A5085440313- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renin-Angiotensin System Studies
- Vitamin D Research Studies
- Iron Metabolism and Disorders
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Central Venous Catheters and Hemodialysis
- Marine and coastal ecosystems
- Renal and related cancers
- Diabetes Treatment and Management
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- Pancreatitis Pathology and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Platelet Disorders and Treatments
- Muscle and Compartmental Disorders
- Immune cells in cancer
- Oceanographic and Atmospheric Processes
- Cancer-related molecular mechanisms research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chemokine receptors and signaling
- Pharmacological Effects and Toxicity Studies
- Blood Pressure and Hypertension Studies
Zhejiang Ocean University
2019-2024
Zhejiang University
2019-2024
South China Agricultural University
2022-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2014-2023
Sun Yat-sen University
2014-2023
University of Delaware
2019
The First Affiliated Hospital, Sun Yat-sen University
2001-2016
Soonchunhyang University
2003
Since renal fibrosis always predisposes end-stage disease, elucidation of the molecular mechanisms that underlie progression may substantially improve understanding and treatment for failure. Previous studies have highlighted an important counteraction between transforming growth factor β 1 (TGFβ1) bone morphogenic protein 7 (BMP7) in epithelial-to-mesenchymal transition (EMT) tubular epithelial cells during chronic injury. Macrophages are also believed to play a critical role fibrosis....
Urgent-start peritoneal dialysis (PD) can help patients with end-stage renal diseases (ESRD) that are referred late to dialysis. However, catheter patency and related complications of urgent-start PD have not been thoroughly clarified. We investigated the clinical outcomes in a Chinese cohort. enrolled ESRD who received (starting within 14 days after insertion) our center from January 1, 2006 December 31, 2014, followed them up for 10 years. The primary outcome was failure. Secondary...
Introduction Escherichia coli ( E. coli) peritonitis is a frequent, serious complication of peritoneal dialysis (PD). The extended-spectrum β–lactamase (ESBL)-producing associated with poorer prognosis and its incidence has been on continuous increase during the last decades. However, clinical course outcomes remain largely unclear. Methods All episodes that occurred in our unit from 2006 to 2011 were reviewed. polymicrobial excluded. Results In total, ninety monomicrobial 68 individuals,...
It has been confirmed that alternatively activated macrophages (M2) participate in tissue remodeling and fibrosis occurrence, but the effect of M2 on peritoneal related to dialysis (PD) hasn’t elucidated. This study was therefore conducted assess association between PD. In this study, induced by intraperitoneal (i.p.) injection Lactate-4.25% dialysate (100 mL/kg) C57BL/6J mice for 28 days, liposome-encapsulated clodronate (LC, specific scavenger macrophages) used treat model i.p. at day 18...
♦Objectives We aimed to prospectively compare the incidence of catheter-related complications and catheter survival for straight (SCs) coiled (CCs) Tenckhoff catheters in peritoneal dialysis (PD) patients. ♦Methods This open prospective randomized trial recruited 189 PD patients with end-stage renal disease from department nephrology, The First Affiliated Hospital Sun Yat-sen University 6 November 2007 27 August 2008. were a SC ( n = 99) or CC 90) then followed 2 years. All placements...
Background Peritoneal dialysis (PD) is developing rapidly in China, but because there are not enough well-trained PD doctors and nurses more rural areas, this expansion occurring mainly larger cities. To address imbalance, our center established a satellite program across Guangdong Province, with the aim of extending use improving quality PD. Methods Sun Yat-sen University responsible for running program. The centers selected using specific criteria. full-time physicians accept unified...
To analyze the clinicopathological features and therapeutic response of nephrotic IgA nephropathy (IgAN) patients with minimal-change disease (MCD).62 IgAN were enrolled between January 2002 December 2008, divided into two groups including Group A: MCD-like pathological features, B non-MCD pathologic pattern. The treatments, responses then analyzed.13 (21.0%) exhibited changes. Patients in A presented more prominent proteinuria, hypoalbuminemia but higher hemoglobin no incidence renal...
The rate of hepatitis B virus (HBV) infection is high in the Chinese population, and implications HBV are widely recognized, membranous nephropathy most common renal lesion to be associated with infection. Minimal change disease (MCD) one important histopathological characteristics patients nephrotic syndrome. There no any study report that etiology MCD. Herein, we four MCD speculate there an association pathological type In this study, also reported treatment schedule for these patients,...
Diabetic kidney disease (DKD) leads to the loss of renal function and cell cross-talk is one crucial mechanisms participating in pathogenesis DKD. However, communication were not fully elucidated previous studies. In this study, we performed analysis using CellPhoneDB based on a single-nucleus transcriptomic dataset (GSE131882) revealed associations between communication-related genes function, providing overall insight into addition, study may facilitate discovery novel mechanisms,...
The objective of the present study was to investigate role NADPH oxidase-dependent formation reactive oxygen species (ROS) in angiotensin II (Ang II)-induced epithelial-mesenchymal transition (EMT) and accumulation extracellular matrix (ECM) rat peritoneal mesothelial cells (RPMCs). Primary cultured RPMCs were incubated with serum-free media for 24 h order arrest synchronize cell growth. treated Ang (10-7 M) up 48 h. Cells pretreated an type I receptor antagonist (losartan, 10-5 M), or...
Peritoneal fibrosis is a major complication of continuous ambulatory peritoneal dialysis (CAPD). The present study tested the hypothesis that ADP-ribose polymerase-1 (PARP-1) may play role in epithelial-mesenchymal transition and under high glucose conditions. High (126 mmol/l)-induced EMT via PARP-1 mechanism was examined primary culture rat mesothelial cells (PMCs) human cell line (HMrSv5) presence or absence inhibitor PJ34 (3x10-6 M) by knocking down with siRNA technique. significantly...
SUMMARY Aim: This study investigated the role of NAD(P)H oxidase in transforming growth factor‐β1 (TGF‐β1)‐induced reactive oxygen species (ROS) generation, monocyte chemoattractant protein‐1 (MCP‐1), and interleukin‐6 (IL‐6) expression rat renal tubular epithelial NRK‐52E cells. Methods: The cells were treated with 10 ng/mL TGF‐β1, either presence or absence inhibitor, diphenyleneiodonium (DPI), short hairpin RNA (shRNA) suppressing p67phox expression. Expression subunits, MCP‐1, IL‐6 at...