A5034024098- Central Venous Catheters and Hemodialysis
- Dialysis and Renal Disease Management
- Vascular Procedures and Complications
- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Adipose Tissue and Metabolism
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Blood Pressure and Hypertension Studies
- Hepatitis Viruses Studies and Epidemiology
- Genetic and Kidney Cyst Diseases
- Transplantation: Methods and Outcomes
- Vascular anomalies and interventions
- Renal and related cancers
- Hormonal Regulation and Hypertension
- Immune Cell Function and Interaction
- Sirtuins and Resveratrol in Medicine
- Organ Donation and Transplantation
- Hepatitis C virus research
- Lysosomal Storage Disorders Research
- Parathyroid Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Polyomavirus and related diseases
- Organ and Tissue Transplantation Research
- Hepatitis B Virus Studies
Seoul St. Mary's Hospital
2011-2025
Catholic University of Korea
2014-2025
St. Vincent's Hospital
2014-2019
Peroxisome proliferator-activated receptor (PPAR)-α, a lipid-sensing transcriptional factor, serves an important role in lipotoxicity. We evaluated whether fenofibrate has renoprotective effect by ameliorating lipotoxicity the kidney. Eight-week-old male C57BLKS/J db/m control and db/db mice, divided into four groups, received for 12 weeks. In ameliorated albuminuria, mesangial area expansion inflammatory cell infiltration. Fenofibrate inhibited accumulation of intra-renal free fatty acids...
Adiponectin has multiple functions including insulin sensitization, anti-inflammation and antiatherogenesis in various organs. activates 5'-adenosine monophosphate-activated protein kinase (AMPK) peroxisome proliferator-activated receptor (PPAR)α via the adiponectin (AdipoR) 1 2, which are critical for regulating lipids glucose homeostasis controlling oxidative stress. We investigated whether resveratrol can inhibit renal damage type 2 diabetic db/db mice underlying mechanisms of its...
Oxidative stress plays a crucial role in the pathogenesis of diabetic nephropathy (DN). We evaluated whether extracellular superoxide dismutase (EC-SOD) has renoprotective effect through activation adenosine monophosphate-activated protein kinase (AMPK) kidneys.Human recombinant EC-SOD (hEC-SOD) was administered to 8-week-old male C57BLKS/J db/db mice intraperitoneal injection once week for 8 weeks. Renal SOD3 expression suppressed mice, which significantly enhanced by hEC-SOD treatment....
Abstract Objectives To explore the possibility of kidney organoids generated using patient derived human induced pluripotent stem cells (hiPSC) for modeling Fabry disease nephropathy (FDN). Methods First, we hiPSC line peripheral blood mononuclear (PBMCs) from two male FD-patients with different types GLA mutation: a classic type mutation (CMC-Fb-001) and non-classic (CMC-Fb-003) mutation. Second, wild-type (WT) (WTC-11) mutant hiPSCs (CMC-Fb-001 CMC-Fb-003). We then compared...
Intradialytic hypotension (IDH) is a serious complication of hemodialysis (HD) that associated with increased risks cardiovascular morbidity and mortality. However, its accurate prediction remains clinical challenge. The aim this study was to develop deep learning-based artificial intelligence (AI) model predict IDH using pre-dialysis features.Data from 2007 patients 943 220 HD sessions at seven university hospitals were used. performance the learning compared three machine models (logistic...
An arteriovenous fistula or graft is essential for hemodialysis (HD). It involves connecting a high-resistance artery to low-resistance vein, which increases cardiac output (CO). In the early days of HD, patients with end-stage kidney disease (ESKD) were typically younger, and their HD access was located in distal forearm. However, modern era, ESKD are often elderly, many being very elderly (over 80 years old). These have poor vessel quality, making forearm unsuitable. As result, upper arm...
Abstract Background The revised 2023 guidelines from the International Society for Peritoneal Dialysis (ISPD) emphasize salvage methods treating refractory catheter-related infections, or mechanical catheter damage. This approach preserves existing by manipulating only outer cuff above peritoneum, avoiding hemodialysis transfer. We investigated effectiveness of partial replantation technique. Methods In this retrospective single-center study (January 2021 - December 2023), outcomes nine...
The aims of this study were to assess changes in muscle mass and strength according bone mineral density (BMD) after alendronate-calcitriol therapy subsequent common biomarkers for osteoporosis sarcopenia establish a strategy against these coexisting conditions.Thirty-eight women with osteopenia without conditions affecting calcium metabolism, inflammatory cytokines, acute chronic medical conditions, regular endurance exercise completed the study. Appendicular lean BMD measured, relative...
High baseline anti-ABO antibody titer is still an important obstacle for successful ABO-incompatible kidney transplantation (ABO IKT). This study aims to investigate the clinical outcome of ABO IKT in patients with a high comparison low titer. Fourteen who received at our center were classified as high-titer group (≥1:256, n = 8) or low-titer (≤1:128, 6). We used protocol composed rituximab, plasmapheresis, and intravenous immunoglobulin (RTX/PP/IVIG). compared intensity preparation,...
