Little is known about the prevalence of chronic kidney disease (CKD) during coronavirus 2019 (COVID-19) pandemic. We aimed to investigate long-term trends in CKD from South Korea including early used data 108,152 Korean adults 2007 2020 obtained a representative longitudinal serial study. defined as condition when participant's estimated glomerular filtration rate was < 60 mL/min/1.73 m2, or one-time spot proteinuria ≥ 1 +, and then examined overall CKD. Among included (n = 80,010), national...

In 2009, the Oxford classification was developed as a pathological system for immunoglobulin A nephropathy (IgAN) to predict risk of disease progression. The aim this retrospective study evaluate clinical and pathologic relevance in Korean patients with diagnosis IgAN. We reviewed renal pathology archives from January 2000 December 2006 at Seoul St Mary's Hospital Korea identified 273 patients, who were diagnosed having enrolled 197 available further clinicopathologic analysis. All cases...

The authors have developed a semitransparent, multilayered cathode of indium tin oxide (ITO)/Ag/tungsten (WO3) for transparent organic light-emitting diodes. device showed weak negative differential resistance (NDR), until the operating voltage 8V was reached. NDR due to resonant tunneling by both quantum barrier and well. silver (Ag2O) on Ag metal confirmed x-ray photoelectron spectroscopy, energy levels Ag2O were quantized size effect this produced channels. using ITO∕Ag∕WO3 with LiF∕Al...

Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, two most commonly used methods assessing performance. obtained data regarding strength from 277 evaluated their relationships baseline parameters, mental health, plasma inflammatory markers, major adverse outcomes. was defined by recommendations suggested Asian Working Group on Sarcopenia. The prevalence...

Abstract Background IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis, although definitive markers are unknown. We aimed to investigate clinical significance urinary cytokines in patients with IgAN. Methods From 2009 2018, were divided into three groups: IgAN ( n = 191), disease control 53), and normal 76). used a multiplex enzyme-linked immunosorbent assay measure 16 selected inflammatory cytokines, evaluated correlation between pathological features following...

Residual kidney function (RKF) contributes to improved survival in hemodialysis (HD) patients. However, it is not clear whether RKF allows a comparable rate patients undergoing twice-weekly HD compared with thrice-weekly HD. We enrolled 685 from prospective multicenter observational cohort. and adequacy was monitored regularly over 3-year follow-up. Patients were divided into groups (n = 113) or 137). without 435) included as controls. Fluid balance dialysis-associated characteristics...

Triglyceride-glucose (TyG) index has recently been established as an indicator of insulin resistance and predictive value for cardiovascular (CV) disease. However, the clinical significance TyG in patients undergoing hemodialysis remains unknown. We prospectively enrolled 759 maintenance hemodialysis. The participants were divided into tertiles based on their baseline index. Echocardiographic parameters, vascular calcification scores, several plasma biomarkers obtained compared using was...

Abstract Purpose Triglyceride-glucose (TyG) index is a reliable marker of insulin resistance. Although the TyG useful for identifying individuals at high risk future cardiovascular events and mortality in general population, its clinical impact on young adults remains unclear. This study aimed to investigate association between individuals. Methods We enrolled 6,667,138 aged 20-39 years who underwent Korean national health screening 2009 2012. Participants were categorized into quartiles...

Red blood cell distribution width (RDW) is a robust marker of adverse clinical outcomes in various populations. However, the significance progressive rise RDW undetermined end-stage renal disease (ESRD) patients. The purpose this study was to determine prognostic importance change ESRD Three hundred twenty-six incident dialysis patients were retrospectively analyzed. Temporal changes during 12 months after initiation assessed by calculating coefficients linear regression. Patients divided...

Introduction: A recent study showed that early renal tubular injury is ameliorated in Nod-like receptor pyrin domain-containing protein 3 (NLRP3) KO mice with rhabdomyolysis-induced acute kidney (RIAKI). However, the precise mechanism has not been determined. Therefore, we investigated role of NLRP3 cells RIAKI. Methods: Glycerol-mediated RIAKI was induced and wild-type (WT) mice. The were euthanized 24 h after glycerol injection, both kidneys plasma collected. HKC-8 treated ferrous...

The aim of this study is to investigate the clinical significance ratio between interleukin-17 (IL-17) secreting cell and FOXP3-positive regulatory T (FOXP3(+) Treg) infiltration in renal allograft tissues with acute T-cell-mediated rejection (ATCMR). Fifty-six patients biopsy-proven ATCMR were included. Infiltration FOXP3(+) Treg IL-17-secreting cells was evaluated immunostaining for FOXP3 or IL-17 on biopsy specimens, divided into high group (Log FOXP3/IL-17 > 0·45) < 0·45). We compared...

