A5072255737- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Orthopaedic implants and arthroplasty
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Dental materials and restorations
- Preterm Birth and Chorioamnionitis
- Maternal and fetal healthcare
- Birth, Development, and Health
- Gout, Hyperuricemia, Uric Acid
- Congenital Anomalies and Fetal Surgery
- Periodontal Regeneration and Treatments
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Cardiovascular Issues in Pregnancy
- Electrospun Nanofibers in Biomedical Applications
- Renal and Vascular Pathologies
- Maternal and Perinatal Health Interventions
- Organ Transplantation Techniques and Outcomes
- Pediatric Urology and Nephrology Studies
- Chronic Kidney Disease and Diabetes
Gachon University Gil Medical Center
2014-2024
Catholic University of Korea
2015-2024
Deleted Institution
2010-2024
Daejeon St. Mary's Hospital
2015-2022
Gachon University
2000-2022
Uijeongbu St. Mary's Hospital
2021
Yeungnam University
2004-2018
Soonchunhyang University Hospital
2017
YKK (Japan)
2016
The Yeats Society of Korea
2016
We report here our 10-year experience of a biopsy performed at day 14 after transplantation in 304 patients with stable graft function. The factors that may have influenced subclinical rejection were analyzed according to histology. incidence was 13.2%. Addition mycophenolate mofetile (MMF) as primary immunosuppressant significantly decreased the compared without such treatment (odds ratio, 0.23; p < 0.05). On other hand, HLA-DR antigen mismatch 2.39) and unrelated donor 2.10) also...
Xanthine oxidase (XO) is an important source of reactive oxygen species. This study investigated whether XO inhibition exerts renoprotective effects by inhibiting vascular endothelial growth factor (VEGF) and NADPH (NOX) in diabetic kidney disease (DKD). Febuxostat (5 mg/kg) was administered to streptozotocin (STZ)-treated 8-week-old male C57BL/6 mice via intraperitoneal injection for 8 weeks. The cytoprotective effects, its mechanism inhibition, usage high-glucose (HG)-treated cultured...
This study aimed to investigate the association between serum levels of 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome along with its associated risk factors in Korean postmenopausal women. was performed using data from KNHANES 2008-2010 included 4,364 Clinical other objective characteristics, seasonality, presence five components were evaluated correlated 25(OH)D. Although no statistically significant associations observed 25(OH)D prevalence syndrome, adjusted OR for elevated blood...
Residual kidney function (RKF) contributes to improved survival in hemodialysis (HD) patients. However, it is not clear whether RKF allows a comparable rate patients undergoing twice-weekly HD compared with thrice-weekly HD. We enrolled 685 from prospective multicenter observational cohort. and adequacy was monitored regularly over 3-year follow-up. Patients were divided into groups (n = 113) or 137). without 435) included as controls. Fluid balance dialysis-associated characteristics...
2][3] Infection with HPV causes disruption of the host's E2 gene, resulting in expression viral oncogenes, E6 and E7.The E7 products inhibit activities tumor suppressors, p53 retinoblastoma protein, respectively.5] Although cervical cancer is 1 highest mortality female patients worldwide, it a curable disease when diagnosed at an early stage. 6However, clear prognostic factors for development are not yet existence.Mitochondria, which cell organelles involved processes life death tumoral...
Abstract Xanthine oxidoreductase (XOR) contributes to reactive oxygen species production. We investigated the cytoprotective mechanisms of XOR inhibition against high glucose (HG)-induced glomerular endothelial injury, which involves activation AMP-activated protein kinase (AMPK). Human cells (GECs) exposed HG were subjected febuxostat treatment for 48 h and expressions AMPK its associated signaling pathways evaluated. HG-treated GECs increased xanthine oxidase/xanthine dehydrogenase levels...
Patients with gestational diabetes mellitus (GDM) have been reported to exhibit the same genetic susceptibility as that observed in those type 2 (T2DM). Recent polymorphism studies shown several genes are related T2DM and GDM. The aim of this study was examine whether certain candidate genes, previously be associated T2DM, also offer a specific predisposition GDM.The current conducted 136 Korean pregnant women, who gave birth at Gil Hospital, from October 2008 May 2011. These subjects...
Acute pancreatitis in pregnancy is rare and occurs approximately 3 10,000 pregnancies. It rarely complicates pregnancy, can occur during any trimester, however over half (52%) of cases the third trimester post-partum period. Gallstones are most common cause acute pancreatitis. On other hand, caused by hypertriglyceridemia due to increase estrogen gestational period very unusual, but complication carries a higher risk morbidity mortality for both mother fetus. We experienced case pregnant...
