A5026930577- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Engineering Applied Research
- Organ Donation and Transplantation
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Transplantation: Methods and Outcomes
- Diverse Approaches in Healthcare and Education Studies
- Acute Kidney Injury Research
- MicroRNA in disease regulation
- Marine and Coastal Research
- Cancer-related molecular mechanisms research
- Complement system in diseases
- Neurological Complications and Syndromes
- RNA modifications and cancer
- Renal and Vascular Pathologies
- Cytomegalovirus and herpesvirus research
- Diabetes Treatment and Management
- Agriculture, Soil, Plant Science
- Parathyroid Disorders and Treatments
- Diverse Topics in Contemporary Research
- Pregnancy and Medication Impact
- Technology and Data Analysis
- Erythropoietin and Anemia Treatment
Seoul National University Bundang Hospital
2020-2025
Kangbuk Samsung Hospital
2025
Sungkyunkwan University
2025
Gachon University
2025
Seoul National University
2010-2024
Canadian Institute for Health Information
2024
Korea University Medical Center
2024
University of Chicago
2024
Dankook University Hospital
2023
Seoul National University Hospital
2008-2021
For classification with small training samples and high dimensionality, feature selection plays an important role in avoiding overfitting problems improving performance. One of the commonly used methods for is recursive elimination (RFE) method. RFE method utilizes generalization capability embedded support vector machines thus suitable problems. Despite its good performance, tends to discard "weak" features, which may provide a significant improvement performance when combined other...
Urinary tract infection (UTI) occurs in 30%-50% of individuals with autosomal dominant polycystic kidney disease (ADPKD). However, the clinical relevance asymptomatic pyuria ADPKD patients remains unknown.We retrospectively reviewed medical records 256 who registered to clinic at Seoul National University Hospital from Aug 1999 2010. We defined as more than 5-9 white blood cells high-power field no related symptoms or signs overt UTI. Patients were categorized into 2 groups depending on its...
Background. The efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT2i) have not been investigated in kidney transplant recipients (KTRs) with diabetes. We evaluated the impact SGLT2i a multicenter cohort diabetic KTRs. Methods. A total 2083 KTRs diabetes were enrolled from 6 centers Korea. Among them, 226 (10.8%) patients prescribed for >90 d. primary outcome was composite all-cause mortality, death-censored graft failure (DCGF), serum creatinine doubling. An acute dip...
Regulatory T cells (Tregs) can suppress immunologic damage in renal ischemia-reperfusion injury (IRI), but the isolation and ex vivo expansion of these for clinical application remains challenging. Here, we investigated whether IL-2/anti-IL-2 complex (IL-2C), a mediator Treg expansion, attenuate IRI mice. IL-2C administered before bilateral induced both spleen kidney, improved function, attenuated histologic apoptosis after IRI. Furthermore, administration reduced expression inflammatory...
Kidney transplantation (KT) improves the cardiovascular outcomes of patients with end-stage kidney disease. However, disease remains leading cause premature death and graft loss in KT recipients (KTRs) diabetes. We evaluated cardioprotective effects sodium-glucose cotransporter 2 inhibitors (SGLT2i) KTRs
Abstract Metformin is the primary treatment for type 2 diabetes mellitus (T2DM) due to its effectiveness in improving clinical outcomes patients with preserved renal function, however, evidence on of metformin various functions lacking. We performed a retrospective, multicenter, observational study used data T2DM obtained from three tertiary hospitals’ databases. Patients given within run-in periods and at least one additional prescription formed cohort. A control cohort comprised those...
The outcomes after kidney transplantation (KT), including access, wait time, and other issues around the globe, have been studied. However, do vary from one country to another.
Background: Anti-angiotensin II type 1 receptor antibodies (AT1R-Abs) have been suggested as a risk factor for graft failure and acute rejection (AR). However, the prevalence clinical significance of pretransplant AT1R-Abs seldom evaluated in Asia. Methods: In this multicenter, observational cohort study, we tested serum samples obtained from 166 kidney transplant recipients. Statistical analysis was used to set threshold level at 9.05 U/mL. Results: Pretransplant were detected 98/166...
Beneficial aspects of solid organ transplantation, which encompass survival benefit, improved quality life, and cost efficacy, have been clearly demonstrated. However, regional ethnic differences require further studies to identify prognostic factors transplant outcomes against various backgrounds. After previous efforts a nationwide, retrospective study on the kidney in Korea, new prospective-designed version Korean Organ Transplantation Registry (KOTRY) was launched 2014.Cohorts kidney,...
Abstract We investigated the effects of pregnancy and delivery on renal function in transplant recipients relationship between doses immunosuppressants blood drug levels during 75 women with 88 deliveries. Significant serum creatinine elevation (> 0.5 mg/dL) was found eight In remaining 80 cases, reduced by an average 0.14 mg/dL returned to pre‐pregnant after delivery. Tacrolimus used 28 deliveries cyclosporine others. trough level declined from 5.8 ± 2.8 ng/mL 12 months before 4.2 1.8 at...
