A5024622145- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Transplantation: Methods and Outcomes
- Food Quality and Safety Studies
- Neurological Complications and Syndromes
- Pharmacological Effects and Toxicity Studies
- Pancreatic function and diabetes
- Organ and Tissue Transplantation Research
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Hepatitis C virus research
- Dialysis and Renal Disease Management
- Pregnancy and Medication Impact
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Adenosine and Purinergic Signaling
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Ecology and Conservation Studies
- Biochemical and Molecular Research
- Chronic Kidney Disease and Diabetes
Shriners Hospitals for Children - St. Louis
2025
Yonsei University
2015-2024
Severance Hospital
2013-2023
Yonsei University Health System
2012-2021
Weatherford College
2021
University Health System
2017-2021
Seoul National University
2019
Asan Medical Center
2013-2016
University of Ulsan
2004-2016
Ulsan College
2013-2016
Increased oxidative stress and mitochondrial dysfunction in obese adipocytes contribute to adipokine dysregulation, inflammation, insulin resistance.Through an advanced proteomic analysis, we found that peroxiredoxin 3 (Prx3), a thioredoxin-dependent peroxidase, is highly expressed 3T3-L1 compared preadipocytes. Interestingly, db/db mice human subjects, adipose Prx3 levels were significantly decreased, indicating its association with obesity. We therefore employed knockout (KO) transfected...
In Brief Background Strategies allowing calcineurin inhibitor minimization while maintaining efficacy may improve renal transplant outcomes. Methods A2309 was a 24-month, phase IIIb, open-label trial of 833 de novo recipients randomized to everolimus, targeting trough concentrations 3–8 or 6–12 ng/mL plus reduced-exposure cyclosporine A (CsA) mycophenolic acid (MPA) 1.44 g per day standard-exposure CsA. All patients received basiliximab±corticosteroids. The incidence the primary composite...
The donor organ shortage has been one of the major barriers to kidney transplantation in Korea, even though there a small but steady flow cadaveric donations for last decade. To expand pool transplantation, we have developed exchange program at our institution and Korea. was first started end-stage renal disease patients who had willing incompatible related donors due positive lymphocyte cross-match. transplantations were performed using exchanged kidneys between two families with successful...
OBJECTIVE To investigate the relationship of caveolin‐1 expression and microvessel density (MVD), a reflection angiogenesis, with metastasis prognosis in patients clear cell renal carcinoma (RCC). PATIENTS AND METHODS Formalin‐fixed, paraffin‐embedded tissue sections RCC from 67 who had undergone radical nephrectomy were stained immunohistochemically specific antibodies against CD34. Caveolin‐1 immunostaining was semi‐quantitatively estimated based on proportion (percentage positive cells)...
Although the mechanism of susceptibility to chronic persistent hepatitis B virus (HBV) infection is not well clarified, immunogenetic factors host may have a role. Recently, strong association between HLA-DR13 and self-limited course HBV has been reported. To determine whether elimination related particular HLA allele, we studied markers HLA-DR phenotypes 1,272 Koreans who had visited Yonsei University Medical Center for renal transplantation. They included 330 transplant donors. Subjects...
In 2009, the Oxford classification was developed as a pathological system for immunoglobulin A nephropathy (IgAN) to predict risk of disease progression. The aim this retrospective study evaluate clinical and pathologic relevance in Korean patients with diagnosis IgAN. We reviewed renal pathology archives from January 2000 December 2006 at Seoul St Mary's Hospital Korea identified 273 patients, who were diagnosed having enrolled 197 available further clinicopathologic analysis. All cases...
OBJECTIVE—The aim of this study was to assess the incidence posttransplantation diabetes mellitus (PTDM) in renal allograft recipients and investigate factors contributing onset progression PTDM its underlying pathogenic mechanism(s). RESEARCH DESIGN AND METHODS—A total 77 patients with normal glucose tolerance (NGT) were enrolled study. An oral test performed 1 week before transplantation repeated at 7 years after transplantation. RESULTS—The overall 39% year 35.1% posttransplantation. The...
