A5086334713- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Dialysis and Renal Disease Management
- Nephrotoxicity and Medicinal Plants
- Pharmacological Effects and Toxicity Studies
- Renal Diseases and Glomerulopathies
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Renal and Vascular Pathologies
- Neurological and metabolic disorders
- Electrolyte and hormonal disorders
- Venous Thromboembolism Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Potassium and Related Disorders
- Pediatric Urology and Nephrology Studies
- Biomedical Research and Pathophysiology
- Central Venous Catheters and Hemodialysis
- Magnesium in Health and Disease
- Vasculitis and related conditions
- Erythropoietin and Anemia Treatment
- Medication Adherence and Compliance
- Neurological Complications and Syndromes
- Atherosclerosis and Cardiovascular Diseases
University of Nis
2015-2024
Klinički centar Niš
2017-2024
Deleted Institution
2017-2024
Amrita Institute of Medical Sciences and Research Centre
2017
General University Hospital in Prague
2017
Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence BEN on Peninsula assumed result consumption clematitis L. seeds coharvested with crops. Here, we show that AAs are long-lived soil contaminants enter wheat maize by root uptake strong pH dependence. Soil crops Serbian farms in areas for A. were found be extensively contaminated AAs,...
Abstract Occurrence of urosepsis is not uncommon following urinary tract infections (UTI). However, there a lack evidence explaining the risk factors predisposing to in patients with chronic kidney disease (CKD). This retrospective study was undertaken evaluate incidence and possible for among hospitalized UTI cohort CKD patients. Patients were divided into group non-urosepsis group. Of 489 UTI, 70 (14.3%) acquired urosepsis. Stepwise multivariate logistic regression demonstrated that...
Aim. The aim of the present study was to investigate value urine cell glycoprotein 1 (PC-1), aminopeptidase N (APN), N-acetyl-β-D-glucosaminidase (NAGA), and dipeptidylpeptidase IV (DPP IV) in evaluation tubular damage patients with primary glomerulonephritis, diabetic nephropathy, lupus nephritis. Subjects Methods. PC-1, APN, NAGA, DPP activities were determined serum, urine, lymphocytes 178 subjects, including 10 membranous 38 IgA 29 nephritis, 51 50 control subjects. Results. Urinary PC-1...
Introduction. In spite of the growing number reports on study anti-nucleosome and anti-C1q antibodies, there are still controversies their significance as disease activity markers in patients with systemic lupus erythematosus (SLE) use everyday clinical practice. Objective. Our aim was to assess presence anti-dsDNA, antibodies SLE patients, well establish sensitivity, specificity, positive negative predictive value, correlation nephritis activity. Methods. The enrolled 85 aged 45.3?9.7 years...
<b><i>Objectives:</i></b> To assess the degree of immunosuppressive medication adherence in kidney transplant patients (KTPs) and to determine if there is a difference rate tacrolimus (Tac), cyclosporine (CsA) sirolimus (Sir). <b><i>Subjects Methods:</i></b> From total 63 KTPs treated at Clinic Nephrology, Clinical Centre Niš, Serbia, 60 participated study by responding questionnaires. They were divided into group (n = 43) nonadherence 17)...
Oxidative stress (OS) frequently contributes to the development of acute kidney injury (AKI). Iron can promote oxidative and tissue by catalyzing free reactive oxygen species (ROS) generation increasing steady-state concentration these potent oxidants. The anticipated role ferritin is protect from OS sequestering iron limiting its involvement in reactions that generate ROS. In this prospective study, we aimed investigate association between serum levels function recovery among patients with...
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Glucocorticoids and classic immunosuppressive drugs can improve disease activity in primary glomerulonephritis (GN). However, these have serious toxicity patients frequently experience inadequate response or relapse, so there is a need for alternative agents. This multicenter uncontrolled study analyzed the efficacy safety of mycophenolate mofetil (MMF) high-risk with GN.A total 51 biopsy-proven membranous (n = 12), membranoproliferative 15), mesangioproliferative 10), focal segmental...
