A5101818067- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Fibroblast Growth Factor Research
- Metastasis and carcinoma case studies
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Renal and related cancers
- 3D Printing in Biomedical Research
- Eosinophilic Disorders and Syndromes
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Kruppel-like factors research
Samsung Medical Center
2010-2020
Sungkyunkwan University
2011-2020
Samsung (South Korea)
2019
Kyung Hee University
2005
Patients with gastric and esophageal (GE) adenocarcinoma tumors in which the oncogene ERBB2 has been amplified are routinely treated a combination of cytotoxic chemotherapy ERBB2-directed antibody trastuzumab; however, addition trastuzumab, even when tested selected biomarker-positive patient population, provides only modest survival gains. To investigate potential reasons for impact therapies, we explored hypothesis that secondary molecular features ERBB2-amplified GE adenocarcinomas...
Abstract BACKGROUND: Recently, chromosomal rearrangements involving receptor tyrosine kinases (RTKs) have been described in common epithelial malignancies, including nonsmall cell lung cancer (NSCLC), colorectal cancer, and breast cancer. One of these RTKs, c‐ros oncogene 1, kinase (ROS1), has identified as a driver mutation NSCLC, because its inhibition by crizotinib, an anaplastic lymphoma (ALK)/met proto‐oncogene hepatocyte growth factor (MET)/ROS1 inhibitor, led to significant tumor...
Metastatic colorectal cancer (CRC) patients with v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are resistant to treatment cetuximab, a monoclonal antibody that targets the epidermal growth factor receptor. Statins have reported antitumor activity, but it is unknown whether simvastatin can reverse cetuximab resistance in KRAS mutant CRC. Human CRC cell lines (LS153, LS174T, DLD1, LoVo, SW403, SW480, SNU175, and LS1034) or v-raf murine B1 (BRAF) (DiFi, SW48, HT29, RKO)...
Chronic kidney disease (CKD) is associated with increased risk for cardiovascular diseases (CVD). We hypothesized that inadequate angiogenic response in uremic patients could result from dysfunction of bone marrow-derived stromal cells [mesenchymal stem (MSCs)]. investigated whether MSCs are functionally competent uremia induced by partial ablation C57Bl/6J mice. Uremic showed decreased expression vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)1 and cell-derived (SDF)-1α,...
Background Gastric cancer is one of the leading types in incidence and mortality, especially Asia. In order to improve survival, identification a catalogue molecular alterations underlying gastric critical step for developing designing genome-directed therapies. Methodology/Principal Findings The Center Cancer Genome Discovery (CCGD) at Dana-Farber Institute (DFCI) has adapted high-throughput genotyping platform determine mutation status large panel known genes. detection platform, termed...
Intestinal-type gastric carcinoma exhibits a multistep carcinogenic sequence from adenoma to with gradual increase in genomic alterations. But the roles of microRNAs (miRNA) this multistage cascade are not fully explored. To identify differentially expressed miRNA (DEM) during early carcinogenesis, we performed microarray profiling 24 cancers and precursor lesions (7 cancer [EGC], 3 adenomas high-grade dysplasia, 4 low-grade 10 adjacent normal tissues). Alterations expression 132 were...
Yun J, Lee Jang EJ, KT, Kim JH, K-M. KIT amplification and gene mutations in acral/mucosal melanoma Korea. APMIS 2011; 119: 330–5. Mucosal acral melanomas have demonstrated different genetic alterations biological behavior compared with more common cutaneous melanomas. It was recently reported that gain-of-function and/or copy number increases are mucosal Thus, we studied the frequency pattern of aberrations We analyzed 97 patients who were pathologically confirmed or between 1997 2010 at...
Recently, MET exon 14 deletion (METex14del) has been postulated to be one potential mechanism for protein overexpression. We screened the presence of METex14del transcript by multiplexed fusion analysis using nCounter assay followed confirmation with quantitative reverse transcription PCR correlation expression immunohistochemistry (IHC) and amplification fluorescence in situ hybridization (FISH). extracted RNAs from 230 patients enrolled onto prospective molecular profiling clinical trial...
// Su Jin Lee 1, * , Gang Gary Li 2, Seung Tae Kim Min Eui Hong 3 Jiryeon Jang 1 Nara Yoon Soo Ahn Danielle Murphy 2 Jason Christiansen Ge Wei Zachary Hornby Dong Woo 4 Joon Oh Park 7 Young Suk Ho Yeong Lim Sung No 5 Seok-Hyeong Won Ki Kang Keunchil Woong Yang 6 Kyoung-Mee 3, Jeeyun Division of Hematology-Oncology, Department Medicine, Samsung Medical Center, Sungkyunkwan University School Seoul, Korea Ignyta Inc, San Diego, California, USA Pathology and Translational Genomics, Electrics,...
P21-activated kinase 4 (PAK), a subfamily of serine/threonine kinases originally known as regulator cytoskeletal dynamics and cell motility, has recently been revealed to play key role in oncogenic signaling pathways. We studied the frequency clinical features PAK4-overexpressed metastatic gastric cancer.PAK4 overexpression was screened by Western blot 18 human cancer lines. Immunohistochemical staining PAK4 protein performed tumor specimens 49 patients who received palliative...
// Ji Yun Lee 1, * , Sun Young Kim Charny Park Nayoung K.D. 2, Jiryeon Jang 1 Kyunghee 2 Jun Ho Yi 7 Mineui Hong 3, 4 Taejin Ahn Oliver Rath 5 Julia Schueler Seung Tae In-Gu Do Sujin Se Hoon Yong Ick 6 Dukwhan Joon Oh 3 Suk Won Ki Kang Kyoung-Mee Woong-Yang Yeong Lim Jeeyun Division of Hematology-Oncology, Department Medicine, Samsung Medical Center, Sungkyunkwan University School Seoul, Korea Genome Institute, Innovative Cancer Medicine Pathology and Translational Genomics, Oncotest,...
