A5014315273- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Organ and Tissue Transplantation Research
- Liver Disease and Transplantation
- Neurological Complications and Syndromes
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Aortic aneurysm repair treatments
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Palliative Care and End-of-Life Issues
- Renal Diseases and Glomerulopathies
- Cardiac Ischemia and Reperfusion
- Vascular anomalies and interventions
- Grief, Bereavement, and Mental Health
- Clinical Nutrition and Gastroenterology
- Peripheral Artery Disease Management
- Acute Kidney Injury Research
- Blood groups and transfusion
- Pneumocystis jirovecii pneumonia detection and treatment
- Aortic Disease and Treatment Approaches
Korea International Cooperation Agency
2021-2024
Catholic University of Korea
2012-2021
Bioscience Research
2021
Weatherford College
2021
Yeouido St. Mary's Hospital
2017-2020
Creative Commons
2019
Inje University Busan Paik Hospital
2019
Seoul St. Mary's Hospital
2008-2017
Singapore Maritime Institute
2016
Inje University
2014
The postsynaptic density (PSD) is a specialization of the submembranous cytoskeleton that visible in electron microscope on cytoplasmic face membrane. A subcellular fraction enriched structures with morphology PSDs contains signal-transduction molecules thought to regulate receptor localization and function central nervous system. We have purified prominent tyrosine-phosphorylated glycoprotein apparent molecular mass 180 kDa, termed PSD-gp180, highly rat forebrain PSD fraction. sequences...
Liver resection (LR) and liver transplantation (LT) are considered the only two potentially curative treatments for hepatocellular carcinoma (HCC). Recently, there has been an intense debate as to whether LR or LT is optimal initial treatment patients with Child A B cirrhosis. The aim of this study was compare results in HCC cirrhosis a single center over 10-year period.Seventy-eight were treated 130 LR. We evaluated patient characteristics, short-term such hospital stay, postoperative...
We report here our 10-year experience of a biopsy performed at day 14 after transplantation in 304 patients with stable graft function. The factors that may have influenced subclinical rejection were analyzed according to histology. incidence was 13.2%. Addition mycophenolate mofetile (MMF) as primary immunosuppressant significantly decreased the compared without such treatment (odds ratio, 0.23; p < 0.05). On other hand, HLA-DR antigen mismatch 2.39) and unrelated donor 2.10) also...
Knowledge of kidney size is important for clinical assessment renal disease. However, there are few studies on methods assessing size. The purpose this study was to determine the usefulness body index and radiological measurements prediction size.One hundred twenty five donors were enrolled. sizes donor kidneys obtained after nephrectomies transplantations documented correlation coefficient between length calculated. Kidney estimated from distance first third lumbar vertebrae (L1-3),...
Infectious complications following living-donor liver transplantation (LDLT) remain a major cause of morbidity and mortality. We analyzed the frequency type infectious according to post-transplantation period, their risk factors with regard mortality.We retrospectively 208 subjects who had undergone LDLT during 9-year period.The rate infection was 1.69 per patient study period. The predominant infections were intra-abdominal (37.6%), primary bacteremia (17.4%), pneumonia (14.5%). Within...
Purpose: Bacteremia is a major infectious complication associated with mortality in liver transplant recipients.The causative organisms and clinical courses differ between medical centers due to variations regional bacterial epidemiology posttransplant care.Further, living donors Korea contribute 83% of transplants, individualized data are required improve survival rates.Patients Methods: We retrospectively analyzed 104 subjects who had undergone living-donor from 2005 2007.Results: Among...
Background. Ischemia/reperfusion (I/R) injury in the early posttransplant period is closely associated with delayed recovery of graft function, increased acute rejection, and late allograft dysfunction. Pharmacological preconditioning low-dose cyclosporine (CsA) or FK506 was performed to induce ischemic tolerance rat kidney I/R injury. Methods. Low-dose CsA (3 mg/kg, administered i.v.) (0.3 mg/kg were used Sprague-Dawley rats, induction heat shock protein (hsp) 70 by evaluated overtime. Rats...
