A5066279647- Lung Cancer Treatments and Mutations
- Protein Kinase Regulation and GTPase Signaling
- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation
- HER2/EGFR in Cancer Research
- Cytokine Signaling Pathways and Interactions
- Medical Imaging Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Biochemical and Molecular Research
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- Dialysis and Renal Disease Management
- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Mesenchymal stem cell research
- Heat shock proteins research
- Connective Tissue Growth Factor Research
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- Parathyroid Disorders and Treatments
- Genomics, phytochemicals, and oxidative stress
Yonsei University
1998-2024
Severance Hospital
2024
Pusan National University
2012-2023
Soonchunhyang University Hospital
2023
University of South China
2021-2022
Inha University
2015-2019
Kyungpook National University
2018
Institute for Basic Science
2016
Korea University
2016
Soon Chun Hyang University Cheonan Hospital
2009
ABSTRACT. Although high glucose (HG) has been shown to induce nuclear factor-κB (NF-κB) activation in vascular cells, the upstream regulation and biologic significance of NF-κB diabetic renal injury are not clear. It was, therefore, examined if HG-induced generation reactive oxygen species (ROS) protein kinase C (PKC) involved mesangial cells (MC), role monocyte chemoattractant protein-1 (MCP-1) expression by MC was further investigated. Recent observations suggest that MCP-1 may play a...
Excessive accumulation of extracellular matrix (ECM) in the kidneys and epithelial-to-mesenchymal transition (EMT) renal tubular epithelial cells contributes to fibrosis that is associated with diabetic nephropathy. Histone deacetylase (HDAC) determines acetylation status histones thereby controls regulation gene expression. This study examined effect HDAC inhibition on induced by diabetes or transforming growth factor (TGF)-beta1 determined role reactive oxygen species (ROS) as mediators...
Abstract Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in aged kidney, role interaction between Sirt1 hypoxia‐inducible factor (HIF)‐1α largely unknown. In this study, we investigated whether HIF‐1α could be a deacetylation target effect their on age‐associated renal injury. Five‐week‐old (young) 24‐month‐old (old) C57Bl/6J mice were assessed for changes. Kidneys from showed increased infiltration CD68‐positive macrophages, higher extracellular matrix...
Abstract Three generations of tyrosine kinase inhibitors (TKI) have been approved for anaplastic lymphoma (ALK) fusion–positive non–small cell lung cancer. However, none address the combined need broad resistance coverage, brain activity, and avoidance clinically dose-limiting TRK inhibition. NVL-655 is a rationally designed TKI with >50-fold selectivity ALK over 96% kinome tested. In vitro, inhibits diverse fusions, activating alterations, mutations, showing ≥100-fold improved...
Chronic kidney disease (CKD) is associated with increased risk for cardiovascular diseases (CVD). We hypothesized that inadequate angiogenic response in uremic patients could result from dysfunction of bone marrow-derived stromal cells [mesenchymal stem (MSCs)]. investigated whether MSCs are functionally competent uremia induced by partial ablation C57Bl/6J mice. Uremic showed decreased expression vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)1 and cell-derived (SDF)-1α,...
Recently, it has been reported that Fusobacterium nucleatum, a major pathogen involved in chronic periodontitis, may play an important role colorectal cancer (CRC) progression. In addition, inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease represent predisposing conditions for the development of CRC, this subtype is called colitis-associated (CAC). Although importance F. nucleatum CRC attracted attention, its exact related mechanism CAC progression remain unclear....
Mesenchymal stem cells (MSCs) are promising source of cell-based regenerative therapy. In consideration the risk allosensitization, autologous MSC-based therapy is preferred over allogenic transplantation in patients with chronic kidney disease (CKD). However, it remains uncertain whether adequate cell functionality maintained under uremic conditions. As inflammation and oxidative stress CKD may lead to accumulation senescent cells, we investigated cellular senescence MSCs determined effects...