The effect of paricalcitol on renal ischemia-reperfusion injury (IRI) has not been investigated. We examined whether is effective in preventing inflammation a mouse model IRI, and evaluated the cyclooxygenase-2 (COX-2) prostaglandin E2 (PGE2) pathways as protective mechanism paricalcitol.Paricalcitol (0.3 μg/kg) was administered to male C57BL/6 mice 24 h before IRI. Bilateral kidneys were subjected 23 min ischemia, killed 72 after effects IRI terms function, tubular necrosis, apoptotic cell...

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for the prevention of cardiovascular (CV) events. However, clinical significance circulating PCSK9 unclear in hemodialysis (HD) patients. A total 353 HD patients were prospectively enrolled from June 2016 to August 2019 K-cohort. Plasma level was measured at time study enrollment. The primary endpoint defined as composite CV event and death. positively correlated with cholesterol statin treatment. Multivariate...

Background: Endostatin is released during extracellular matrix remodeling and involved in the development of vascular pathology cardiovascular (CV) disease. However, role circulating endostatin as a biomarker calcification CV events patients undergoing hemodialysis (HD) remains unclear. Methods: A total 372 HD were prospectively recruited. Plasma levels measured at baseline, their associations with mineral bone disease (MBD) biomarkers abdominal aortic scores analyzed. The primary endpoint...

Background. The aim of this study was to observe the effect sirolimus (SRL) on calcineurin inhibitor (CNI)-induced nephrotoxicity in aging process by using renal expression KLOTHO, an antiaging gene. Methods. Mice were treated with vehicle (VH; 1 mL/kg/day olive oil), cyclosporine A (CsA; 30 mg/kg/day), or tacrolimus (FK; mg/kg/day) without SRL (0.3 for 2 weeks. KLOTHO evaluated reverse-transcriptase polymerase chain reaction, immunoblotting, and immunohistochemistry. Oxidative stress...

Tenofovir disoproxil fumarate (TDF) is widely used as an effective first‐line therapy for chronic hepatitis B (CHB) infection. While TDF demonstrates successful viral suppression, it has been linked to the development of renal proximal tubular (PT) dysfunction, leading Fanconi syndrome. However, syndrome rarely reported in CHB‐monoinfected patients, and there were no reports TDF‐associated nephrotic Here, we report a case combined CHB patients after exposure. (H epatology 2015;62:1318‐1320)

Abstract Background Rifampin is one of the most important drugs in first-line therapies for tuberculosis. The renal toxicity rifampin has been reported sporadically and acute tubulointerstitial nephritis (ATIN) a frequent histological finding. We describe first time case ATIN Fanconi syndrome presenting as hypokalemic paralysis, associated with use rifampin. Case presentation A 42-year-old man was admitted sudden-onset lower extremity paralysis mild insufficiency. He had treated pulmonary...

Cilastatin (CL) is an inhibitor of dehydropeptidase-I, which safely used in clinical practice to prevent nephrotoxicity antibiotics. Tacrolimus (TAC) the most important immunosuppressant renal transplantation, but it causes considerable nephrotoxicity. We evaluated protective effects CL against chronic TAC-induced nephropathy. Chronic nephropathy was induced by administering TAC (1.5 mg/kg/ day, subcutaneous injection) rats on a low-salt diet for 4 weeks. (75 or 150 mg/kg/day,...

Abstract Numerous designs for tunneled hemodialysis catheter have been developed in an effort to improve function and survival. In this prospective randomized controlled study, 97 patients were into the palindrome group (PC, n = 47) step‐tip (SC, 50). Demographic characteristics not different between two groups. The effective blood flow rates at pump speeds comparable recirculation was low within acceptable range both types of catheter, adequacy However, when arterial venous lines reversed,...

Abstract This study aims to figure out the worldwide prevalence of anticancer therapy-associated acute kidney injury (AKI) and tubulointerstitial nephritis (TIN) relative risk each cancer drug. We conducted an analysis VigiBase, World Health Organization pharmacovigilance database, 1967–2023 via disproportionate Bayesian reporting method. further categorized drugs into four groups: cytotoxic therapy, hormone immunotherapy, targeted therapy. Reporting odds ratio (ROR) information component...