With the development of single antigen beads assay, role donor specific alloantibody (DSA) against human leukocyte antigens in kidney transplantation (KT) has been highlighted. This study aimed to investigate clinical significance DQ-DSA detected at renal allograft biopsy. We evaluated 263 KT recipients who underwent biopsy and DSA detection same time. Among them, 155 patients were nonsensitized before selected de-novo DQ-DSA. Both total subgroup was categorized into 4 groups each according...
High baseline anti-ABO antibody titer is still an important obstacle for successful ABO-incompatible kidney transplantation (ABO IKT). This study aims to investigate the clinical outcome of ABO IKT in patients with a high comparison low titer. Fourteen who received at our center were classified as high-titer group (≥1:256, n = 8) or low-titer (≤1:128, 6). We used protocol composed rituximab, plasmapheresis, and intravenous immunoglobulin (RTX/PP/IVIG). compared intensity preparation,...
Background. The toll-like receptor (TLR) is stimulated by not only pathogen-associated molecular patterns but also endogenous TLR ligands provided injured cells. influence of cyclosporine A (CsA)-induced renal injury on expression and subsequent signaling pathway was evaluated. Methods. Induction chronic CsA nephropathy made administering (15 mg/kg/day) for 28 days in rats. TLR2 TLR4 mRNA protein expression, TLR-signaling (MYD88, NF-κB AP-1), putative ligand (heat shock 70 [HSP70]),...
<i>Background:</i> Evidence suggests that recombinant human erythropoietin (rHuEPO) protects neurons and cardiomyocytes from acute insults. We investigated the protective effect of rHuEPO on cyclosporine (CsA)-induced renal injury. <i>Methods:</i> CsA (15 mg/kg/day) was given to rats for 1 or 4 weeks, concurrently administered at a dose 100 units/kg (thrice weekly). Effects CsA-induced injury were evaluated with tubulointerstitial fibrosis (TIF) score, macrophage...
Abstract Introduction We investigated the effect of combined use rituximab ( RTX ) and plasmapheresis PP pre‐transplant on post‐transplant infection. Methods A total 196 patients undergoing living‐donor kidney transplantation at Seoul St. Mary's Hospital, all whom underwent basiliximab induction therapy, were included in study. They divided into 3 groups: / /intravenous immune globulin IVIG (the RPI group; n = 53), monotherapy 14), control CONT 129). compared infections groups. Results The...
<b><i>Background/AIMS:</i></b> We investigated the impact of baseline anti-A/B antibody titer on clinical outcome in ABO-incompatible kidney transplantation (IKT). <b><i>Methods:</i></b> included 183 patients who had undergone KT (40 ABO IKT and 143 ABO-compatible KT). Eight with a ≥1:512 were assigned to high-titer group 32 ≤1:256 low-titer group. Patients underwent used as control compared outcomes three groups....
Background. The signaling pathways of mitogen-activated protein kinases (MAPKs) are important molecular components responsible for ischemia/reperfusion (I/R) injury in the kidneys. Preconditioning with cyclosporine A (CsA) or FK506 reduces subsequent I/R injury. We studied effect preconditioning CsA on MAPK expression ischemic rat Methods. Two separate studies were performed using Sprague-Dawley rats. First, (extracellular signal-regulated kinase [ERK], jun N-terminal [JNK], p38) expressions...
Acute kidney injury (AKI) is frequently detected in deceased donors (DDs), and it could be associated with adverse clinical outcomes corresponding transplant recipients (KTRs). In this regard, we sought to identify which criteria better between the KDIGO AKIN for diagnosis of AKI DDs prediction after transplantation (KT).Two hundred eighty-five cases donor (DDKT) were included. We divided them into three groups; non-AKI by both group (n = 120), only 61), 104) according using 205 DDs....