A5088760781- Marine Sponges and Natural Products
- Echinoderm biology and ecology
- Seaweed-derived Bioactive Compounds
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Activity
- Synthetic Organic Chemistry Methods
- Bioactive Compounds and Antitumor Agents
- Marine Biology and Environmental Chemistry
- Natural product bioactivities and synthesis
- Sphingolipid Metabolism and Signaling
- Chemical synthesis and alkaloids
- Molecular spectroscopy and chirality
- Steroid Chemistry and Biochemistry
- Traditional and Medicinal Uses of Annonaceae
- Carbohydrate Chemistry and Synthesis
- Marine and coastal plant biology
- Marine Toxins and Detection Methods
- Sesquiterpenes and Asteraceae Studies
- Nicotinic Acetylcholine Receptors Study
- Phytochemistry and Bioactive Compounds
- Chemical Synthesis and Analysis
- Algal biology and biofuel production
- Aquaculture Nutrition and Growth
- Synthesis of heterocyclic compounds
- Aquatic life and conservation
Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences
2016-2025
Far Eastern Branch of the Russian Academy of Sciences
2007-2022
Far Eastern Federal University
2012-2021
Russian Academy of Sciences
2004-2015
Institute of Bioorganic Chemistry
1999-2012
Dong-A University
2012
Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences
1973-2012
Zoological Institute
2005-2008
V. B. Sochava Institute of Geography
2008
Development Agency of Serbia
2008
Many marine-derived polysaccharides and their analogues have been reported as showing anticancer cancer preventive properties. These compounds demonstrate interesting activities special modes of action, differing from each other in both structure toxicity profile. Herein, literature data concerning marine are reviewed. The structural diversity, the biological activities, molecular mechanisms action discussed.
Ultraviolet (UV)B irradiation induces the production of matrix metalloproteinases (MMPs) by activating cellular signaling transduction pathways, which are responsible for degradation or synthesis inhibition collagenous extracellular in connective tissues, causing skin photoaging. Using human fibroblast (HS68) cell line present study, we investigated inhibitory effects fucoidan on MMP-1 expression various vitro experiments and elucidated pathways inhibition. Pretreatment with inhibited...
Monanchocidin (1), a guanidine alkaloid with an unprecedented skeleton system derived from polyketide precursor, (ω-3)-hydroxy fatty acid, and containing 2-aminoethyl- 3-aminopropyl-substituted morpholine hemiketal ring, has been isolated the sponge Monanhora pulchra. The structure of 1 was assigned on basis detailed analysis 1D 2D NMR spectra, mass spectrometry, results chemical transformations. Compound shows pro-apoptotic cytoxic activities.
Echinochrome A (Ech A) is a naphthoquinoid pigment from sea urchins that possesses antioxidant, antimicrobial, anti-inflammatory and chelating abilities. Although Ech the active substance in ophthalmic cardiac drug Histochrome®, its underlying cardioprotective mechanisms are not well understood. In this study, we investigated protective role of against toxic agents induce death rat myoblast H9c2 cells isolated cardiomyocytes. We found cardiotoxic tert-Butyl hydroperoxide (tBHP, organic...
Monanchocidin A (MonA) is a novel alkaloid recently isolated from the marine sponge Monanchora pulchra. The compound reveals cytotoxic activity in genitourinary cancers including cisplatin-sensitive and -resistant germ cell tumor (GCT) lines, hormone-sensitive castration-resistant prostate carcinoma lines different bladder lines. In contrast, non-malignant cells were significantly less sensitive. MonA highly synergistic with cisplatin GCT cells. Induction of autophagy at lower lysosomal...
Despite recent advances in the treatment of metastatic castration-resistant prostate cancer (CRPC), outcome patients remains poor due to development drug resistance. Thus, new drugs are urgently needed. We investigated efficacy, toxicity and mechanism action marine triterpene glycoside frondoside A (FrA) using CRPC cell lines vitro vivo. FrA revealed high efficacy human cells, while non-malignant cells were less sensitive. Remarkably, proliferation colony formation resistant enzalutamide...
Structures, taxonomic distribution and biological activities of polar steroids isolated from various marine organisms over the last 8—10 years are considered. The peculiarities steroid biogenesis in biota their possible functions discussed. Syntheses some highly active described. bibliography includes 254 references.
