A5079910160- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Speech Recognition and Synthesis
- Education and Learning Interventions
- Renal Transplantation Outcomes and Treatments
- Phonetics and Phonology Research
- Voice and Speech Disorders
- Educational Systems and Policies
- Healthcare Education and Workforce Issues
- IL-33, ST2, and ILC Pathways
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Health and Wellbeing Research
- Psychosocial Factors Impacting Youth
- Immune cells in cancer
- Organ Transplantation Techniques and Outcomes
- Diabetes Treatment and Management
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Educational Research and Pedagogy
- Cardiac Fibrosis and Remodeling
- Systemic Lupus Erythematosus Research
- Eosinophilic Esophagitis
- Pancreatic function and diabetes
- Eicosanoids and Hypertension Pharmacology
Seoul National University
2016-2025
Seoul National University Hospital
2016-2025
Anyang University
2025
Hanyang University
2025
Samsung Medical Center
2021-2024
Sungkyunkwan University
2021-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2021-2024
Columbia University
2024
Keimyung University
2023
Keimyung University Dongsan Medical Center
2023
BackgroundEffective targeted therapy for non-small-cell lung cancer (NSCLC) patients with human epidermal growth factor receptor 2 (HER2) mutations remains an unmet need. This study investigated the antitumor effect of irreversible pan-HER tyrosine kinase inhibitor, pyrotinib.Patients and methodsUsing patient-derived organoids xenografts established from HER2-A775_G776YVMA-inserted advanced adenocarcinoma patient sample, we activity pyrotinib. Preliminary safety efficacy pyrotinib in 15...
The data were presented in abstract form at the 45th meeting of American Society Nephrology, October 30-November 04 2012, San Diego, CA, USA. Circulating autoantibodies against M-type phospholipase A2 receptor (PLA2R) are important pathogenic antibodies idiopathic membranous nephropathy (MN) adults. However, previous studies on clinical impact anti-PLA2R demonstrated several limitations, including insufficient numbers study subjects and different time points methods for antibody measurement....
The roles of neutrophils in renal inflammation are currently unclear. On examining these cells the unilateral ureteral obstruction murine model chronic kidney disease, we found that injured bore a large and rapidly expanding population expressed eosinophil marker Siglec-F. We first verified were neutrophils. Siglec-F+ recently detected several studies other disease contexts. then showed a) derived from conventional vasculature by TGF-β1 GM-CSF; b) they differed their parent more frequent...
Intestinal microbiota and their metabolites affect systemic inflammation kidney disease outcomes. Here, we investigated the key associated with acute injury (AKI)-to chronic (CKD) transition effect of antibiotic-induced depletion (AIMD) on this transition. In 61 patients AKI, 59 plasma were assessed to determine risk AKI-to-CKD An murine model was established four weeks after unilateral ischemia-reperfusion (IRI) effects AIMD gut microbiome, metabolites, pathological responses related CKD...
Graphene quantum dots (GQDs) have received much attention for their biomedical applications, such as bioimaging and drug delivery. Additionally, they antioxidant anti-inflammatory properties. We used GQDs to treat renal fibrosis confirmed ability protect cells from excessive oxidative stress in vitro vivo. Tubulointerstitial was induced by unilateral ureteral obstruction (UUO) 7- 8-week-old male C57BL/6 mice. were administered intravenous injection mimic clinical treatment. The levels of...
There is a significant immune response to ischemia-reperfusion injury (IRI), but the role of immunomodulatory natural killer T (NKT) cell subtypes not well understood. Here, we compared severity IRI in mice deficient type I/II NKT cells (CD1d−/−) or I (Jα18−/−). The absence cells, especially II accentuated renal injury, whereas repletion attenuated injury. Adoptively transferred trafficked into tubulointerstitium, which primary area Sulfatide-induced activation protected kidneys from IRI,...
We evaluated the impact of serum uric acid (SUA) on mortality in patients with chronic dialysis. A total 4132 adult dialysis were enrolled prospectively between August 2008 and September 2014. Among them, we included 1738 who maintained for at least 3 months had available SUA database. categorized time averaged-SUA (TA-SUA) into 5 groups: <5.5, 5.5-6.4, 6.5-7.4, 7.5-8.4, ≥8.5 mg/dL. Cox regression analysis was used to calculate hazard ratio (HR) all-cause according group. The mean TA-SUA...
Chronic kidney disease (CKD)-associated uremia aggravates-and is aggravated by-gut dysbiosis. However, the correlation between CKD severity and gut microbiota and/or their uremic metabolites unclear. We enrolled 103 patients with stage 1 to 5 46 healthy controls. analyzed patients' by MiSeq system measured serum concentrations of four (p-cresyl sulfate, indoxyl p-cresyl glucuronide, trimethylamine N-oxide) liquid chromatography-tandem mass spectrometry. Serum increased function...
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by autoreactive B cells and dysregulation of many other types immune including myeloid cells. Lupus nephritis (LN) a common target organ manifestations SLE. Tonicity-responsive enhancer-binding protein (TonEBP, also known as nuclear factor activated T-cells 5 (NFAT5)), was initially identified central regulator cellular responses to hypertonic stress pleiotropic involved in variety immunometabolic diseases. To explore...