Transplant centers seeking to increase coronavirus disease 2019 (COVID-19) vaccine coverage may consider requiring vaccination for healthcare workers or candidates. The authors summarize current data inform an ethical analysis of the harms, benefits, and individual societal impact mandatory vaccination, concluding that requirements transplant candidates are ethically justified by beneficence, net utility, fiduciary duty patients public health. Implementation strategies should mitigate...
Acute kidney injury (AKI) is commonly encountered in clinical practice and associated with poor patient outcomes increased health care costs. Despite it posing significant challenges for clinicians, effective measures AKI prediction prevention are lacking. Previously published models mostly have a simple design without external validation. Furthermore, little known about the process of linking model output decisions due to black-box nature neural network models.We aimed present an externally...
Combination therapy of intravenous immunoglobulin (IVIG) and rituximab showed a good transplant rate in highly sensitized wait-listed patients for deceased donor kidney transplantation (DDKT), but carried the risk antibody-mediated rejection. The authors investigated impact new combination bortezomib, IVIG, on rate. This study was prospective, open-labeled clinical trial. desensitization regimen consisted 2 doses IVIG (2 g/kg), single dose (375 mg/m2), 4 bortezomib (1.3 mg/m2). analyzed....
Background The National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) developed new race-free eGFR equations recommended using these in 2021. However, clinical implication is not determined Korean adults. Thus, this study aimed to evaluate performances predicting complications chronic kidney disease (CKD) patients. Methods This analyzed 1,727 participants from KNOW-CKD cohort. We selected anemia, hyperkalemia, acidosis, hyperphosphatemia, hyperparathyroidism as five...
The kidney donor profile index (KDPI) is a valuable prognostic tool in deceased transplantation (DDKT), while its optimization for each country using local data essential. It remains unclear which patients derive survival benefits from expanded criteria (ECD) DDKT compared to waitlist or standard (SCD) DDKT, particularly the context of long waiting times. This study aimed develop kidneys and propose identify suitable candidates ECD Korea. Two prediction models were developed two cohorts...
Korean chronic kidney disease (CKD) patients have relatively low cardiovascular (CVD) and high end stage (ESKD) incidence rates. Using the multi-state model this study analyzed 5- 10-year cumulative hazard estimates, transition probabilities risk factors associated with five clinical transitions; ESKD, CVD, CVD to death, ESKD death death. CKD stages 1–4 from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease cohort were included. Multivariable analysis was performed...
Abstract Background In recent years, symptomatic hepatitis A virus ( HAV ) infection has been reported with increasing frequency in Korea. Therefore, vaccination should be considered kidney transplant recipients KTR s). The study investigated the efficacy and safety of s under modern triple immunosuppressive agents. Methods We evaluated seroprevalence anti‐ immunoglobulin‐G (IgG) who had visited Seoul National University Hospital from March 2011 to August 2012. Seronegative patients were...
For phosphate control, patient education is essential due to the limited clearance of by dialysis. However, well-designed randomized controlled trials about dietary and binder have been scarce.We enrolled maintenance hemodialysis patients them into an group (n = 48) or a control 22). We assessed patients' drug compliance their knowledge using questionnaire.The primary goal was increase number who reached calcium-phosphorus product lower than 55. In group, 36 (75.0%) achieved goal, as...
Coronavirus disease 2019 (COVID-19) has had a major impact on global communities and healthcare.Paxlovid (nirmatrelvir/ritonavir) is an oral drug for the treatment of COVID-19 that been approved by U.S. Food Drug Administration.In Korea, Paxlovid first-line patients who are >60 years old or using immunosuppressants, those >40 with chronic diseases such as obesity, diabetes, kidney disease, hypertension.One caveat potential risk interaction it strong cytochrome P450 (CYP) 3A P-glycoprotein...
Cytomegalovirus (CMV) infection is a frequent complication after kidney transplantation (KT) and has various effects on recipient graft survival. Although guidelines recommend anti-viral prophylaxis with ganciclovir or valganciclovir, there demand for alternative regimen CMV prevention. We investigated the of 3-month valacyclovir-based clinical outcomes in KT recipients using nationwide cohort. Overall, 2,584 from 20 transplant centers registered Korean Organ Transplantation Registry between...
Abstract Background We performed a retrospective cohort study to determine the prognostic value of standard criteria donor/expanded donor ( SCD / ECD ) designation, with regard one‐yr GFR and graft survival rate, in region short, cold ischemic time CIT ), how this designation compares kidney risk index KDRI zero‐time biopsies. Methods reviewed 362 cases deceased transplantation DDKT ). Donor kidneys were classified as or . They also assessed by Zero‐time biopsy was 196 patients, histologic...