A5101626383- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Organ Transplantation Techniques and Outcomes
- Blood Pressure and Hypertension Studies
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Hemodynamic Monitoring and Therapy
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Diabetes Treatment and Management
- Liver Disease and Transplantation
- Parathyroid Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Climate Change and Health Impacts
- Birth, Development, and Health
- Health Systems, Economic Evaluations, Quality of Life
- Renal function and acid-base balance
- T-cell and B-cell Immunology
Seoul National University Hospital
2016-2025
Seoul National University
2016-2025
New Generation University College
2013-2025
Korea Center for Disease Control and Prevention
2013-2023
Dongguk University Ilsan Hospital
2023
Inje University Seoul Paik Hospital
2023
Samsung Medical Center
2023
National University College
2001-2022
Kidney Research UK
2009-2022
Government of the Republic of Korea
2022
Severe hyperkalemia, with potassium (K+) levels ≥ 6.5 mEq/L, is a potentially life-threatening electrolyte imbalance. For prompt and effective treatment, it important to know its risk factors, clinical manifestations, predictors of mortality.An observational cohort study was performed at 2 medical centers. A total 923 consecutive Korean patients were analyzed. All 19 years age or older hospitalized severe hyperkalemia between August 2007 July 2010; the diagnosis made either time admission...
The data were presented in abstract form at the 45th meeting of American Society Nephrology, October 30-November 04 2012, San Diego, CA, USA. Circulating autoantibodies against M-type phospholipase A2 receptor (PLA2R) are important pathogenic antibodies idiopathic membranous nephropathy (MN) adults. However, previous studies on clinical impact anti-PLA2R demonstrated several limitations, including insufficient numbers study subjects and different time points methods for antibody measurement....
Abstract Accurate prediction of graft survival after kidney transplant is limited by the complexity and heterogeneity risk factors influencing allograft survival. In this study, we applied machine learning methods, in combination with statistics, to build new models that included immunological factors, as well known recipient donor variables. Graft was estimated from a retrospective analysis data multicenter cohort 3,117 recipients. We evaluated predictive power ensemble algorithms (survival...
Significance Statement Poor sleep is known to be related kidney function impairment. Using the UK Biobank cohort, including individuals self-reporting regular patterns of short, intermediate, or long duration, authors found that short duration was associated with higher prevalence CKD. In genetic analysis, risk score for but not significantly a CKD stages 3–5, suggesting causal effects on Two-sample Mendelian randomization using independent meta-analysis results from CKDGen Consortium...
Metformin is the first pharmacological option for treating type 2 diabetes. However, use of this drug not recommended in individuals with impaired kidney function because perceived risk lactic acidosis. We aimed to assess efficacy and safety metformin patients diabetic disease (DKD).We conducted a retrospective observational cohort study 10,426 DKD from two tertiary hospitals. The primary outcomes were all-cause mortality end-stage renal (ESRD) progression. secondary outcome was...
Abstract This study aimed to compare health-related quality of life (HRQOL) over time in patients initiating hemodialysis (HD) or peritoneal dialysis (PD). A total 989 incident starting HD PD were included from a prospective nationwide cohort study. HRQOL was assessed 3, 12, and 24 months after the start dialysis. The scores questionnaires adjusted for clinical socioeconomic parameters. three on showed better eight end-stage renal disease (ESRD), physical component summary one mental domains...
Abstract Background Previous scoring models such as the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) Sequential Organ Failure (SOFA) systems do not adequately predict mortality of patients undergoing continuous renal replacement therapy (CRRT) for severe acute kidney injury. Accordingly, present study applies machine learning algorithms to improve prediction accuracy this patient subset. Methods We randomly divided a total 1571 adult who started CRRT injury into...
Researchers have suggested models to predict the risk of postoperative AKI (PO-AKI), but an externally validated index that can be practically implemented before patients undergo noncardiac surgery is needed.We performed a retrospective observational study without preexisting renal failure who underwent operation (≥1 hour) at two tertiary hospitals in Korea. We fitted proportional odds model for ordinal outcome consisting three categories: critical (defined as Kidney Disease Improving Global...
