A5103165685- Renal Diseases and Glomerulopathies
- Polyomavirus and related diseases
- Medicinal Plant Pharmacodynamics Research
- Chronic Kidney Disease and Diabetes
- Parvovirus B19 Infection Studies
- Renal Transplantation Outcomes and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Photocatalysis Techniques
- Healthcare professionals’ stress and burnout
- Estrogen and related hormone effects
- Autoimmune Bullous Skin Diseases
- Neurological disorders and treatments
- Growth Hormone and Insulin-like Growth Factors
- Chromium effects and bioremediation
- Organ Donation and Transplantation
- Vasculitis and related conditions
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Organ and Tissue Transplantation Research
- Natural product bioactivities and synthesis
- Phytoestrogen effects and research
- Pregnancy and Medication Impact
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Jinggangshan University
2022-2025
Qingdao University
2016-2025
Shenzhen University
2023-2024
Nanjing General Hospital of Nanjing Military Command
2023-2024
Shandong First Medical University
2024
Affiliated Hospital of Taishan Medical University
2024
Southwest University of Science and Technology
2024
Chinese Academy of Sciences
2024
Social vulnerability emphasizes the different burdens of disaster losses within and between places. Although China continuously experiences devastating natural disasters, there is a paucity research specifically addressing multidimensional nature social vulnerability. This article presents an initial study on Yangtze River Delta region in China. The goal to replicate test applicability place-based Vulnerability Index (SoVI®) developed for United States Chinese cultural context. Twenty-nine...
Background Programmed cell death 1 (PD-1) blockade induces tumor regression in patients with advanced esophageal squamous carcinoma (ESCC); however, little is known about the efficacy of PD-1 as neoadjuvant therapy resectable ESCC. We aim to assess safety and feasibility using combination chemotherapy Methods Patients previously untreated, (stage II or III) ESCC were enrolled. Each patient received two 21-day cycles treatment camrelizumab, nab-paclitaxel, carboplatin before undergoing...
Inhibitors of human methionine aminopeptidase type 2 (hMetAP2) are interest as potential treatments for cancer. A new class small molecule reversible inhibitors hMetAP2 was discovered and optimized, the 4-aryl-1,2,3-triazoles. Compound 24, a potent inhibitor cobalt-activated hMetAP2, also inhibits mouse endothelial cell growth. Using matrigel model, this shown to inhibit angiogenesis in vivo.
<i>Background:</i> Hyperuricemia is an independent risk factor for renal progression in IgA nephropathy (IgAN). However, no study has evaluated the effect of allopurinol on clinical outcome hyperuricemic IgAN. <i>Methods:</i> First,a retrospective cohort 353 IgAN patients was conducted to explore relationship between uric acid (UA) and disease over a mean period 5 years. Then, 40 were randomized receive (100–300 mg/day) or usual therapy 6 months. The outcomes and/or...
Crescentic IgA nephropathy (IgAN), defined as >50% crescentic glomeruli on kidney biopsy, is one of the most common causes rapidly progressive GN. However, few studies have characterized this condition. To identify risk factors and develop a prediction model, we assessed data from patients ≥ 14 years old with IgAN who were followed 12 months. The discovery cohort comprised 52 center, validation 61 multiple centers. At mean serum creatinine (SCr) level ± SD was 4.3 3.4 mg/dl, percentage...
Empathy of medical students is crucial, yet it tends to decline as enter later academic years. appeared be affected by the learning environment (LE), which could a potential contributor. We conducted cross-sectional study investigate association between LE and empathy. The comprised overall 10,901 from 12 Chinese schools. Jefferson Scale (JSE) was utilized assess empathy, while 5-point question Johns Hopkins Learning Environment were employed evaluate LE. JSE scores compared across levels...
Abstract Endothelial-to-mesenchymal transition (EndMT) can cause loss of tight junctions, which in glomeruli are associated with albuminuria. Here we evaluated the role EndMT development albuminuria diabetic nephropathy (DN). We demonstrated that occurs glomerular endothelium patients DN, showing by a decrease CD31 but an increase α-SMA expression. In db / mice, there was increased ROCK1 expression plus decreased CD31-positive cells. Cultured endothelial cells (GEnCs) underwent when...
Objective Several studies have reported that tacrolimus (TAC) significantly reduced proteinuria in lupus nephritis (LN) patients and mouse models. However, the mechanism for this effect remains undetermined. This study explored of how TAC protects podocytes from injury to identify new targets protecting renal function. Methods MRL/lpr mice were given at a dosage 0.1 mg/kg per day by intragastric administration 8 weeks. Urine blood samples collected. Kidney sections (2μm) stained with...
Autophagy dysfunctions are involved in the pathogenesis of Parkinson’s disease (PD). In present study, we aimed to evaluate involvement G protein-coupled estrogen receptor (GPER) inhibitory effect insulin-like growth factor-1 (IGF-1) against excessive autophagy PD animal and cellular models. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment significantly induced mouse movement disorder decreased protein level tyrosine hydroxylase (TH) substantia nigra (SN) dopamine (DA) content...
BackgroundImproved markers for predicting recurrence are needed to stratify patients with localised (stage I–III) renal cell carcinoma after surgery selection of adjuvant therapy. We developed a novel assay integrating three modalities—clinical, genomic, and histopathological—to improve the predictive accuracy recurrence.MethodsIn this retrospective analysis validation study, we histopathological whole-slide image (WSI)-based score using deep learning allied digital scanning conventional...
In this study, two Cr(VI)-reducing functional bacterial strains (TJ-1 and TJ-5) were successfully isolated screened from the chromium-contaminated soil a real site. The 16S rRNA gene sequences analysed, which showed high similarity (>99%) with Stenotrophomonas maltophilia (TJ-1) Brucella intermedius (TJ-5) species. optimum growth for bacteria to reduce Cr(VI) achieved at pH 7.0 initial inoculation amount of 5%. applied contaminated samples better Cr removal when external carbon sources...
Abstract Background Esophageal cancer (EC) is a global canker notorious for causing high mortality due to its relentless incidence rate, convoluted with unyielding recurrence and metastasis. However, these intricacies of EC are associated an immoderate expression NY-ESO-1 antigen, presenting lifeline adoptive T cell therapy. We hypothesized that naturally isolated higher-affinity receptors (TCRs) bind would allow lymphocytes target pronounced antitumor response efficacy. Also, targeting...
Physiological concentration of genistein, a natural isoflavonoid phytoestrogen, stimulates human breast cancer (MCF-7) cells proliferation. In this study, we hypothesize that low genistein mimics the action 17β-estradiol in stimulation MCF-7 cell growth by enhancement IGF-I signaling pathway. Genistein, at 1 μm, stimulated cells. Cell cycle analysis showed μm significantly increased S phase and decreased G0G1 The protein mRNA expression receptor (IGF-IR) insulin substrate (IRS)-1, but not...