A5048637818- Dialysis and Renal Disease Management
- Spectroscopy and Chemometric Analyses
- Ginseng Biological Effects and Applications
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects of Natural Compounds
- Listeria monocytogenes in Food Safety
- Fungal Biology and Applications
- Disability Education and Employment
- Platelet Disorders and Treatments
- Identification and Quantification in Food
- Pesticide Residue Analysis and Safety
- Gut microbiota and health
- Biosensors and Analytical Detection
- Medicinal plant effects and applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Mycotoxins in Agriculture and Food
- Advanced Chemical Sensor Technologies
- Renal Diseases and Glomerulopathies
- Collaborative Teaching and Inclusion
- Pharmacology and Obesity Treatment
- Pharmacological Effects and Toxicity Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protein Hydrolysis and Bioactive Peptides
- Spectroscopy Techniques in Biomedical and Chemical Research
- Insect and Pesticide Research
Chungbuk National University Hospital
2018-2024
Sungkyunkwan University
2024
Konyang University
2009-2022
Chonnam National University
2021
Chungbuk National University
2020
Ewha Womans University
2019
National Institute of Food and Drug Safety Evaluation
2019
Institute of Biomedical Science
2018
Agricultural Research Service
2016-2017
United States Department of Agriculture
2017
Abstract Most individuals with Down Syndrome (DS) show an early‐onset of Alzheimer’s disease (AD), which potentially results from the presence extra copy a segment chromosome 21. Located on 21 are genes that encode β‐amyloid (Aβ) precursor protein ( APP ), key involved in pathogenesis AD, and dual‐specificity tyrosine(Y)‐phosphorylation regulated kinase 1A DYRK1A proline‐directed plays critical role neurodevelopment. Here, we describe potential mechanism for regulation AD pathology DS brains...
Researchers have suggested models to predict the risk of postoperative AKI (PO-AKI), but an externally validated index that can be practically implemented before patients undergo noncardiac surgery is needed.We performed a retrospective observational study without preexisting renal failure who underwent operation (≥1 hour) at two tertiary hospitals in Korea. We fitted proportional odds model for ordinal outcome consisting three categories: critical (defined as Kidney Disease Improving Global...
Relatively little is known about thrombotic adverse events (AEs) of emicizumab in postmarketing real-world settings, particularly comparison with factor VIII (FVIII) products. A recent European study reported a potentially greater risk compared FVIII
We evaluated the impact of serum uric acid (SUA) on mortality in patients with chronic dialysis. A total 4132 adult dialysis were enrolled prospectively between August 2008 and September 2014. Among them, we included 1738 who maintained for at least 3 months had available SUA database. categorized time averaged-SUA (TA-SUA) into 5 groups: <5.5, 5.5-6.4, 6.5-7.4, 7.5-8.4, ≥8.5 mg/dL. Cox regression analysis was used to calculate hazard ratio (HR) all-cause according group. The mean TA-SUA...
As adulteration of foodstuffs with Sudan dye, especially paprika- and chilli-containing products, has been reported some frequency, this issue become one focal point for addressing food safety. FTIR spectroscopy used extensively as an analytical method quality control safety determination products. Thus, the use rapid dye in paprika powder was investigated study. A net analyte signal (NAS)-based methodology, named HLA/GO (hybrid linear analysis literature), applied to spectral data predict...
Data regarding kidney transplantation (KT) and dialysis outcomes are rare in Asian populations. In the present study, we evaluated clinical associated with KT using claims data from Korean national public health insurance program. Among 35,418 adult patients incident treated between 2005 2008 Korea, 1539 underwent KT. An optimal balanced risk set matching was attempted to compare transplant group control terms of overall survival major adverse cardiac event–free survival. Before matching,...
Chronic kidney disease (CKD)-associated uremia aggravates-and is aggravated by-gut dysbiosis. However, the correlation between CKD severity and gut microbiota and/or their uremic metabolites unclear. We enrolled 103 patients with stage 1 to 5 46 healthy controls. analyzed patients' by MiSeq system measured serum concentrations of four (p-cresyl sulfate, indoxyl p-cresyl glucuronide, trimethylamine N-oxide) liquid chromatography-tandem mass spectrometry. Serum increased function...