Population-scale evidence for the association between dynamic changes in metabolic syndrome (MetS) status and alterations risk major adverse cardiovascular events (MACE) is lacking.To investigate whether recovery from or development of MetS a population associated with an altered MACE.Nationwide cohort study.An analysis based on National Health Insurance Database Korea.A total 27 161 051 persons who received national health screenings 2009 to 2014 were screened. Those history MACE excluded....
The aim of this study was to investigate the causal effects between atrial fibrillation (AF) and kidney function.We performed a bidirectional summary-level Mendelian randomization (MR) analysis implementing results from large-scale genome-wide association for estimated glomerular filtration rate (eGFR) by CKDGen (N = 765 348) AF 588 190) identify genetic instruments. inverse variance weighted method main MR used. For replication, an allele score-based individual-level data within UK Biobank...
Intradialytic hypotension has high clinical significance. However, predicting it using conventional statistical models may be difficult because several factors have interactive and complex effects on the risk. Herein, we applied a deep learning model (recurrent neural network) to predict risk of intradialytic timestamp-bearing dataset.We obtained 261,647 hemodialysis sessions with 1,600,531 independent timestamps (i.e., time-varying vital signs) randomly divided them into training (70%),...
Background. The efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT2i) have not been investigated in kidney transplant recipients (KTRs) with diabetes. We evaluated the impact SGLT2i a multicenter cohort diabetic KTRs. Methods. A total 2083 KTRs diabetes were enrolled from 6 centers Korea. Among them, 226 (10.8%) patients prescribed for >90 d. primary outcome was composite all-cause mortality, death-censored graft failure (DCGF), serum creatinine doubling. An acute dip...
The roles of neutrophils in renal inflammation are currently unclear. On examining these cells the unilateral ureteral obstruction murine model chronic kidney disease, we found that injured bore a large and rapidly expanding population expressed eosinophil marker Siglec-F. We first verified were neutrophils. Siglec-F+ recently detected several studies other disease contexts. then showed a) derived from conventional vasculature by TGF-β1 GM-CSF; b) they differed their parent more frequent...
Intestinal microbiota and their metabolites affect systemic inflammation kidney disease outcomes. Here, we investigated the key associated with acute injury (AKI)-to chronic (CKD) transition effect of antibiotic-induced depletion (AIMD) on this transition. In 61 patients AKI, 59 plasma were assessed to determine risk AKI-to-CKD An murine model was established four weeks after unilateral ischemia-reperfusion (IRI) effects AIMD gut microbiome, metabolites, pathological responses related CKD...
Abstract It has been suggested that the inflammatory cytokine IL-15 plays an important role in development of several autoimmune diseases, including rheumatoid arthritis. We have generated a unique lytic and antagonistic mutant/Fcγ2a fusion protein (CRB-15) targets IL-15R. In present study we examined effects targeting IL-15R on prevention treatment collagen-induced arthritis (CIA) mice probed possible mechanisms action this protein. Upon immunization with type II collagen, DBA/1 develop...
Race and ethnicity are influential in estimating glomerular filtration rate (GFR).We aimed to find the Korean coefficients for Modification of Diet Renal Disease (MDRD) study equations obtain novel proper estimation equations.Reference GFR was measured by systemic inulin clearance.Serum creatinine (SCr) values were alkaline picrate Jaffé kinetic method, then, recalibrated CX3 analyzer isotope dilution mass spectrometry (IDMS).The 4 6 variable MDRD IDMS based on SCr 0.73989/0.74254and...
Several studies have suggested a potential effect of serum bilirubin as an antioxidant and cytoprotectant factor. For the results presented here, we evaluated correlation between diabetes mellitus (DM) or chronic kidney disease originated from DM (DMCKD) in Korean population. We used cross-sectional, population-based design to examine 93,909 subjects (aged 18-96 years, 53.0% male). The trend P values odds ratios for being DMCKD was calculated using patients separated into five groups based...
Pulmonary fibrosis is a potentially life-threatening disease that may be caused by overt or asymptomatic inflammatory responses. However, the precise mechanisms which tissue injury translated into inflammation and consequent remain to established. Here, we show in lung model, bleomycin induced secretion of IL-6 epithelial cells transglutaminase 2 (TG2)–dependent manner. This response represents key step differentiation IL-17–producing T subsequent amplification lung. The essential role...