To our knowledge the effects of preoperative kidney volume in living donors on post-donation change size and function remaining have not been investigated. We studied association between volume, delayed recovery donors.From 2007 to 2008 we investigated 222 donors. Kidney before 6 months after surgery was estimated using voxel count method. analyzed correlations with patient characteristics, actual weight. identify predictors increase performed regression analysis.Mean +/- SD total 311.9 50.6...
Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP kidney transplantation recipients. We conducted retrospective analysis patient data from 500 consecutive transplants performed at Severance Hospital between April 2011 and 2014. Eighteen recipients (3.6%) were diagnosed with PJP. In the univariate analysis, acute graft rejection, CMV infection, use medication...
Background: Anti-angiotensin II type 1 receptor antibodies (AT1R-Abs) have been suggested as a risk factor for graft failure and acute rejection (AR). However, the prevalence clinical significance of pretransplant AT1R-Abs seldom evaluated in Asia. Methods: In this multicenter, observational cohort study, we tested serum samples obtained from 166 kidney transplant recipients. Statistical analysis was used to set threshold level at 9.05 U/mL. Results: Pretransplant were detected 98/166...
Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue are widely used examine the liver. However, relatively few studies have investigated use elastographic methods transplanted kidneys. The aim this study was explore clinical implications acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total 91 patients who underwent living donor transplantation between...
Rituximab (RIT) improves the outcomes of ABO-incompatible (ABOi) kidney transplantation (KT), but it has been associated with infectious complications. The aim this study was to investigate complications according dose RIT in ABOi KT. We analyzed 213 recipients [118 ABO-compatible (ABOc) KT and 95 KT] who underwent living donor between 2010 2014. patients were categorized by dose: standard (375 mg/m2, n = 76) versus reduced (200 mg, 19). All received basiliximab maintained on triple...
Transient receptor potential vanilloid 4 (TRPV4) is a mechanosensitive ion channel highly expressed in chondrocytes that supports cartilage development and homeostasis. Mutations the can cause skeletal dysplasias, including gain-of-function mutations V620I T89I lead to brachyolmia metatropic dysplasia, respectively. These suppress hypertrophic differentiation, but mechanisms by which they alter chondrocyte response mechanical load remain be elucidated. To determine effect of these on...
Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients, and insulin secretory defects play an important role the pathogenesis of PTDM. The R325W (rs13266634) nonsynonymous polymorphism islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 possibly defect secretion. This study investigated association between genetic variations SLC30A8 gene PTDM allograft recipients.A total 624 unrelated...
<i>Background/Aims:</i> Plasminogen activator inhibitor (PAI)-1 is increasingly recognized as a profibrotic factor but the mechanisms are not entirely clear. The present study examined mechanism of PAI-1 focusing on its effect transforming growth (TGF)-β1 in experimental diabetes. <i>Methods:</i> knockout (KO) mesangial cells cultured under high glucose (HG) addition to streptozotocin-induced diabetic KO mice were used. <i>Results:</i> deficiency did...
We investigated whether transplantation of a three-dimensional cell mass adipose-derived stem cells (3DCM-ASCs) improved hind limb functional recovery by the stimulation angiogenesis and neurogenesis in spinal cord injury. In in-vitro experiments, we confirmed that 3DCM-ASCs differentiated into CD31-positive endothelial cells. To evaluate therapeutic effect vivo, PBS, human adipose tissue-derived cells, were transplanted injury model. The injured remained differentiated. Transplantation...
Abstract The clinical outcomes of 2,054 renal recipients were examined retrospectively based on pre‐transplant hepatitis B surface antigen (HBsAg) status to investigate the efficacy lamivudine treatment in HBsAg positive recipients. Pre‐transplant positivity was documented 66 10‐year patient and graft survival rates Ag group significantly lower than those negative (64.4/36.6% vs. 88.2/70.5%, respectively, P < 0.0001). Since 1997, used when virus polymerase chain reaction (HBV PCR) or...