Osmotic demyelination syndrome (ODS) primarily occurs after rapid correction of severe hyponatremia. There are no proven effective therapies for ODS, but we describe the first case showing successful treatment central pontine myelinolysis (CPM) by plasma exchange, which occurred development hypernatremia from intravenous sodium bicarbonate therapy. A 40-year-old woman presented with general weakness, hypokalemia, and metabolic acidosis. The patient was treated oral potassium chloride, along...
The aim of this study was to evaluate whether the Th17 and Treg cell infiltration into allograft tissue is associated with severity dysfunction injury in acute T cell-mediated rejection (ATCMR). Seventy-one tissues biopsy-proven ATCMR were included. biopsy specimens immunostained for FOXP3 IL-17. function assessed at by measuring serum creatinine (Scr) concentration, applying modified diet renal disease (MDRD) formula, which provides estimated glomerular filtration rate (eGFR). calculating...
Abstract Numerous designs for tunneled hemodialysis catheter have been developed in an effort to improve function and survival. In this prospective randomized controlled study, 97 patients were into the palindrome group (PC, n = 47) step‐tip (SC, 50). Demographic characteristics not different between two groups. The effective blood flow rates at pump speeds comparable recirculation was low within acceptable range both types of catheter, adequacy However, when arterial venous lines reversed,...
<b><i>Background:</i></b> Poor vessel quality and limited life expectancy in the elderly may make arteriovenous fistula (AVF) less ideal than graft (AVG) or catheter for vascular access (VA) hemodialysis (HD). <b><i>Methods:</i></b> A total of 946 adult incident HD patients from clinical research center registry end-stage renal disease prospective cohort South Korea were analyzed outcomes with AVF AVG....
Background/Aims Recurrent focal segmental glomerulosclerosis (FSGS) following renal transplantation is relatively common. However, the risk factors and optimal pretransplant treatment preventing recurrence of FSGS remain controversial. Methods We retrospectively reviewed 27 adult transplant recipients with over a period 10 years. first compared possible for between nonrecurrence groups. Then we evaluated effect plasmapheresis (PP; n = 4) PP rituximab (PP + RTX; 5) on after to control...
Background: The aim of this study is to investigate the clinical characteristics and our experience treating patients with IgA nephropathy (IgAN) hepatitis B surface antigen (HBs-IgAN). Methods: From 1996 2011, biopsy-proven IgAN was diagnosed in 477 22 (4.6%) had (HBsAg). Of these, we included 360 who more than 6-month follow-up period, compared renal function decline between HBs-IgAN. Results: patients, were classified as There no differences idiopathic HBs-IgAN (–0.01 vs. –0.17 mL/min per...
Chronic kidney disease (CKD) is a significant risk factor for contrast induced acute injury (CI-AKI) after percutaneous coronary intervention (PCI). This study included 1592 CKD patients extracted from prospective multicenter, all comer-based registry of undergoing PCI. In multivariate logistic analysis CI-AKI development, linear trend was observed between the quartiles HDL-C (quartile 1 vs. 2: odds ratio [OR], 0.716; 95% confidence interval [CI], 0.421-1.219; quartile 3: OR, 0.534; CI,...
Invasive aspergillosis (IA), generally considered an opportunistic infection in immunocompromised hosts, is associated with high morbidity and mortality. IA commonly occurs the respiratory tract isolated reports of nasal sinuses, central nervous system, skin, liver, urinary tract. Extra-pulmonary usually observed disseminated disease. To date, there are a few studies regarding primary gastrointestinal (GI) hosts. Only cases GI non-immunocompromised hosts have been reported; these, almost all...
To increase the rate of arteriovenous fistula (AVF) use, assisted procedures for immature AVF have been strenuously performed. However, this is controversial in that an matured by these may require more frequent intervention to maintain its patency, and decreased long-term patency.Eighty four AVFs were with maturation 266 spontaneously without intervention, created between November 2009 March 2013 from hemodialysis (HD) vascular access (VA) cohort, compared retrospectively we also...
Background/Aims Chronic hepatitis B infection is a common cause of secondary membranous nephropathy (MN) in endemic areas. Lamivudine treatment improves renal outcome patients with virus-associated MN (HBV-MN), but prolonged use leads to the emergence lamivudine-resistant variants. We describe our experience treating and other strains HBV-MN new antiviral drugs. Methods Of 89 biopsied diagnosed from 1996 2011, 10 positive for surface antigen were recruited this study. investigated clinical...
A 61-year-old man presented with lower extremity paralysis and severe hypokalemia. His thyroid function test showed thyrotoxicosis. Despite attempts to correct his hypokalemia, he developed pulseless polymorphic ventricular tachycardia two hours later. He was successfully resuscitated after defibrillation. We performed continuous venovenous hemodiafiltration for 10 days due acute kidney injury rhabdomyolysis. observed life-threatening requiring urgent defibrillation, as well rhabdomyolysis...
Renal dysfunction after allogeneic hematopoietic stem cell transplantation (HSCT) has been increasingly reported. However, there are few reports on the changes of estimated glomerular filtration rate (eGFR) in long-term survivors HSCT.The medical records at Seoul St. Mary's Hospital Korea were reviewed to identify all adult (> 18-years-of-age) patients who had undergone high-dose chemotherapy and HSCT between January 2001 December 2005. Among these patients, those with < 5 years follow-up...