Parathyroid hormone (PTH) is an important factor influencing immunologic dysfunction, but the effect of PTH level on infection-related outcomes remains unclear in incident dialysis.We evaluated a multicenter prospective cohort study 1,771 dialysis patients (1,260 hemodialysis and 511 peritoneal dialysis) Korea. Patients were divided into three groups based serum intact (iPTH) level. The primary all-cause mortality multivariate Cox regression analysis was performed to evaluate role iPTH...
In experimental animals and humans, hypothyroidism is associated with fluid retention generalized oedema, increased antidiuretic hormone (ADH), decreased atrial natriuretic (ANH), renin-angiotensin-aldosterone system (RAAS), which subsequently can be corrected by thyroid replacement. The purpose of this study was to determine the effect thyroxine therapy on RAAS neurohormones affecting water electrolyte metabolism reason for these changes in patients primary myxoedema.We measured plasma...
<i>Background:</i> C-reactive protein (CRP), which reflects chronic inflammation, is a strong predictor of cardiovascular mortality in hemodialysis patients. We investigated whether persistent elevation CRP associatedwith cardiac function and morphology patients maintained on hemodialysis. <i>Methods:</i> Predialysis high-sensitivity (hs-CRP) was measured twice at an interval 3 weeks 52 stable patients, echocardiographic studies were performed....
Erythropoietin was recently shown to exert important cytoprotective and anti-apoptotic effects in injury models of the brain, heart kidney. We examined whether erythropoietin also attenuates renal a rat model unilateral ureteral obstruction via anti-inflammatory actions.We divided Sprague-Dawley rats (Korea Research Institute Bioscience Biotechnology, Daejeon, Korea) into 4 groups, including 1-vehicle treated with sham operation, 2-vehicle for 3 days, 3-erythropoietin treatment operation...
Abstract Background Rifampin is one of the most important drugs in first-line therapies for tuberculosis. The renal toxicity rifampin has been reported sporadically and acute tubulointerstitial nephritis (ATIN) a frequent histological finding. We describe first time case ATIN Fanconi syndrome presenting as hypokalemic paralysis, associated with use rifampin. Case presentation A 42-year-old man was admitted sudden-onset lower extremity paralysis mild insufficiency. He had treated pulmonary...
Hypoalbuminemia frequently occurs in Hemorrhagic Fever with Renal Syndrome (HFRS), but clinical significance of hypoalbuminemia is not well known. This study was designed to evaluate as a marker severity disease patients HFRS. We evaluated the relationship between level serum albumin and parameters representing 144 The were divided into three groups based on albumin; Group I (normal albumin), II (serum <3.5 g/dL >/=3.0 g/dL), III <3.0 g/dL). Of total patients, 42 (29.2%) categorized I, 39...
The protective mechanism of paricalcitol remains unclear in renal ischemia-reperfusion (IR) injury. We investigated the renoprotective effects IR injury through prostaglandin E2 (PGE2) receptor EP4. Paricalcitol was injected into IR-exposed HK-2 cells and mice subjected to bilateral kidney ischemia for 23 min reperfusion 24 hr. prevented IR-induced cell death EP4 antagonist cotreatment offset these effects. increased phosphorylation Akt cyclic AMP responsive element binding protein (CREB)...
Background and Aim: Patients with chronic kidney disease (CKD) often have subclinical hypothyroidism.However, few reports investigated changes in the status of hypothyroidism CKD patients its clinical significance progression.Methods: We included 168 nondialysis-dependent stages 2-4.The normalization during follow-up was assessed, association between transitions hypothyroid rate decline estimated glomerular filtration (eGFR) investigated.Results: At baseline, 127 were euthyroid 41 (24.4%)...
<b><i>Background/Aims:</i></b> Atrial fibrillation (AF) often coexists with acute myocardial infarction (AMI), and chronic kidney disease (CKD) is a major risk for AMI. However, the combined impact of CKD AF on mortality morbidity in AMI population has not been determined. <b><i>Methods:</i></b> Between January 2004 December 2009, total 4,738 patients were enrolled prospectively. Patients divided into four groups according to status AF. The...
Background:We examined the relationship and combined effect of vascular calcification (VC) left ventricular hypertrophy (LVH) on deaths cardiovascular events (CVEs) in hemodialysis (HD) patients.Methods: Maintenance HD patients (n=341) were included.Echocardiography data plain chest radiographs used to assess LVH aortic arch VC.Results: VC was found 100 (29.3%).LVH more prevalent with compared those without (70% vs. 50.2%,P=0.001).VC independently associated a 2.42-fold increased risk (95%...
This study was designed to evaluate the longitudinal history of cytomegalovirus (CMV) infection and test capacity ganciclovir as effective therapy in CMV-seropositive renal transplant recipients. The CMV viremia detected with pp65 antigenemia assay 153 transplants. recipients were classified having low-grade high-grade infections according severity infection. observed without treatment, randomly assigned ganciclovir-treated untreated groups. clinical course between evaluated. All (n = 62)...