// Sun Young Kim 1, * , Taejin Ahn 2, Heejin Bang 3, Jun Soo Ham 1 Jusun Seung Tae Jiryeon Jang Moonhee Shim So Kang 3 Se Hoon Park Byung Min 4 Hyuk Lee Won Ki Kyoung-Mee Woongyang 5 Jeeyun Division of Hematology-Oncology, Department Medicine, Samsung Medical Center, Sungkyunkwan University School Seoul, Korea 2 Genome Institute, Pathology and Translational Genomics, Gastroenterology, Molecular Cell Biology, These authors are contributed equally to this work Correspondence to: Lee, email:...
Growth factor receptors, often carrying tyrosine kinase activities in their cytoplasmic domains, are overexpressed many cancers. Coactivation of receptor kinases (RTKs) plays a critical role tumor response to targeted therapeutics. We examined concomitant overexpression EGFR and MET patients with HER2(+) HER2(-) gastric cancers (GCs). Tissue microarray samples obtained from 1,589 GC who received R0 gastrectomy extensive node dissection adjuvant chemoradiationtherapy were analyzed by...
Gastric carcinoma is one of the major causes cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas advanced (AGC) remains poor. It unclear whether EGCs AGCs are distinct entities or beginning stages AGCs. We performed whole exome sequencing four samples from EGC compared results those In both AGCs, a total 268 genes were commonly mutated independent mutations additionally found (516 genes) (3104...
Background Given the high incidence of metastatic esophageal squamous cell carcinoma, especially in Asia, we screened for presence somatic mutations using OncoMap platform with aim defining subsets patients who may be potential candidate targeted therapy. Methods and Materials We analyzed 87 tissue specimens obtained from 80 were pathologically confirmed carcinoma received 5-fluoropyrimidine/platinum-based chemotherapy. 4.0, a mass-spectrometry based assay, was used to interrogate 471...
The aim of this study was to utilize the proteomics-based Collaborative Enzyme Enhanced Reactive (CEER) immunoassay investigate protein tyrosine phosphorylations as diagnostic markers in gastric cancers (GCs).Protein lysates from fresh-frozen 434 advanced stage GCs were analyzed for phosphorylation HER1, HER2, p95HER2, HER3, cMET, IGF1R and PI3K. pathway activation patterns segregated based on tumor HER2 status. Hierarchical clustering utilized determine coactivations GCs. Prognostic value...
// Jeeyun Lee 1, * , Hee Cheol Kim 2, Jung Yong Hong 3, Kai Wang 4 Sun Young 1 Jiryeon Jang Seung Tae Joon Oh Park Ho Yeong Lim Won Ki Kang Suk Jiyun Woo 2 Yoon Ah Wook Huh Seong Hyeon Yun In-Gu Do 5 Seok Hyung Sohail Balasubramanian Philip J. Stephens Jeffrey S. Ross 4, 6 Gang Gary Li 7 Zachary Hornby Siraj M. Ali Vincent A. Miller Kyoung-Mee 5, 8 Sai-Hong Ignatius Ou 9 Department of Medicine, Division Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School Seoul,...
The aims of this study were to demonstrate the tumorigenicity CD133+ colon cancer cells in vitro, analyze correlations between spheroid formation and clinicopathologic variables, screen for overexpressed genes stem cells. Moreover, aim was establish a living tumor tissue bank using surgically resected specimens.Using LoVo cell line, we isolated performed clonogenic assay animal experiment test Twenty-nine surgical samples freshly collected from 27 patients who received curative or palliative...
// Jun Ho Yi 1, 5, * , Jiryeon Jang Jeonghee Cho 2, In-Gu Do 3 Mineui Hong 4 Seung Tae Kim 1 Kyoung-Mee Sujin Lee Se Hoon Park Joon Oh Young Suk Won Ki Kang Yeong Lim and Jeeyun Division of Hematology-Oncology, Department Medicine, Samsung Medical Center, Sungkyunkwan University School Seoul, Korea 2 Genome Institute, Pathology, Kangbuk Pathology Translational Genomics, 5 Hanyang Hospital, These authors have contributed equally to this work Correspondence to: Lim, e-mail: hoylim@skku.edu...
To investigate the prognostic role of estrogen receptor (ER) in gastric cancer (GC) patients, tumor tissues from 932 patients with advanced GC were assessed for ER expression using immunohistochemistry and their clinicopathologic features evaluated. Forty (4.3%) had they more frequently associated diffuse type shorter disease free survival. Furthermore, we carried out vitro analysis to evaluate effect modulation on proliferation cell lines. Estradiol enhanced positive cells while it did not...
Abstract Rhabdomyosarcoma (RMS) is the most commonly occurring type of soft tissue tumor in children. However, it rare adults and therefore, very little known about appropriate treatment strategy for adult RMS patients. We performed genomic analysis cells derived from a 27-year-old male patient whose disease was refractory to treatment. A peritoneal seeding nodule primary tumor, pleural metastases, malignant effusion ascites obtained during progression, were analyzed. Whole exome sequencing...
Biliary tract cancers (BTCs) are rare and heterogeneous group of tumors classified anatomically into intrahepatic extrahepatic bile ducts gallbladder adenocarcinomas. Patient-derived tumor cell (PDC) models with genome analysis can be a valuable platform to develop method overcome the clinical barrier on BTCs.Between January 2012 June 2015, 40 BTC patients' samples were collected. PDCs isolated cultured from surgical specimens, biopsy tissues, or malignant effusions including ascites pleural...