MET amplification is a frequent mechanism of resistance to EGFR tyrosine kinase inhibitors (TKI) in patients with EGFR-mutated non-small cell lung cancer (NSCLC), and combined treatment TKIs has been explored as strategy overcome resistance. However, durable response invariably limited by the emergence acquired Here, we investigated preclinical activity REGN5093-M114, novel antibody-drug conjugate targeting MET-driven patient-derived models.
d-allulose is a rare sugar with zero energy that can be consumed by obese/overweight individuals. Many studies have suggested zero-calorie has beneficial effects on obesity-related metabolism in mouse models, but only few been performed human subjects. Therefore, we preliminary study 121 Korean subjects (aged 20–40 years, body mass index ≥ 23 kg/m2). A randomized controlled trial involving placebo control (sucralose, 0.012 g × 2 times/day), low (d-allulose, 4 and high 7 times/day) groups was...
Glucocorticoid (GC) receptor (GR) has been shown recently to bind a subset of mRNAs and elicit rapid mRNA degradation. However, the molecular details GR-mediated decay (GMD) remain unclear. Here, we demonstrate that GMD triggers degradation target in translation-independent exon junction complex-independent manner, confirming is mechanistically distinct from nonsense-mediated (NMD). Efficient requires PNRC2 (proline-rich nuclear coregulatory protein 2) binding, helicase ability, ATM-mediated...
Abstract Bone marrow-derived mesenchymal stem cells (BM-MSCs), the common progenitor of adipocytes and osteoblasts, have been recognized as key mediator during bone formation. Herein, our study aim to investigate molecular mechanisms underlying circular RNA (circRNA) AFF4 (circ_AFF4)-regulated BM-MSCs osteogenesis. were characterized by FACS, ARS, ALP staining. Expression patterns circ_AFF4, miR-135a-5p, FNDC5/Irisin, SMAD1/5, osteogenesis markers, including ALP, BMP4, RUNX2, Spp1, Colla1...
First-generation KRAS G12C inhibitors, such as sotorasib and adagrasib, are limited by the depth duration of clinical responses. One potential explanation for their modest activity is dynamic "cycling" between its guanosine diphosphate (GDP)- triphosphate (GTP)-bound states, raising controversy about whether targeting GDP-bound form can fully block this oncogenic driver. We herein report that D3S-001, a next-generation inhibitor with faster target engagement (TE) kinetics, depletes cellular...
To demonstrate the presence of an independent renin-angiotensin system (RAS) in peritoneum and to determine role locally produced angiotensin (Ang) II high glucose-induced upregulation transforming growth factor (TGF)-beta1 fibronectin by human peritoneal mesothelial cells (HPMC).In cultured HPMC, expression mRNAs for angiotensinogen, angiotensin-converting enzyme (ACE), Ang type 1 receptor (AT1), TGF-beta1 was evaluated real-time polymerase chain reaction; ACE, AT1, proteins Western blot...
<i>Background/Aims:</i> Plasminogen activator inhibitor (PAI)-1 is increasingly recognized as a profibrotic factor but the mechanisms are not entirely clear. The present study examined mechanism of PAI-1 focusing on its effect transforming growth (TGF)-β1 in experimental diabetes. <i>Methods:</i> knockout (KO) mesangial cells cultured under high glucose (HG) addition to streptozotocin-induced diabetic KO mice were used. <i>Results:</i> deficiency did...
Although mucoactive proteins, such as epidermal growth factor (EGF), could improve clinical outcomes of intestinal ulcerative diseases, their gastrointestinal application is limited because proteolytic digestion or concerns about tumor promotion. In the present study, ATP-binding cassette (ABC) transporter-linked secretion human EGF from probiotic Escherichia coli (EGF-EcN) was created to promote beneficial actions receptor, which notably attenuated in patients with injuries. Preventive and...
To investigate the biocompatibility of "new" peritoneal dialysis (PD) solutions with bicarbonate/lactate buffer, non glucose osmotic agents (icodextrin or amino acids), neutral pH, and low levels degradation products (GDPs).Using M199 culture medium as a control, we compared conventional new PD respect to their effects on viability human mesothelial cells (HPMCs) [using lactate dehydrogenase (LDH) release], DNA damage in HPMCs single-cell gel electrophoresis (Comet assay)], HPMC...
Curcumin, belonging to a class of natural phenol compounds, has been extensively studied due its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects. Recently, it shown exert dual activities after irradiation, radioprotection, radiosensitization. Here, we investigated the protective effect curcumin against radiation damage using D. melanogaster . Pretreatment with (100 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...