A5023668588- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Pancreatic function and diabetes
- Acute Kidney Injury Research
- Renal and related cancers
- Diabetes Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Genetic and Kidney Cyst Diseases
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Dialysis and Renal Disease Management
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Organ Transplantation Techniques and Outcomes
- Parathyroid Disorders and Treatments
- Renal and Vascular Pathologies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Complications and Syndromes
- Biomedical Research and Pathophysiology
- Drug-Induced Adverse Reactions
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Atrial Fibrillation Management and Outcomes
- Gout, Hyperuricemia, Uric Acid
Inje University Ilsan Paik Hospital
2018-2024
Seoul National University
2016-2021
Seoul National University Hospital
2014-2017
SMK University of Applied Social Sciences
2016
Interleukin-6 (IL6) is an important regulator of cellular hypertrophy through the gp130/Janus kinase 2 (JAK2)/signal transducer and activator transcription 3 (STAT3) pathway. We tested hypothesis that IL6 its downstream gp130/JAK2/STAT3 pathway participated in high glucose (HG)-induced podocyte hypertrophy.IL6 levels media lysates podocytes were measured by enzyme-linked immunosorbent assay. Western blots performed to determine protein expression among cultured with normal (NG), NG +...
Despite that clinical trials have been examining the safety profile of coronavirus disease 2019 (COVID-19) vaccines, there are concerns about long-term side effects as number vaccinations increases. Herein, we report a case new-onset renal-limited anti-myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis after booster vaccination with mRNA 1273 (Moderna) vaccine. A 72-year-old woman no specific past history, and who had normal renal function, developed...
The role of hyperuricemia in disease progression autosomal dominant polycystic kidney (ADPKD) has not been defined well. We investigated the association serum uric acid (sUA) with renal function and effect hypouricemic treatment on rate decline. This is a single-center, retrospective, observational cohort study. A total 365 patients ADPKD who had estimated glomerular filtration (eGFR) ≥ 15 mL/min/1.73 m2 were followed up for > 1 year included our analysis. Hyperuricemia was by sUA level 7.0...
Continuous renal replacement therapy (CRRT) is an important treatment modality for severe acute kidney injury. As such, the epidemiology of CRRT in Korea needs further investigation.We conducted a nationwide, population-based study analyzing claims data from National Health Insurance Service Korea. All index intensive care unit admission cases government-designated tertiary referral hospitals 2005 to 2016 were included. Patients with history or who under 20 years old not considered. In...
We aimed to determine the metabolomic profile of kidney cells under high glucose conditions and following sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment. Targeted metabolomics using Absolute IDQ-p180 kit was applied quantify metabolites in stimulated with (25 50 mM) treated SGLT2 inhibitor, dapagliflozin (2 µM). Primary cultured human tubular epithelial podocytes were used identify The levels asparagine, PC ae C34:1, C36:2 elevated mM significantly decreased after µM level aa...
Conflicting data have been reported on the clinical significance of contrast-induced nephropathy after CT scan (CT-CIN). In addition, epidemiologic characteristics and outcomes CT-CIN following proper prophylactic intervention remain elusive. We examined incidence, risk factors, in stable chronic kidney disease (CKD) patients using collected from our outpatient prophylaxis program conducted between 2007 2014. The recruited with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73...
Based on the fact that B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) have regulatory role in B cell biology, excessive levels of these cytokines can promote autoimmune pathogenesis. However, expression implication remain unresolved cases membranous nephropathy (MN).The plasma BAFF primary MN patients were higher than those healthy controls but lower secondary patients, whereas APRIL similar between controls. The relapse cases, who did not experience remission...
Abstract Background End-stage renal disease yields susceptibility to both ischemia and bleeding. The optimal duration of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation is not established in dialysis patients, who are usually excluded from randomized studies. Since recent studies implied the benefits prolonged DAPT &gt;12 months chronic kidney disease, we investigated effectiveness safety patients with higher cardiovascular risks. Methods In this nationwide...
High glucose-mediated tubular injury contributes to the development and progression of diabetic nephropathy through renal tubulointerstitial fibrosis. V-set immunoglobulin-domain-containing 4 (VSIG4), a B7 family-related protein, is complement receptor. Although role epithelial–mesenchymal transition (EMT) has been reported in several diseases, little known about its relationship with VSIG4 under conditions. This study aimed investigate human tubule cells stimulated by high glucose (HG, 55...
