A5047885891- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Blood properties and coagulation
- Pharmacology and Obesity Treatment
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Healthcare cost, quality, practices
- Clinical practice guidelines implementation
- Cardiac Imaging and Diagnostics
- Lung Cancer Research Studies
- Cardiac Health and Mental Health
- Nitric Oxide and Endothelin Effects
- Cardiac Arrhythmias and Treatments
- Bariatric Surgery and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Meta-analysis and systematic reviews
- Acute Myocardial Infarction Research
- Erythropoietin and Anemia Treatment
- Chronic Kidney Disease and Diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Health and Disease Prevention
Karolinska Institutet
2021-2025
Danderyds sjukhus
2023-2024
Karolinska University Hospital
2007
Abstract Context Bariatric surgery is associated with reduced risk of cardiometabolic disease in obesity and type 2 diabetes (T2D). The mechanisms are not fully understood, but improvement endothelial dysfunction has been implicated. Objective To assess biomarkers before after surgery. Design Prospective cohort study 2-year follow-up. Setting Single center Stockholm, Sweden. Patients Adults undergoing bariatric surgery, 28 33 without T2D. Intervention Roux-en-y gastric bypass preceded by...
Summary Stress may counteract responses to antiplatelet drug treatment. We investigated if adding clopidogrel aspirin treatment could attenutate stress-induced platelet activation and myocardial ischemia in patients with coronary artery disease (CAD). Thirty-one male documented CAD-treated (75–160 mg daily) were randomized co-treatment (n=16) or placebo (n=15). A symptom-limited exercise test 48-hour (h) Holter monitoring performed before after two weeks of double-blind Platelet function was...
The increased risk of vascular complications in type 1 diabetes may part be explained by changes haemostatic function. In the present study, we investigated fibrin clot properties patients with relation to sex and microvascular complications. study included 236 (107 women) aged between 20-70 years without any history cardiovascular disease. Fibrin properties, assessed determination permeability coefficient (Ks) turbidimetric clotting lysis assays, did not differ men women. Compared men,...
Inflammation is a hallmark of cancer, and the role neutrophils neutrophil extracellular traps (NETs) in cancer cancer-associated thrombosis has attracted lot interest. The NET-specific marker H3Cit been found to be elevated plasma patients with malignancies, suggesting NETs markers as novel biomarkers. This study aimed determine levels (H3Cit dsDNA) women adnexal masses.Peripheral blood samples were obtained from 199 admitted for primary surgery masses. Patients grouped according tumor type...
There are important pharmacological differences between direct oral anticoagulants (DOAC) and a deeper knowledge of how they influence different aspects hemostasis in patients on treatment is desirable.
Abstract Background Patients with end-stage renal disease (ESRD) receiving hemodialysis (HD) often experience bleeding. However, mechanisms behind this bleeding tendency are incompletely understood but may involve platelet dysfunction. We, therefore, studied platelet-dependent thrombus formation in flowing whole blood inside a microchip coated collagen, and its association circulating von Willebrand factor (VWF). Methods Blood samples were obtained 22 patients before after HD. The area under...
Abstract Background End-stage renal disease patients receiving hemodialysis (HD) are at increased risk of both bleeding and thrombotic complications. There are, however, few tools to help clinicians with stratification the individual patient. Aims Method To study if Total Thrombus-formation Analysis System (T-TAS01), which measures thrombus formation in flowing whole blood inside a microchip [1], can be used predict complications on HD. Odds-ratios were calculated using median split...
Abstract BACKGROUND AND AIMS Patients with end-stage renal disease (ESRD) receiving haemodialysis (HD) often experience bleeding. However, mechanisms behind this bleeding tendency are incompletely understood but may involve platelet dysfunction. We therefore studied platelet-dependent thrombus formation in flowing whole blood inside a microchip coated collagen, and its association circulating von Willebrand factor (VWF). METHOD Blood samples were obtained 22 patients before after HD. The...