TNF superfamily member 13 (TNFSF13) has been identified as a susceptibility gene for IgA nephropathy in recent genetic studies. However, the role of TNFSF13 progression remains unresolved. We evaluated two polymorphisms (rs11552708 and rs3803800) plasma levels 637 patients with nephropathy, determined risk ESRD according to theses variable. Neither examined associated clinical outcome nephropathy. high increased ESRD. To explore causal relationship underlying mechanism, we treated B cells...
<b><i>Background:</i></b> Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful in diagnosing idiopathic membranous nephropathy (IMN). We investigated the clinical relevance of PLA2R-Ab enzyme-linked immunosorbent assay (ELISA) patients with IMN. <b><i>Methods:</i></b> measured an ELISA kit from serum 160 IMN (n = 93), secondary MN 14) and other glomerulonephritis 41) as well healthy controls 12) at time renal biopsy correlation titers...
Periostin plays a crucial role in fibrosis, and acute kidney injury results high risk of progression to chronic disease. Therefore, we hypothesized that periostin was involved the fibrosis. Unilateral ischemia-reperfusion (UIRI) induced 7- 8-wk-old male wild-type periostin-null mice, animals were observed for 6 wk. In vitro, human kidney-2 cells primary-cultured tubular epithelial incubated under hypoxic conditions (5% O2, 5% CO2, 90% N2) 5 days. The also cultured with recombinant...
State-of-the-art automatic speech recognition (ASR) systems perform well on healthy speech.However, the performance impaired still remains an issue.The current study explores usefulness of using Wav2Vec self-supervised representations as features for training ASR system dysarthric speech.Dysarthric is particularly difficult several aspects such articulation, prosody and phonation can be impaired.Specifically, we train acoustic model with extracted from Wav2Vec, Hubert, cross-lingual XLSR...
We found that IRI increased expression of STAT3 in murine kidneys, along with inflammation markers. Through the investigation role AKI-to-CKD transition mechanism using mouse unilateral and ureteral obstruction models 24- or 72-h hypoxic induction primary cultured human tubular epithelial cells, we could affect transition. also observed different degrees isoforms these processes.
Endothelial cell damage and impaired angiogenesis substantially contribute to the progression of chronic renal failure (CRF). The effect endothelial progenitor (EPC) treatment on CRF is yet be determined. We performed 5/6 nephrectomy induce in C57BL/6 mice. EPCs were isolated from bone marrow, grown conditioned medium, characterized with surface marker analysis. serial changes kidney function histological features scrutinized mice EPC-treated (EPC-CRF) Adoptively transferred present at...
Although monitoring the intracellular concentration of immunosuppressive agents may be a promising approach to individualizing therapy after organ transplantation, additional studies on this issue are needed prior its clinical approval. We investigated relationship between and whole blood concentrations tacrolimus (IC-TAC WB-TAC, respectively), factors affecting relationship, risk rejection based upon IC-TAC in stable kidney recipients. Both WB-TAC were measured simultaneously 213 recipients...
Background Abnormal serum potassium concentration has been suggested as a risk factor for mortality in patients undergoing dialysis patients. We investigated the impact of levels on survival according to modality. Methods A nationwide, prospective, observational cohort study end stage renal disease ongoing Korea since August 2008. Our analysis included whose records contained data regarding levels. The relationship between and was analyzed using competing regression. Results total 3,230...
Cardiovascular disease (CVD) is the main public health problem in patients with chronic kidney (CKD); however, there no established biomarker for predicting CVD morbidity and mortality CKD. The aim of this study was to evaluate role circulating tumor necrosis factor receptors (cTNFRs) risk CKD patients. We prospectively recruited 984 from 11 centers between 2006 2012. levels cTNFR1 cTNFR2 were determined by performing an enzyme-linked immunosorbent assay. During mean follow-up period 4...
Interleukin-6 (IL6) is an important regulator of cellular hypertrophy through the gp130/Janus kinase 2 (JAK2)/signal transducer and activator transcription 3 (STAT3) pathway. We tested hypothesis that IL6 its downstream gp130/JAK2/STAT3 pathway participated in high glucose (HG)-induced podocyte hypertrophy.IL6 levels media lysates podocytes were measured by enzyme-linked immunosorbent assay. Western blots performed to determine protein expression among cultured with normal (NG), NG +...
Driver monitoring systems play an important role in lower to mid-level autonomous vehicles. Our work focuses on the detection of cognitive load as a component driver-state estimation improve traffic safety. By inducing single and dual-task workloads increasing intensity 51 subjects, while continuously measuring signals from multiple modalities, based physiological measurements such ECG, EDA, EMG, PPG, respiration rate, skin temperature eye tracker data, well behavioral action units extracted...
As a leading cause of chronic kidney disease, clinical demand for noninvasive biomarkers diabetic disease (DKD) beyond proteinuria is increasing. Metabolomics popular method to identify mechanisms and biomarkers. We investigated urinary targeted metabolomics in DKD patients.We conducted study 26 metabolites consecutive patients with stage 1 5 (n = 208) healthy controls 26). The relationships between estimated glomerular filtration rate (eGFR) or urine protein-creatinine ratio (UPCR) were...