Neutrophils are the first-line defense against microbes. Enhancing microbicidal activity of neutrophils could complement direct antimicrobial therapy for controlling intractable microbial infections. Previously, we reported that lysophosphatidylcholine (LPC), an endogenous lipid, enhances neutrophil bactericidal (Yan et al. 2004. Nat. Med. 10: 161-167). In this study show LPC enhancement is dependent on glycine, and mediated by translocation intracellularly located glycine receptor (GlyR)...
The effects of onion peel extract (OPE) in collagen (5 μg/mL)-stimulated washed rat platelet aggregation were investigated. OPE inhibited via inhibition aggregation-inducing molecules, intracellular Ca(2+) and thromboxane A2 (TXA2) by blocking cyclooxygenase-1 (COX-1) TXA2 synthase (TXAS) activities a dose-dependent manner. In addition, elevated the formation cyclic adenosine monophosphate (cAMP), aggregation-inhibiting molecule, but not guanosine (cGMP). High performance liquid...
This study aims to compare the classification performance of statistical models on highly imbalanced kidney data. The health examination cohort database provided by National Health Insurance Service in Korea is utilized build with various machine learning methods. glomerular filtration rate (GFR) used diagnose chronic disease (CKD). It calculated using Modification Diet Renal Disease method and classified into five stages (1, 2, 3A 3B, 4, 5). Different CKD based estimated GFR are considered...
Aim: In this study, we investigated the effect of (−)-epigallocatechin-3-gallate (EGCG) on cyclic nucleotide production and vasodilator-stimulated phosphoprotein (VASP) phosphorylation in collagen (10 µg/mL)-stimulated platelet aggregation.Methods: Washed platelets (108/mL) from Sprague-Dawley rats (6-7 weeks old, male) were preincubated for 3 min at 37°C presence 2 mM exogenous CaCl2 with or without EGCG other materials, stimulated µg/mL) 5 min, then used determination intracellular...
The No Child Left Behind Act (2001) and the Individuals with Disabilities Education Improvement (2004) emphasize accountability to improve student academic achievement. Promoting self-determination has been proposed as a means achieving this outcome. Elementary teachers in 30 states were surveyed measure (a) their perceived importance of self-determination, (b) what extent they teach it, (c) barriers that inhibit them from teaching it. Both general special educators assigned considerable...
In this study, we investigated the effects of caffeic acid (CAFA), a phenolic acid, on Ca(2＋)-antagonistic cyclic nucleotides associated with phosphorylation inositol 1,4,5-trisphosphate receptor (IP3R) and vasodilator-stimulated phosphoprotein (VASP) thromboxane A2 (TXA2)-associated microsomal cyclooxygenase-1 (COX-1) activity in collagen (10 μg/mL)-stimulated platelet aggregation.Washed platelets (10(8)/mL) obtained from Sprague-Dawley rats (6-7 weeks old, male) were preincubated for 3...
Excessive dietary salt intake is related to cardiovascular morbidity and mortality. Although restriction essential, it difficult achieve because of palatability. However, the association between perception or eating habit actual remains uncertain. In this study, we recruited 74 healthy young individuals. We investigated their salt-eating habits by questionnaire taste threshold through a rating scale that used serial dilution sodium chloride solution. Predicted 24-hr urinary excretions using...
Glycoprotein IIb/IIIa (αIIb/β
Diabetic mellitus nephropathy (DMN) is a serious complication of diabetes and major health concern. Although the pathophysiology (DM) leading to DMN uncertain, recent evidence suggests involvement gut microbiome. This study aimed determine relationships among microbial species, genes, metabolites in through an integrated clinical, taxonomic, genomic, metabolomic analysis. Whole-metagenome shotgun sequencing nuclear magnetic resonance analyses were performed on stool samples from 15 patients...
In this study, we investigated the effect of chlorogenic acid, a phenolic on collagen (10 μg/ml)-stimulated platelet aggregation. Chlorogenic acid dose-dependently inhibited collagen-induced aggregation, and suppressed production thromboxane A2 (TXA2), an intracellular Ca-agonist as aggregation-inducing autacoidal molecule, which was associated with strong inhibition cyclooxygenase (COX)-1 in microsomes having cytochrome c reductase activity. addition, increased significantly formation...