UVB reduces type I procollagen levels and increases matrix metalloproteinases-1 (MMP-1) in human skin plays a major role the process of photoaging. We previously reported that fucoidan inhibits UVB-induced MMP-1 expression at protein mRNA fibroblasts (HS68). Yet, effects on promoter activity have not been investigated. In this study, we assessed inhibition increase synthesis fibroblasts. Fucoidan treatment significantly inhibited compared to irradiation alone. also increased dose-dependent...
New unusual polycyclic guanidine alkaloids monanchocidins B-E (2-5) along with monanchocidin A (1), which we recently described, were isolated from the Far-Eastern marine sponge Monanchora pulchra. Their structures established using spectroscopic data and chemical transformations. Compounds 1-5 show potent cytotoxic activities against HL-60 human leukemia cells IC50 values of 540, 200, 110, 830, 650 nM, respectively.
Echinochrome A (Ech A) is a natural pigment from sea urchins that has been reported to have antioxidant properties and cardio protective effect against ischemia reperfusion injury. In this study, we ascertained whether Ech enhances the mitochondrial biogenesis oxidative phosphorylation in rat myoblast H9c2 cells. To study effects of on biogenesis, measured mass, level phosphorylation, regulatory gene expression. treatment did not induce cytotoxicity. However, enhanced oxygen consumption rate...
A fucosylated chondroitin sulfate (FCS) was isolated from the body wall of Pacific sea cucumber Cucumaria japonica by extraction in presence papain followed Cetavlon precipitation and anion-exchange chromatography. FCS shown to contain d-GalNAc, d-GlcA, l-Fuc molar proportions about 1:1:1:4.5. Structure elucidated using NMR spectroscopy methylation analysis native polysaccharide products its desulfation carboxyl reduction. The a typical core →3)-β-d-GalNAc-(1→4)-β-d-GlcA-(1→. Sulfate groups...
Advanced urothelial carcinomas represent a considerable clinical challenge as they are difficult to treat. Platinum-based combination regimens obtain response rates ranging from 40 70% in first-line therapy of advanced carcinoma. In the majority cases, however, duration these responses is limited, and when progression occurs, outcome generally poor. Therefore, novel therapeutic strategies urgently needed. The purpose current research investigate anticancer effects mode action marine...
Guanidine alkaloids from sponges Monanchora spp. represent diverse bioactive compounds, however, the mechanisms underlying bioactivity are very poorly understood. Here, we report results of studies on cytotoxic action, ability to inhibit EGF-induced neoplastic transformation, and effects MAPK/AP-1 signaling eight rare guanidine alkaloids, recently isolated marine sponge pulchra, namely: monanchocidin A (1), B (2), monanchomycalin C (3), ptilomycalin (4), (5), normonanchocidin D (6),...
Doxorubicin, an anthracycline from Streptomyces peucetius, exhibits antitumor activity against various cancers. However, doxorubicin is cardiotoxic at cumulative doses, causing increases in intracellular reactive oxygen species the heart. Spinochrome D (SpD) has a structure of 2,3,5,6,8-pentahydroxy-1,4-naphthoquinone and structural analogue well-known sea urchin pigment echinochrome A. We previously reported that A cardioprotective toxicity. In present study, we assessed effects SpD...
Abnormal sulfide catabolism, especially the accumulation of hydrogen (H2S) during hypoxic or inflammatory stresses, is a major cause redox imbalance-associated cardiac dysfunction. Polyhydroxynaphtoquinone echinochrome A (Ech-A), natural pigment marine origin found in shells and needles many species sea urchins, potent antioxidant inhibits acute myocardial ferroptosis after ischemia/reperfusion, but chronic effect Ech-A on heart failure unknown. Reactive sulfur (RSS), which include catenated...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVaracin and Three New Marine Antimicrobial Polysulfides from the Far-Eastern Ascidian Polycitorsp.Tatyana N. Makarieva, Valentin A. Stonik, Andrei S. Dmitrenok, Boris B. Grebnev, Vladimir V. Isakov, Nikolai M. Rebachyk, Yakov W. RashkesCite this: J. Nat. Prod. 1995, 58, 2, 254–258Publication Date (Print):February 1, 1995Publication History Published online1 July 2004Published inissue 1 February...