GLASS phase I January 2017 to December 2019. Nine non-duplicated target pathogens, including Staphylococcus aureus, Enterococcus faecalis, faecium, Streptococcus pneumoniae, Escherichia coli, Klebsiella Pseudomonas aeruginosa, Acinetobacter spp., and Salmonella were isolated blood specimens eight sentinel...
We investigated an outbreak of Acinetobacter baumannii in intensive care unit and the surgery, medicine, neurology, urology wards Kosin University Gospel Hospital Busan, Korea. The involved 36 cases infection by A. producing OXA-23 beta-lactamase over 8-month period was caused a single pulsed-field gel electrophoresis clone. epidemic isolates were characterized modified cloverleaf synergy test. Isoelectric focusing crude bacterial extracts detected one nitrocefin-positive band with pI value...
Objectives: To assess the prevalence and genotypes of Ambler class A extended-spectrum β-lactamases (ESBLs) in Korea.
Ultraviolet (UV)B irradiation induces the production of matrix metalloproteinases (MMPs) by activating cellular signaling transduction pathways, which are responsible for degradation or synthesis inhibition collagenous extracellular in connective tissues, causing skin photoaging. Using human fibroblast (HS68) cell line present study, we investigated inhibitory effects fucoidan on MMP-1 expression various vitro experiments and elucidated pathways inhibition. Pretreatment with inhibited...
To examine mutations within the penA, mtrR, porB, ponA and pilQ genes of Neisseria gonorrhoeae to determine their contribution cephalosporin resistance. A total 46 N. isolates with reduced susceptibility cefixime or ceftriaxone (MICs ≥ 0.12 mg/L) two susceptible were selected. The full sequence penA partial sequences previously reported as hot mutation sites other analysed. Genotyping by multiantigen typing (NG-MAST) was also performed. mosaic penicillin-binding protein 2 (PBP 2) found in a...
Purpose:The increasing prevalence of antimicrobial resistant bacteria has become a serious worldwide problem.The aim this study was to analyze resistance data generated in 2009 by hospitals and commercial laboratories participating the Korean Nationwide Surveillance Antimicrobial Resistance program.Materials Methods: Susceptibility were collected from 24 two laboratories.In analysis, did not include intermediate susceptibility.Duplicate isolates excluded analysis hospital isolates, but...
The purpose of this study was to investigate the molecular epidemiology CTX-M-14-producing Escherichia coli clinical isolates from Korea. A total 138 non-duplicate E. showing reduced susceptibility or resistance ceftazidime and/or cefotaxime were included in study. Resistance genes, genetic environment, R plasmid size and replicon type, sequence type (ST) XbaI-macrorestriction patterns determined. Among isolates, 35 found carry blaCTX-M-14 gene. ISEcp1 element identified upstream region gene...
The Korean government established an antimicrobial resistance (AMR) surveillance system, compatible with the Global AMR Surveillance System (GLASS): Kor-GLASS. We describe results from first year of operation Kor-GLASS May 2016 to April 2017, comprising all non-duplicated clinical isolates major pathogens blood, urine, faeces and urethral cervical swabs six sentinel hospitals. Antimicrobial susceptibility tests were carried out by disk diffusion, Etest, broth microdilution agar dilution...
A total of 431 Pseudomonas aeruginosa clinical isolates were collected from 29 general hospitals in South Korea 2015. Antimicrobial susceptibility was tested by the disk diffusion method, and MICs carbapenems determined agar dilution method. Carbapenemase genes amplified PCR sequenced, structures class 1 integrons surrounding carbapenemase gene cassettes analyzed mapping. Multilocus sequence typing (MLST) pulsed-field gel electrophoresis (PFGE) performed for strain typing. Whole-genome...
To investigate the risk factors of patients with Klebsiella pneumoniae (KP) bloodstream infection (BSI) a focus on antimicrobial resistance and virulence factors. All KP BSI (n = 579) from six general hospitals during 1 year period were included in this study. The hosts causative isolates assessed to determine associations 30 day mortality by multivariate Cox hazards modelling. rate was 16.9% (98/579). Among host-associated factors, increased SOFA score leucopenia status exhibited strong...
Extended-spectrum cephalosporin (ESC)-resistant Enterobacteriaceae is an increasingly important problem in both human and veterinary medicine. The aims of this study were to describe a comparative molecular characterization carrying ESC resistance genes, encoding extended-spectrum β-lactamase (ESBL) AmpC, isolated from stool samples, rectal swabs companion animals, the environment veterinarian hospitals South Korea, examine their possible dissemination transmission. genes identified by PCR...
Abstract Improving predictive models for intensive care unit (ICU) inpatients requires a new strategy that periodically includes the latest clinical data and can be updated to reflect local characteristics. We extracted from all adult patients admitted ICUs of two university hospitals with different characteristics 2006 2020, total 85,146 were included in this study. Machine learning algorithms trained predict in-hospital mortality. The performance conventional scoring machine was assessed...
Here, we aimed to elucidate the differences in microbiota composition between patients with gout and those asymptomatic hyperuricemia (asHU) determine effect of uric acid-lowering therapy (ULT) on gut microbiome.Stool samples from asHU (n=8) three groups patients, i.e., acute before ULT (0ULT, n=14), same after 30-day (30ULT, n=9), chronic ≥6-month (cULT, n=18) were collected analyzed using 16S rRNA gene-based pyrosequencing. The microbial taxonomy communities, species diversity,...
ABSTRACT To determine the prevalence and genotypes of extended-spectrum beta-lactamases (ESBLs) among clinical isolates Klebsiella pneumoniae Escherichia coli , we performed antibiotic susceptibility testing, pI determination, induction transconjugation, DNA sequencing analysis. Among 509 collected from 13 university hospitals in Korea, 39.2% produced ESBLs. ESBL-producing were detected every region Korea. A total 44.6% both TEM- SHV-type ESBLs, 52% transferred resistance to ceftazidime by...
Summary The emergence and dissemination of extended‐spectrum (ES) β‐lactamases induce therapeutic failure a lack eradication clinical isolates even by third‐generation β‐lactam antibiotics like ceftazidime. CMY‐10 is plasmid‐encoded class C β‐lactamase with wide spectrum substrates. Unlike the well‐studied ES from Enterobacter cloacae GC1, Ω‐loop does not affect active site conformation catalytic activity CMY‐10. Instead, three‐amino‐acid deletion in R2‐loop appears to be responsible for...
This study was performed to assess the prevalence and genotypes of plasmid-borne extended-spectrum beta-lactamases (ESBLs) AmpC in Escherichia coli Korea. A total 576 isolates E. collected from 12 Korean hospitals during May July 2007. phenotypic confirmatory test detected ESBLs 82 (14.2 %) isolates. The most common types identified were CTX-M-14 (n=32) CTX-M-15 (n=27). diversity CTX-M mutants, including CTX-M-15, CTX-M-27 CTX-M-57, with significant hydrolytic activity against ceftazidime...