Background and objectives: Metabolic syndrome (MetS) is a cluster of risk factors, such as abdominal obesity, insulin resistance, dyslipidemia hypertension, that together increase the cardiovascular disease. Chronic hemodialysis (HD) patients have multiple comorbidities many metabolic disorders, causing frequent occurrence syndrome. The goal this study was to assess prevalence MetS in HD patients, its association with all-cause (CV) mortality. Patients methods: A total 138 were included...
Background and Objectives: Given the fact that galectin-3 has a predictive significance on development of myocardial dysfunction after acute infarction, aim our study was to examine potential factors could be important for dynamics concentration this biomarker in early postinfarction period. Materials Methods: This included 89 patients with diagnosis stable angina pectoris (SAP) or first non-ST elevation (NSTEMI) ST-elevation (STEMI) who underwent percutaneous coronary intervention (PCI)....
Abstract A 39-year-old female presented to the nephrology clinic emergency department with a complaint of muscle weakness and stomach pain. detailed personal history revealed ingestion 50–100 g herbal products which contained licorice, every day for 8 weeks treat sterility. The product was studied determined contain ‘licorice’ containing glycyrrhizic acid. Licorice (a plant contains acid) induced hypokalemia usually has mild progression. However, it may cause critical failure in physical...
BACKGROUND: Organ damage in patients with systemic lupus erythematosus (SLE) occurs as a consequence of the disease itself, therapy applied and accompanying conditions complications. predicts further organ is associated an increased risk death. OBJECTIVE: This study aimed to assess degree irreversible changes SLE patients, using Systemic Lupus International Collaborating Clinics/American College Rheumatology (SLICC/ACR) index (SDI); establish correlations between activity, quality life,...
<i>Background/Aims:</i> Mycophenolate mofetil (MMF) has been increasingly used for the treatment of lupus nephritis (LN). The aim this study was to examine efficacy and safety MMF with low doses corticosteroids as maintenance therapy in patients LN. <i>Methods:</i> covered 35 patients, most them proliferative types LN (5 WHO class III, 26 IV), while 1 had V 3 VI nephritis. administered dose 1.5–2 g/24 h prednisone at 10–20 mg/day. effects were followed over a 12-month...
We present a case which reports the occurrence of psychotic disorders after metronidazole and levofloxacin therapy in chronic kidney patient while being treated for enterocolitis urinary infection. A 48-year-old female was admitted to hospital placement peritoneal dialysis catheter due indicated dialysis. During admission, symptoms infection had occurred, so were introduced into therapy, respectively. After 4 days 3 became confused, disoriented, with signs delirium. Since diagnosis...
Background: Tacrolimus (Tac) is characterized by large between- and within-patient (IPV) variability in pharmacokinetics exposure. Aim: This study aimed to assess validate the effect of Tac IPV trough concentration-to-dose ratio (C0/D) over 6-12 months on reduced estimated glomerular filtration rate (eGFR) values late period after kidney transplantation (Tx), applying Monte Carlo (MC) simulation. Methods: The previously published linear regression was basis for MC simulation, performed...
Abstract Background Patients with end-stage renal disease (ESRD) receiving hemodialysis (HD) often experience bleeding. However, mechanisms behind this bleeding tendency are incompletely understood but may involve platelet dysfunction. We, therefore, studied platelet-dependent thrombus formation in flowing whole blood inside a microchip coated collagen, and its association circulating von Willebrand factor (VWF). Methods Blood samples were obtained 22 patients before after HD. The area under...
The study aimed to estimate and compare the prevalence type of potentially inappropriate medications (PIMs) potential prescribing omissions (PPOs) between STOPP/START original (v1) updated version (v2) among older patients in various settings, as well associated factors. included 440 attending a community pharmacy, 200 outpatients 140 nursing home users. An increase STOPP v2 (57.9%) compared v1 (56.2%) was not statistically significant total sample within each setting (p>0.05). A decrease...
Background and Objectives: It is well known that alterations in microvascular structure function contribute to the development of ocular, renal, cardiovascular diseases. Accordingly, presence fundus vascular changes patients suffering from chronic kidney disease (CKD) Balkan endemic nephropathy (BEN) may provide information prognostic value regarding progression renal disease. This study aimed examine associations between clinical characteristics retinal optical coherence tomography...