Key Points As a biomarker, urinary metabolites could bridge the gap between genetic abnormalities and phenotypes of diseases. We found that levels betaine, choline, fumarate, citrate, glucose were significantly correlated with kidney function predict outcomes, providing prognostic biomarkers in CKD. Background Because CKD is caused by environmental factors, biomarker development through metabolomic analysis, which reflects gene-derived downstream effects host adaptation to environment,...
An increasing amount of evidence has demonstrated an association between increase in the level tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) progression. We aimed to evaluate if pre-transplant serum TNFSF13 is predictive IgAN recurrence after kidney transplantation.
Given the cardiovascular risk of nonsteroidal anti-inflammatory drugs (NSAIDs), it is essential to identify relationship between NSAIDs and outcomes in dialysis patients who have elevated risk.A case-crossover study was conducted assess association with major adverse cardiac cerebrovascular events (MACCEs) mortality using Korean Health Insurance dataset. The case period defined as 1-30 days prior event date control periods were 61-90 91-120 date.There 3433 8524 incident experienced MACCEs...
Kimura disease (KD) is an eosinophilic, granulomatous, benign, chronic inflammatory with unknown etiology. A 33-year-old woman visited our hospital because of a palpable, left subclavian mass, scapulo-anterior pseudoaneurysm, and nephrotic syndrome. Her lymph node biopsy examination result was consistent KD, results renal indicated secondary membranous nephropathy. After histological confirmed nephropathy, treatment prednisolone cyclosporine initiated, which maintained for over 1 year....
Visit-to-visit systolic blood pressure variability (VTV-SBPV) is correlated with cardiovascular complications. However, it still remains unclear whether VTV-SBPV related to outcomes in patients peritoneal dialysis (PD), who often manifest hypertension. We, therefore, evaluated the association of all-cause mortality, complications, or loss residual renal function (RRF) that a powerful predictor mortality and morbidity PD patients. We retrospectively reviewed medical records for undergoing...
Background/Aims We analyzed chronological changes in hemoglobin according to renal function over a 5-year follow-up period. Methods enrolled 5,266 adults with glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m2 at an initial examination routine health check-up; was conducted 5 years later. categorized the subjects GFR ratio (groups 1, 2, and 3, defined as GFRratio 1.00, 0.75 0.99, < 0.75, respectively). Results The mean level of 74 higher than those 75 89 or 90 (all p 0.001). Among females...
Contrast-induced acute kidney injury (CI-AKI) is one of the most common causes iatrogenic and, therefore, its prevention an important issue. However, whether administration 0.9% saline optimal prophylaxis method remains uncertain due to supra-physiologic chloride component. In particular, recent studies suggest that chloride-restricted solutions showed superiority over in several clinical settings. The investigators designed a multicenter randomized controlled trial compare efficacy balanced...
case demonstrates that Xp11.2 translocation RCC should be considered in the differential diagnosis of renal cystic masses younger ADPKD patients without advanced CKD.
Neuroleptic malignant syndrome is a rare, but potentially life-threatening adverse event associated with the use of neuroleptic agents. We describe case 47-year-old schizophrenic woman who was treated clozapine for years. The patient developed acute renal failure pulmonary edema, and underwent mechanical ventilation hemodialysis.
Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia because hypersecretion renin. We present case 29-year-old female patient with reninoma concomitant variant angina. The had uncontrolled elevated plasma renin activity aldosterone levels. Imaging studies revealed mass in left kidney, which was further confirmed as renin-producing lesion via selective venous catheterization. During evaluation, acute-onset chest pain diagnosed angina after...
The incidence of fractures is much higher in patients with chronic kidney disease, especially those on hemodialysis (HD). Denosumab known to treat osteoporosis. However, no exact guideline exists for treatment denosumab patients, diabetes. This study analyzed the effect HD or without diabetes.Dual-energy X-ray absorptiometry was performed 89 patients: 42 were diagnosed 33 treated denosumab. An observational retrospective analysis conducted 25 whose follow-up biomarkers measured at 6 months...